<i>Dendrobium nobile</i> Lindl alkaloid, a novel autophagy inducer, protects against axonal degeneration induced by Aβ<sub>25‐35</sub> in hippocampus neurons in vitro

Liu, Lisheng; Lu, Yanliu; Nie, Jing; Xu, Yun-Yan; Zhang, Wei; Yang, Wenjin; Gong, Qihai; Lu, Yuan‐Fu; Yang, Lu; Shi, Jingshan

doi:10.1111/cns.12678

Cited by 82 publications

(49 citation statements)

References 38 publications

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“…In this regard, ginsenoside-Rg2 could induce mTOR-independent autophagy, enhancing the removal of cerebral Aβ in a 5 × FAD mouse model of AD (Fan et al, 2017). Plant-derived alkaloids are also a desirable choice to increase autophagic flux and Aβ degradation in hippocampus neurons (Li et al, 2017). Additionally, there are some other compounds such as polyphenols (curcumin, resveratrol, and emodin, .…”

Section: Therapeutic Approachesmentioning

confidence: 99%

Interplay Between Mitochondrial Oxidative Disorders and Proteostasis in Alzheimer’s Disease

et al. 2020

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Although the basis of Alzheimer's disease (AD) etiology remains unknown, oxidative stress (OS) has been recognized as a prodromal factor associated to its progression. OS refers to an imbalance between oxidant and antioxidant systems, which usually consist in an overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS) which overwhelms the intrinsic antioxidant defenses. Due to this increased production of ROS and RNS, several biological functions such as glucose metabolism or synaptic activity are impaired. In AD, growing evidence links the ROS-mediated damages with molecular targets including mitochondrial dynamics and function, protein quality control system, and autophagic pathways, affecting the proteostasis balance. In this scenario, OS should be considered as not only a major feature in the pathophysiology of AD but also a potential target to combat the progression of the disease. In this review, we will discuss the role of OS in mitochondrial dysfunction, protein quality control systems, and autophagy associated to AD and suggest innovative therapeutic strategies based on a better understanding of the role of OS and proteostasis.

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Section: Therapeutic Approachesmentioning

confidence: 99%

Interplay Between Mitochondrial Oxidative Disorders and Proteostasis in Alzheimer’s Disease

et al. 2020

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“…Dendrobium nobile , an alkaloid derivative from Orchidacee very common in China, has been recently demonstrated to protect hippocampal neurons exposed to β-amyloid by promoting Beclin 1 and accelerating autophagic flux ( Li et al, 2017 ).…”

Section: Nutraceuticals Effective In Neurodegeneration Via Autophagymentioning

confidence: 99%

Natural Compounds and Autophagy: Allies Against Neurodegeneration

Stacchiotti

Corsetti

2020

Front. Cell Dev. Biol.

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Prolonging the healthy life span and limiting neurological illness are imperative goals in gerontology. Age-related neurodegeneration is progressive and leads to severe diseases affecting motility, memory, cognitive function, and social life. To date, no effective treatments are available for neurodegeneration and irreversible neuronal loss. Bioactive phytochemicals could represent a natural alternative to ensure active aging and slow onset of neurodegenerative diseases in elderly patients. Autophagy or macroautophagy is an evolutionarily conserved clearing process that is needed to remove aggregateprone proteins and organelles in neurons and glia. It also is crucial in synaptic plasticity. Aberrant autophagy has a key role in aging and neurodegeneration. Recent evidence indicates that polyphenols like resveratrol and curcumin, flavonoids, like quercetin, polyamine, like spermidine and sugars, like trehalose, limit brain damage in vitro and in vivo. Their common mechanism of action leads to restoration of efficient autophagy by dismantling misfolded proteins and dysfunctional mitochondria. This review focuses on the role of dietary phytochemicals as modulators of autophagy to fight Alzheimer's and Parkinson's diseases, fronto-temporal dementia, amyotrophic lateral sclerosis, and psychiatric disorders. Currently, most studies have involved in vitro or preclinical animal models, and the therapeutic use of phytochemicals in patients remains limited.

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“…Alkaloids are important examples of active compounds isolated from plants and show anticholinesterase and modulatory effects on autophagy implicated in the treatment of neurodegenerative diseases. For instance, alkaloids can modulate autophagy in AD [87], and Dendrobium nobile Lindl extracts possess alkaloids components that are capable of hindering axonal degeneration [88]. Plant alkaloid berberine ameliorated learning and memory functions, and accelerated Aβ clearance in an AD mouse model [89].…”

Section: Use Of Natural Compound To Modulate Autophagy In Admentioning

confidence: 99%

Promising Modulatory Effects of Autophagy on APP Processing as a Potential Treatment for Alzheimer's Disease

Rahman¹,

Rahman²,

Rahman³

et al. 2020

Preprint

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Autophagy refers to the degradation of cytoplasmic constituents by a lysosomal-mediated pathway, which plays a critical role in maintaining cellular homeostasis. Importantly, dysregulation of autophagy has been implicated in multiple neurodegenerative disorders. Previous studies reported that autophagy affects the processing of amyloid precursor protein (APP), thus stimulating β‐amyloid (Aβ) production in Alzheimer’s disease (AD) eventually. Although the mechanism of autophagy modulation on APP processing and its pathogenesis has not yet been fully elucidated at the molecular level, but modulation of autophagy has received considerable attention as a promising approach for the treatment of AD. In the early stage of AD, Aβ may prompt autophagy to facilitate its removal via mTOR‐independent as well as-dependent pathways. However, a recent study proposed that autophagy processes are not properly regulated as AD continues to progress, and consequently, the production of Aβ tends to accumulate rapidly. Meanwhile, a number of autophagy-related genes (Atg) as well as APP genes are also thought to influence the development of AD, which may serve as a bi‐directional link to autophagy and AD pathology. In this review, we summarized current observations related to autophagy regulation and APP processing, focusing on their dynamic modifications associated with the progression of AD. Recent findings together highlight the essential role of autophagy in the removal and clearance of APP and Aβ deposition in the pathological condition of AD.

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Dendrobium nobile Lindl alkaloid, a novel autophagy inducer, protects against axonal degeneration induced by Aβ_25‐35 in hippocampus neurons in vitro

Abstract: DNLA prevents Aβ -induced axonal degeneration via activation of autophagy process and could be a novel therapeutic target.

Cited by 82 publications

References 38 publications

Interplay Between Mitochondrial Oxidative Disorders and Proteostasis in Alzheimer’s Disease

Interplay Between Mitochondrial Oxidative Disorders and Proteostasis in Alzheimer’s Disease

Natural Compounds and Autophagy: Allies Against Neurodegeneration

Promising Modulatory Effects of Autophagy on APP Processing as a Potential Treatment for Alzheimer's Disease

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Dendrobium nobile Lindl alkaloid, a novel autophagy inducer, protects against axonal degeneration induced by Aβ25‐35 in hippocampus neurons in vitro

Abstract: DNLA prevents Aβ -induced axonal degeneration via activation of autophagy process and could be a novel therapeutic target.

Cited by 82 publications

References 38 publications

Interplay Between Mitochondrial Oxidative Disorders and Proteostasis in Alzheimer’s Disease

Interplay Between Mitochondrial Oxidative Disorders and Proteostasis in Alzheimer’s Disease

Natural Compounds and Autophagy: Allies Against Neurodegeneration

Promising Modulatory Effects of Autophagy on APP Processing as a Potential Treatment for Alzheimer's Disease

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Product

Resources

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Dendrobium nobile Lindl alkaloid, a novel autophagy inducer, protects against axonal degeneration induced by Aβ_25‐35 in hippocampus neurons in vitro