<i>Enterococcus faecalis</i> Endophthalmitis in Children – A 21 Year Study

Rishi, Ekta; Rishi, Pukhraj; Bhende, Pramod; Raman, Rajiv; Sen, Parveen; Susvar, Pradeep; Rao, C.H. Srinivasa; Therese, Lily; Nagesha, C K

doi:10.1080/09273948.2017.1385816

Cited by 5 publications

(7 citation statements)

References 29 publications

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“…From these 291 cases, 7 (2.4%) were Enterococcus species, including 4 (1.4%) E. faecalis [6]. Table 2 illustrates the comparison of published studies and this current study of endophthalmitis caused by E. faecalis [5,7,[9][10][11][12][13][14][15][16][17][18]. There was no change in the trend of antibiotic susceptibility for E. faecalis between our current study and our previous one.…”

Section: Discussionsupporting

confidence: 55%

“…E. faecalis, a relatively rare cause of endophthalmitis, is identified as a pathogen in both exogenous and endogenous etiologies. Exogenous E. faecalis endophthalmitis is primarily caused by trauma and post-surgery, such as cataract extraction, trabeculectomy, penetrating keratoplasty, vitrectomy, and intravitreal injection [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. E. faecalis accounted for approximately 1% of culture-positive acute post-cataract surgery endophthalmitis cases in the Endophthalmitis Vitrectomy Study [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…E. faecalis accounted for approximately 1% of culture-positive acute post-cataract surgery endophthalmitis cases in the Endophthalmitis Vitrectomy Study [5,6]. E. faecalis is known to cause severe acute endophthalmitis and often leads to poor visual outcomes in most ophthalmic infections [7][8][9][10][11][12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

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Enterococcus faecalis Endophthalmitis: Clinical Settings, Antibiotic Susceptibility, and Management Outcomes

et al. 2021

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Enterococcus faecalis is known to cause severe acute endophthalmitis and often leads to poor visual outcomes in most ophthalmic infections. This retrospective study is to report the clinical settings, antimicrobial susceptibility patterns, and visual outcome of E. faecalis endophthalmitis at a tertiary referral institution in Taoyuan, Taiwan. E. faecalis endophthalmitis was diagnosed in 37 eyes of 37 patients. Post-cataract surgery was the most common cause (n = 27, 73%), followed by bleb-associated (n = 3, 8%), endogenous (n = 2, 5%), corneal ulcer-related (n = 2, 5%), post-vitrectomy (n = 1, 3%), post-pterygium excision (n = 1, 3%), and trauma (n = 1, 3%). Visual acuities upon presentation ranged from counting fingers to no light perception. Pars plana vitrectomy with intravitreal antibiotics were performed in 23 eyes (76%) as primary or secondary treatment. All isolates (37/37, 100%) were sensitive to vancomycin, penicillin, ampicillin, and teicoplanin. Six of 22 eyes (27%) were resistant to high-level gentamicin (minimum inhibitory concentration > 500 mg/L). Final visual acuities were better than 20/400 in 11 eyes (30%), 5/200 to hand motions in 4 eyes (11%), and light perception to no light perception in 22 eyes (59%). Three eyes were treated with evisceration. Compared with non-cataract subgroups, the post-cataract subgroup showed a significant difference of better visual prognosis (p = 0.016).

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Section: Discussionsupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

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Enterococcus faecalis Endophthalmitis: Clinical Settings, Antibiotic Susceptibility, and Management Outcomes

et al. 2021

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“…In addition, F. prausnitzii is one of the most common members of the gut microbiota of humans and other mammals, and has been shown to boost the host immune system (Miquel et al., ). However, species from Enterococcus are commonly associated with child's Broomstick and hypodermic injury (Rishi et al., ), enterococcal infections and bacteraemia (Cho et al., ; Reid, Cockerill & Patel, ). The relative abundance of Anaerofilum in faecal microbiota of children with autism and pervasive developmental disorder was significantly increased compared with that in healthy individuals (De Angelis et al., ).…”

Section: Resultsmentioning

confidence: 99%

Opportunistic pathogens are abundant in the gut of cultured giant spiny frog (Paa spinosa )

Wang³

et al. 2018

Aquac Res

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Pathogen infection poses a serious threat to the survival and commercial quality of cultured Paa spinosa, which provide protection as a substitute for wild P. spinosa. The gut microbiota plays vital roles in host health and immunity. To provide guidance for preventing intestinal diseases of artificial P. spinosa culture, we compared gut microbiota compositions of wild and cultured P. spinosa using high‐throughput sequencing. A total of 11,526 operational taxonomic units (OTUs) were identified from 14,043 sequences from each sample. Cetobacterium, PW3 Bacteroides and some unidentified species from Bacteroidales, Rikenellaceae and Clostridiales were significantly increased in the gut microbiota from cultured P. spinosa, whereas Faecalibacterium and unidentified bacteria from Ruminococcaceae were significantly decreased in the gut microbiota from cultured P. spinosa. According to the gut microbiota composition, we hypothesized that the cultured P. spinosa in Jing'an would exhibit a higher risk of pathogenic infection than those in Cili. These results provided a method to forecast the pathogenic infection risk of cultured P. spinosa, which could guide the artificial culture of and prevent diseases in P. spinosa through gut microbiota.

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“…Recent reports on pediatric endophthalmitis mostly focused on endophthalmitis due to a specific etiology such as pediatric cataract surgery [8], trauma [3,9], and endogenous infection [6] or focused on a specific type of endophthalmitis caused by a certain pathogen [10]. Only a few studies focused on pediatric endophthalmitis from all causes.…”

Section: Introductionmentioning

confidence: 99%

Etiology, microbiological isolates, and antibiotic susceptibilities in culture-proven pediatric endophthalmitis: a 9-year review

Yang

Lin

et al. 2020

Graefes Arch Clin Exp Ophthalmol

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Purpose To analyze the etiology, microbiological isolates, and antibiotic susceptibilities of endophthalmitis in pediatric patients. Methods Patients aged < 18 years with culture-positive endophthalmitis in Zhongshan Ophthalmic Center between January 2010 and December 2018 were included retrospectively. Results A total of 127 patients (127 eyes) were included, and 108 (85%) had posttraumatic endophthalmitis. Streptococcus (21.4%), coagulase-negative Staphylococcus (14.5%), Aspergillus (6.9%), and Bacillus cereus (5.3%) were the common organisms. The proportion of Streptococcus decreased with age (40.0% in 0-3 years, 16.3% in 4-12 years, and 6.3% in 13-17 years), while coagulase-negative Staphylococcus increased from 5.7% to 18.8%. Overall, fluoroquinolones achieved the highest antibiotic susceptibility rate (> 95%), while the susceptibility of isolated bacteria to tobramycin and cefazolin was only 60.2% and 59.4%, respectively. The susceptibility rates of Gram-positive cocci to cephalosporins were nearly 90%. For Gram-negative bacilli, susceptibility to neomycin was 91.3%. Conclusion Trauma was the main etiology for pediatric endophthalmitis. Although Streptococcus was the most prevalent organism in general, the dominant pathogen varied with age, which merits clinical attention. Fluoroquinolones showed the highest antibiotic efficacy; however, commonly used antibiotics tobramycin and cefazolin showed relatively low antibiotic susceptibility. Thus, antibiotic resistance in pediatric populations merits clinical attention.

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Enterococcus faecalis Endophthalmitis in Children – A 21 Year Study

Abstract: EFE in children is rare; seen with broom stick and needle injuries, if managed early recovers optimum vision.

Cited by 5 publications

References 29 publications

Enterococcus faecalis Endophthalmitis: Clinical Settings, Antibiotic Susceptibility, and Management Outcomes

Enterococcus faecalis Endophthalmitis: Clinical Settings, Antibiotic Susceptibility, and Management Outcomes

Opportunistic pathogens are abundant in the gut of cultured giant spiny frog (Paa spinosa )

Etiology, microbiological isolates, and antibiotic susceptibilities in culture-proven pediatric endophthalmitis: a 9-year review

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