I feel what I do: Relating interoceptive processes and reward-related behavior

Marshall, Amanda C.; Gentsch, Antje; Blum, Anna-Lucia; Broering, Christina; Schütz‐Bosbach, Simone

doi:10.1016/j.neuroimage.2019.02.032

Cited by 17 publications

(7 citation statements)

References 59 publications

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“…Remarkably, significant effects could only be found at the central frontal and the left frontal ROIs. This is in line with numerous findings showing that greatest modulation of HEP activity can be found on fronto-central electrodes and that it decreases with laterality (de la Fuente et al, 2019;García-Cordero et al, 2016;Leopold & Schandry, 2001;Marshall, Gentsch, Blum, Broering, & Schütz-Bosbach, 2019;Salamone et al, 2018;Schandry & Montoya, 1996;Yoris et al, 2018). Considering these findings alongside our behavioral results, we propose that nVNS activates key areas of the interoceptive network and modulates putative neurophysiological markers.…”

Section: Discussionsupporting

confidence: 92%

Behavioral and neurophysiological signatures of interoceptive enhancements following vagus nerve stimulation

Richter

García

Arriagada

et al. 2020

Human Brain Mapping

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An accruing body of research has shown that interoception (the sensing of signals from the body's internal milieu) relies on both a direct route (afforded by the vagus nerve) and a secondary route (supported by somatosensory mechanisms). However, no study has causally tested the differential role of these pathways, let alone via direct stimulation. To bridge this gap, we tested whether multidimensional signatures of interoception are modulated by noninvasive vagus nerve stimulation (nVNS). Sixty‐three participants were divided into an nVNS and a sham‐stimulation group. Before and after stimulation, both groups performed a validated heartbeat detection (HBD) task including a genuinely interoceptive condition (monitoring one's own heartbeat) and a control exteroceptive condition (tracking an aurally presented heartbeat). Electroencephalographic signals were obtained during both conditions to examine modulations of the heartbeat‐evoked potential (HEP). Moreover, before and after stimulation, participants were asked to complete a somatosensory heartbeat localization task. Results from the interoceptive condition revealed that, after treatment, only the nVNS group exhibited improved performance and greater HEP modulations. No behavioral differences were found for the exteroceptive control condition, which was nonetheless associated with significant HEP modulations. Finally, no between‐group differences were observed regarding the localization of the heartbeat sensations or relevant cardiodynamic variables (heart rate and or heart rate variability). Taken together, these results constitute unprecedented evidence that the vagus nerve plays a direct role in neurovisceral integration during interoception. This finding can constrain mechanistic models of the domain while informing a promising transdiagnostic agenda for interoceptive impairments across neuropsychiatric conditions.

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Section: Discussionsupporting

confidence: 92%

Behavioral and neurophysiological signatures of interoceptive enhancements following vagus nerve stimulation

Richter

García

Arriagada

et al. 2020

Human Brain Mapping

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“…states that are associated with outcome valence facilitates motor execution and outcome evaluation (Marshall et al, 2019). Therefore, interoceptive processing is considered crucial for action generation, control, and self-attribution of action ).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, our actions and decisions are influenced by interoceptive processes and may also, themselves, have important interoceptive consequences (Quattrocki & Friston, 2014 ). Indeed, recent evidence provides a link between interoceptive and motor mechanisms, whereby accurate anticipation of the homeostatic feeling states that are associated with outcome valence facilitates motor execution and outcome evaluation (Marshall et al, 2019 ). Therefore, interoceptive processing is considered crucial for action generation, control, and self-attribution of action (Marshall, Gentsch, & Schütz-Bosbach, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Feeling in Control: The Role of Cardiac Timing in the Sense of Agency

Herman

Tsakiris

2020

Affec Sci

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The sense of agency describes the experience of controlling one’s body to cause desired effects in the world. We explored whether this is influenced by interoceptive processes. Specifically, we investigated whether the sense of agency changes depending on where, in the cardiac cycle (systole or diastole), the action was executed and where the outcome of the action occurred. In two experiments, participants completed decision-making task to win/lose money. Explicit (ratings of control) and implicit (temporal judgement) measures of agency were differentially affected by cardiovascular state. Implicit agency scores were affected by the cardiac phase at the point of action execution. Explicit ratings of control were affected by the type of (free vs. instructed) and by outcome valence (win vs. lose). The time of the action was uniformly distributed across the cardiac cycle. These results show interoceptive impact on agency, but that cardiac cycle may affect explicit and implicit agency differently.

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“…By establishing a link between citalopram and interoception, the field has a new grounding for research exploring a common thread between seemingly distinct effects of serotonergic drugs, each of which has been independently linked to both interoception and serotonin, including: incentive processing (Marshall et al 2019 ; Michely et al 2020 ), decision-making (Werner et al 2009 ; Crockett et al 2010 ), response inhibition (Rae et al 2018 ; Skandali et al 2018 ), startle (Grillon et al 2007 ; Schulz et al 2016 ), and threat perception (Harmer and Cowen 2013 ; Garfinkel and Critchley 2016 ).…”

Section: Discussionmentioning

confidence: 99%

A single oral dose of citalopram increases interoceptive insight in healthy volunteers

et al. 2022

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Rationale Interoception is the signalling, perception, and interpretation of internal physiological states. Many mental disorders associated with changes of interoception, including depressive and anxiety disorders, are treated with selective serotonin reuptake inhibitors (SSRIs). However, the causative link between SSRIs and interoception is not yet clear. Objectives To ascertain the causal effect of acute changes of serotonin levels on cardiac interoception. Methods Using a within-participant placebo-controlled design, forty-seven healthy human volunteers (31 female, 16 male) were tested on and off a 20 mg oral dose of the commonly prescribed SSRI, citalopram. Participants made judgements on the synchrony between their heartbeat and auditory tones and then expressed confidence in each judgement. We measured three types of interoceptive cognition. Results Citalopram increased cardiac interoceptive insight, measured as correspondence of self-reported confidence to the likelihood that interoceptive judgements were actually correct. This effect was driven by enhanced confidence for correct interoceptive judgements and was independent of measured cardiac and reported subjective effects of the drug. Conclusions An acute change of serotonin levels can increase insight into the reliability of inferences made from cardiac interoceptive sensations.

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I feel what I do: Relating interoceptive processes and reward-related behavior

Cited by 17 publications

References 59 publications

Behavioral and neurophysiological signatures of interoceptive enhancements following vagus nerve stimulation

Behavioral and neurophysiological signatures of interoceptive enhancements following vagus nerve stimulation

Feeling in Control: The Role of Cardiac Timing in the Sense of Agency

A single oral dose of citalopram increases interoceptive insight in healthy volunteers

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