<i>Daphne oleoides</i>: An alternative source of important sesquiterpenes

Uysal, Ahmet; Zengin, Gökhan; Rigano, Daniela; Senatore, Felice; Şanda, Murad Aydın

doi:10.1080/10942912.2016.1168836

Cited by 8 publications

(5 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Caryophyllene oxide, dibutyl phthalate, and eicosane are reportedly known as the main compounds in D. mucronata [13] . Also, compounds such as hexadecanoic acid, caryophyllene oxide, and phytol were reported in other species of the Daphne genus [30,31] . Caryophyllene oxide is highly regarded for its antioxidant and anticancer properties [32] .…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Phytochemicals, Essential Oils Composition and Antioxidant Activity of Astragalus spp., Phlomis olivieri and Daphne mucronata in Habitats of Central Iran

Ghorbani,

Golkar,

Jafari

et al. 2023

Chemistry & Biodiversity

View full text Add to dashboard Cite

This study evaluated secondary metabolites, essential oil compositions, and antioxidant activity in four medicinal plants that originated in Isfahan rangelands. The species were Astragalus verus, Astragalus adscendens, Daphne mucronata, and Phlomis olivieri. Thirty‐two genotypes of these species were evaluated for different biochemical traits. Based on the evaluation of EO compounds, GC‐MS analysis revealed the total number of identified compounds. These compounds were 25, 22, 12, and 22 for A. adscendens, A. verus, D. mucronata, and P. olivieri, respectively. The dominant compounds were phthalate (59.88%) in A. adscendens, phytol (38.02%) in A. verus, hexanoic acid (32.05%) in D. mucronata and β‐cubebene (30.94%) in P. olivieri. Phytochemical analysis showed that D. mucronata, A. adscendens, and P. olivieri had the highest total phenolic content (TPC) (18.24 mg gallic acid equivalent/g dry weight), total flavonoids (5.57 mg QE/g DW), and total anthocyanin content (0.23 mg/g DW), respectively. The highest total chlorophyll (0.27 mg/g DW), total carotenoids (0.03 mg/g DW), and antioxidant activity (71.36 %) were observed in A. adscendens, A. adscendens and A. verus, respectively. The data revealed that superior genotypes from these species are rich in natural antioxidants and bioactive compounds. Thus, they can be used in ethno pharmacological fields and industrial applications.

show abstract

Section: Resultsmentioning

confidence: 99%

“…[13] Also, compounds such as hexadecanoic acid, caryophyllene oxide, and phytol were reported in other species of the Daphne genus. [30,31] Caryophyllene oxide is highly regarded for its antioxidant and anticancer properties. [32] Caryophyllene oxide existed in D. mucronata and P. olivieri.…”

Section: Essential Oils Analysismentioning

confidence: 99%

Phytochemicals, Essential Oils Composition and Antioxidant Activity of Astragalus spp., Phlomis olivieri and Daphne mucronata in Habitats of Central Iran

Ghorbani,

Golkar,

Jafari

et al. 2023

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…6 Subsequent studies report that nootkatone is isolated from peel oil of citrus plants such as grapefruit, oranges, and lemons 25 and also found in plants of Vetiveria zizanioides, 26 C. rotundus, 27 Hesperotropsis leylandii, 28 Juniperus chinensis, 29 Daphne oleoides subsp. oleoides, 30 and Anisomeles indica Kuntze. 31 Currently, the commercial production of nootkatone mainly relies on the extraction from grapefruit peels.…”

Section: Production Of Valencene and Nootkatonementioning

confidence: 99%

“…oleoides essential oil (active component being nootkatone) was an effective antibacterial agent against Bacillus sp., Staphylococcus sp., Proteus sp., Streptococcus aecalis, E. coli, and P. aeruginosa. 30 Furthermore, nootkatone can be used as a starting compound to synthesize novel fused-thiazolo derivatives that were extremely effective antibacterial agents against S. aureus and E. faecium. 93 On the other hand, nootkantone also presented good antifungal activity.…”

Section: Biological Propertiesmentioning

confidence: 99%

Production, Function, and Applications of the Sesquiterpenes Valencene and Nootkatone: a Comprehensive Review

Zhang

Chen

et al. 2022

J. Agric. Food Chem.

View full text Add to dashboard Cite

Valencene and nootkatone, two sesquiterpenes, extracted from natural sources, have great market potential with diverse applications. This paper aims to comprehensively review the recent advances in valencene and nootkatone, including source, production, physicochemical and biological properties, safety and pharmacokinetics evaluation, potential uses, and their industrial applications as well as future research directions. Microbial biosynthesis offers a promising alternative approach for sustainable production of valencene and nootkatone. Both compounds exert various beneficial activities, including antimicrobial, insecticidal, antioxidant, anti-inflammatory, anticancer, cardioprotective, neuroprotective, hepatoprotective, and nephroprotective and other activities. However, most of the studies are performed in animals and in vitro, making it difficult to give a conclusive description about their health benefits and extend their application. Hence, more attention should be paid to in vivo and long-term clinical studies in the future. Moreover, valencene and nootkatone are considered safe for consumption and show great promise in the applications of food, cosmetic, pharmaceutical, chemical, and agricultural industries.

show abstract

“…The bark contains diterpenes including mezerein and daphnetoxin (0.02%) [18] , [19] of which mezerein is anti-inflammatory and anti-carcinogenic [ 19 ]. Previous research studies have reported wound-healing [ 20 ], antimicrobial [ 21 ] and antioxidant properties [ 20 ] of D. oleoides Schreb., but till date no scientific study has been carried out on its crude and detoxified forms to document the comparative pharmacological effect of Mazaryun before and after detoxification. Therefore, the present study was envisaged to evaluate the anti-inflammatory activity of the crude and detoxified leaves of D. oleoides on carrageenan-induced paw edema in Wistar rats.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory activity of crude and detoxified leaves of Daphne oleoides Schreb. on carrageenan-induced paw edema in wistar rats

Rahman

Jahan²

2021

Journal of Ayurveda and Integrative Medicine

View full text Add to dashboard Cite

Background Mazaryun ( Daphne oleoides Schreb.) is used as an anti-inflammatory drug in Unani medicine after detoxification, as it is defined under fourth-degree drugs. Objective(s) To evaluate and compare the anti-inflammatory activity of crude and detoxified Mazaryun in maximum and minimum doses . Materials and methods Anti-inflammatory activity was carried out by carrageenan-induced paw edema test. Wistar rats of either sex, weighing 150–200 gm, were divided into seven groups (I, II, IIIA, IIIB, IVA, IVB, and V) of six animals in each. Group I - plain control, administered with 1 ml of 1% CarboxyMethyl Cellulose (CMC); Group II - standard control, given Diclofenac Sodium (6 mg/kg); Group III - crude Mazaryun and Group IV - detoxified Mazaryun, A and B are maximum and minimum doses of test drug, respectively; and V group - positive control was not treated with any other drugs. The data was statistically analyzed by ANOVA repeated for inter-group analysis and ANOVA one-way for intra-group analysis with post hoc Tukey Kramer multiple comparison test. The GC–MS analysis of crude and detoxified leaves of Mazaryun was also carried out in continuation of study to determine the phytochemical changes before and after detoxification. Results Maximum dose of detoxified Mazaryun and standard control groups showed significant anti–inflammatory activity at p < 0.001, and detoxified Mazaryun showed dose-dependent activity. The GC–MS fingerprints showed totally eight different chemical constituents in its crude and detoxified form . Conclusion The study standardised the concept of detoxication in Unani medicine, as the detoxified Mazaryun showed significant anti-inflammatory activity and present of totally different chemicals constituents.

show abstract

Daphne oleoides: An alternative source of important sesquiterpenes

Cited by 8 publications

References 44 publications

Phytochemicals, Essential Oils Composition and Antioxidant Activity of Astragalus spp., Phlomis olivieri and Daphne mucronata in Habitats of Central Iran

Phytochemicals, Essential Oils Composition and Antioxidant Activity of Astragalus spp., Phlomis olivieri and Daphne mucronata in Habitats of Central Iran

Production, Function, and Applications of the Sesquiterpenes Valencene and Nootkatone: a Comprehensive Review

Anti-inflammatory activity of crude and detoxified leaves of Daphne oleoides Schreb. on carrageenan-induced paw edema in wistar rats

Contact Info

Product

Resources

About