2022
DOI: 10.1080/2162402x.2021.2016158
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CEBPA mutants down-regulate AML cell susceptibility to NK-mediated lysis by disruption of the expression of NKG2D ligands, which can be restored by LSD1 inhibition

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Cited by 9 publications
(14 citation statements)
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“…Liu et al revealed that CEBPA, one of the most studied lineage-specific transcription factors in haematopoiesis, might influence the expression of NKG2D; thus, the high endogenous CEBPA-expressing decreased the sensitivity to NK cell cytotoxicity. 24 NKG2D is one of the most critical activating receptors expressed by NK cells and CD8+ αβ+ T cells and binds to MHC Class I chain-related genes (MIC). The binding of NKG2D to MIC protein on the target tumour cells releases the cytotoxicity effect of NK cells.…”
Section: Discussionmentioning
confidence: 99%
“…Liu et al revealed that CEBPA, one of the most studied lineage-specific transcription factors in haematopoiesis, might influence the expression of NKG2D; thus, the high endogenous CEBPA-expressing decreased the sensitivity to NK cell cytotoxicity. 24 NKG2D is one of the most critical activating receptors expressed by NK cells and CD8+ αβ+ T cells and binds to MHC Class I chain-related genes (MIC). The binding of NKG2D to MIC protein on the target tumour cells releases the cytotoxicity effect of NK cells.…”
Section: Discussionmentioning
confidence: 99%
“…AML therapy failure is mostly due to frequent relapses arising from the residual disease, and the immune system is considered crucial for elimination of leukemia cells surviving after chemotherapy and hematopoietic cell transplantation. Compared to solid tumors, AML has a low mutational burden, but several driver mutations with high incidence produce immunogenic peptides 38 and AML is susceptible to attack by both the innate and adaptive immune system. 6 However, multiple molecular mechanisms can mediate immune evasion or active immune suppression.…”
Section: Discussionmentioning
confidence: 99%
“…Human AML cell lines and 32Dcl3 murine myeloid cell line were transduced with recombinant lentiviruses and the plasmids used in this study have been previously described [ 23 ]. Detailed information is described in Supplemental Materials and Methods.…”
Section: Methodsmentioning
confidence: 99%
“…RNA analysis was extracted as previously described [ 23 ]. Specific procedures are described in Supplemental Materials and Methods.…”
Section: Methodsmentioning
confidence: 99%