<i>Coxiella</i>

Drancourt, Michel; Raoult, Didier

doi:10.1002/9781118960608.gbm01176

Cited by 3 publications

(3 citation statements)

References 77 publications

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“…Coxiella is a bacterial genus composed of intracellular Gram-negative rods [ 137 ]. To date, only Coxiella burnetii has been associated with human disease.…”

Section: Coxiella Burnetiimentioning

confidence: 99%

“…To date, only Coxiella burnetii has been associated with human disease. It has two antigenic phase variants: the phase I variant, which is the virulent form of the bacteria that can be found in nature and predominates in chronic forms of the disease, and the phase II variant, which is an attenuated form of the bacteria and is associated with acute forms of disease [ 137 , 138 ]. C. burnetii is an aerosol-borne pathogen; its natural form is highly resistant to chemical agents and extreme environmental conditions.…”

Section: Coxiella Burnetiimentioning

confidence: 99%

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Etiologies of Zoonotic Tropical Febrile Illnesses That Are Not Part of the Notifiable Diseases in Colombia

Silva-Ramos,

Faccini-Martínez,

Serna-Rivera

et al. 2023

Microorganisms

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In Colombia, tropical febrile illnesses represent one of the most important causes of clinical attention. Febrile illnesses in the tropics are mainly zoonotic and have a broad etiology. The Colombian surveillance system monitors some notifiable diseases. However, several etiologies are not monitored by this system. In the present review, we describe eleven different etiologies of zoonotic tropical febrile illnesses that are not monitored by the Colombian surveillance system but have scientific, historical, and contemporary data that confirm or suggest their presence in different regions of the country: Anaplasma, Arenavirus, Bartonella, relapsing fever group Borrelia, Coxiella burnetii, Ehrlichia, Hantavirus, Mayaro virus, Orientia, Oropouche virus, and Rickettsia. These could generate a risk for the local population, travelers, and immigrants, due to which they should be included in the mandatory notification system, considering their importance for Colombian public health.

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“…Coxiella is a bacterial genus composed of intracellular Gram-negative rods [ 137 ]. To date, only Coxiella burnetii has been associated with human disease.…”

Section: Coxiella Burnetiimentioning

confidence: 99%

Section: Coxiella Burnetiimentioning

confidence: 99%

Etiologies of Zoonotic Tropical Febrile Illnesses That Are Not Part of the Notifiable Diseases in Colombia

Silva-Ramos,

Faccini-Martínez,

Serna-Rivera

et al. 2023

Microorganisms

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“…The causative agent of Q fever is the intracellular obligate Gram-negative bacterium Coxiella burnetii (Drancourt and Raoult 2005;Kilic and Celebi 2008;Angelakis and Raoult 2010). Q fever is one of the most common zoonotic diseases in the world (Maurin and Raoult 1999).…”

mentioning

confidence: 99%

Coxiella burnetii in samples from cattle herds and sheep flocks in the Kars region of Turkey

Sağlam¹,

Şahin²

2016

Vet. Med.

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This study was aimed at determining the presence of C. burnetii in cattle and sheep herds in the Kars region of Turkey using serological and molecular methods. As a serological technique, C.burnetii IgG in blood sera and milk samples were investigated with ELISA. The results of these examinations revealed that 108 (43.2%) out of 250 sheep blood serum samples and 52 (14.85%) out of 350 cattle blood serum samples were seropositive for C. burnetii antibodies by ELISA. Out of 350 cattle and 250 sheep milk samples examined with ELISA, 36 (10.28%) and 42 (16.8%) were found to be seropositive, respectively. For molecular analysis, a Trans-PCR amplifying the IS1111A transposase gene of C. burnetii was conducted. Five (1.42%) out of 350 cattle milk samples, and one (0.4%) from 250 sheep milk samples were found to be positive for C. burnetii DNA. The results obtained in this study have demonstrated the presence of Q fever in cattle and sheep in the Kars region, and the dissemination of the infectious agent within milk. This situation poses a potential risk for animal and human health. Ultimately, this study points the way to future investigations into the presence of C. burnetii, which causes Q fever in cattle and sheep, and will contribute to the protection and control of the disease.

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Current knowledge of the taxonomy and classification of representatives from the order Legionellales (Legionellaceae, Coxiellaceae) Phylum Pseudomonadota

2024

CMAC

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Since the development of microbiology as a science, the identification, systematics and classification of microorganisms have been carried out based on the study of phenotypic characteristics. In the second half of the 20th century, after the discovery of the structure of DNA and polymerase chain reaction, the era of molecular biological research began in microbiology. Since 2002, the use of a complex of molecular biological and phylogenetic methods has been recommended as a guiding approach in the classification and taxonomy of prokaryotes, which has led to reclassification in some taxa. The representation of the taxonomy of Legionella pneumophila (order Legionellales, class Gammaproteobacteria) was formulated after the outbreak of legionnaires’ disease (legionellosis) in the USA in 1976. The description of the causative agent of Q-fever – Coxiella burnetii occurred 40 years earlier, but its classification and taxonomic status in the order Rickettsiales of the class Alphaproteobacteria were presented incorrectly based on the study of available phenotypic characteristics in the 1930s and 1950s. This determined the «fate» of C. burnetii and Q-fever for half a century, included in the list of rickettsiae and rickettsioses traditionally studied by rickettsiologists. As a result of the application of molecular biological methods in the 1990s, in the order Legionellales was replenished by several representatives of the order Rickettsiales, three representatives of which (C. burnetii, Rickettsiella grilli and Wolbachia persica) were moved to the class Gammaproteobacteria. Analysis of the 16S rRNA gene sequence led to the reclassification of Coxiella into a separate genus of gamma-proteobacteria of the phylum Proteobacteria (now Pseudomonadota) along with the genera Legionella, Francisella and Rickettsiella with representatives of which have the greatest phylogenetic relationship. Sequencing of the 16S rRNA gene of C. burnetii isolates from different geographical regions revealed only three nucleotide substitutions, indicating that the nucleotide sequences of these strains are closely related (the degree of homology is 99%), which confirms the phylogenetic uniformity of the genus Coxiella within a single species. A comparative analysis of the proteome of representatives of the order Legionellales and a phylodendrogramm constructed during the study of the main proteins of representatives of the genera Legionella, Coxiella, Acquicella and Rickettsiella (Diplorickettsia) allowed the formation of various clades confirming their monophyla. The C. burnetii genome encodes 24 similar components out of 27 involved in the pathogenesis of L. pneumophila by type IVB secretory system (type IVB secretory systems). Verification of the taxonomic position of C. burnetii is an example of the use of molecular biological methods to solve problems of taxonomy and classification of prokaryotes. It is advisable to use an integrated approach based on the application of «classical» methods of bacteriology and new molecular biological and phylogenetic methods, which will allow to obtain an objective understanding of the microorganisms associated with the human population.

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Coxiella

Cited by 3 publications

References 77 publications

Etiologies of Zoonotic Tropical Febrile Illnesses That Are Not Part of the Notifiable Diseases in Colombia

Etiologies of Zoonotic Tropical Febrile Illnesses That Are Not Part of the Notifiable Diseases in Colombia

Coxiella burnetii in samples from cattle herds and sheep flocks in the Kars region of Turkey

Current knowledge of the taxonomy and classification of representatives from the order Legionellales (Legionellaceae, Coxiellaceae) Phylum Pseudomonadota

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