BRAF V600E Mutation Identifies a Subset of Low-Grade Diffusely Infiltrating Gliomas in Adults

Mutant BRAF in low‐grade epilepsy‐associated tumors and focal cortical dysplasia

“…This finding, only rarely documented in large systematic studies,10,20 is consistent with a recent report21 in which the BRAF V600E mutation was identified in five (15%) out of 33 consecutive grade 2 diffuse gliomas. The authors observed that four out of these five BRAF -mutant grade 2 diffuse gliomas presented with long-standing, frequent, sometimes refractory seizures and all four tumors were located within the temporal lobe.…”

Analysis of IDH1-R132 mutation, BRAF V600 mutation and KIAA1549–BRAF fusion transcript status in central nervous system tumors supports pediatric tumor classification

“…Interestingly, PAs in our cohort showed the opposite pattern with only one V600E mutation (2 %) in the pediatric group but up to 7-25 % positive cases in the 19-35-year group (Table 2). Notably, there is growing evidence that V600E mutations might be also present in young adults diagnosed with DA (Chi et al 2013). These patients show a clinical course that is more similar to PA of the same age group.…”

BRAF V600E mutation in neocortical posterior temporal epileptogenic gangliogliomas

“…Therefore, molecular or immunohistochemical detection of BRAF V600E mutation may be a valuable tool in the diagnosis of glioneuronal lesions [26]. In fact, this alteration is frequently present in LEAT, while it is observed only in low percentages of diffuse gliomas [26,27].…”