<i>Ganoderma</i>
            polysaccharide and chitosan synergistically ameliorate lipid metabolic disorders and modulate gut microbiota composition in high fat diet‐fed golden hamsters

Tong, Aijun; Hu, Rongkang; Wu, Linxiu; Lv, Xu-Cong; Li, Xin; Zhao, Liang; Liu, Bin

doi:10.1111/jfbc.13109

Cited by 51 publications

(29 citation statements)

References 42 publications

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“…Phylogenic analysis established a strong inverse correlation between Lactobacillus rhamnosus and plasma cholesterol and LDL-C levels. Interestingly, decreases in plasma cholesterol levels associated with acarbose treatment were associated with a decline in allistipes spp., in accordance with recent studies (Le Roy et al, 2019;Tong et al, 2019).…”

Section: Secondary Bile Acidssupporting

confidence: 94%

“…Several bacterial phylotypes affiliated with Betaproteobacteria phylum, Alistipes genus, and Barnesiella genus were enriched in hypercholesterolemic mouse recipients. Similarly, Alistipes were recently associated with TC and LDL-C in HFD-fed hamsters treated with a chitin9-derived polysaccharide (chitosan) (Tong et al, 2019).…”

Section: Gut Microbiota and Cholesterol Traits In Preclinical Modelsmentioning

confidence: 89%

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Unraveling Host-Gut Microbiota Dialogue and Its Impact on Cholesterol Levels

Villette

Béliard

et al. 2020

Front. Pharmacol.

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Disruption in cholesterol metabolism, particularly hypercholesterolemia, is a significant cause of atherosclerotic cardiovascular disease. Large interindividual variations in plasma cholesterol levels are traditionally related to genetic factors, and the remaining portion of their variance is accredited to environmental factors. In recent years, the essential role played by intestinal microbiota in human health and diseases has emerged. The gut microbiota is currently viewed as a fundamental regulator of host metabolism and of innate and adaptive immunity. Its bacterial composition but also the synthesis of multiple molecules resulting from bacterial metabolism vary according to diet, antibiotics, drugs used, and exposure to pollutants and infectious agents. Microbiota modifications induced by recent changes in the human environment thus seem to be a major factor in the current epidemic of metabolic/inflammatory diseases (diabetes mellitus, liver diseases, inflammatory bowel disease, obesity, and dyslipidemia). Epidemiological and preclinical studies report associations between bacterial communities and cholesterolemia. However, such an association remains poorly investigated and characterized. The objectives of this review are to present the current knowledge on and potential mechanisms underlying the host-microbiota dialogue for a better understanding of the contribution of microbial communities to the regulation of cholesterol homeostasis.

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Section: Secondary Bile Acidssupporting

confidence: 94%

Section: Gut Microbiota and Cholesterol Traits In Preclinical Modelsmentioning

confidence: 89%

Unraveling Host-Gut Microbiota Dialogue and Its Impact on Cholesterol Levels

Villette

Béliard

et al. 2020

Front. Pharmacol.

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“…In contrast, the abundance of the Alistipes genus was significantly decreased in the HL group compared to HC. The abundance of Alistipes , which belongs to the Bacteroidetes phylum, was lower in rodent models with high fat diet-induced hyperlipidemia [ 28 , 29 ]. In addition, the levels of this genus were also significantly decreased in obese Mexican individuals [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Changes in the Gut Microbiota are Associated with Hypertension, Hyperlipidemia, and Type 2 Diabetes Mellitus in Japanese Subjects

et al. 2020

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The human gut microbiota is involved in host health and disease development. Therefore, lifestyle-related diseases such as hypertension (HT), hyperlipidemia (HL), and type 2 diabetes mellitus (T2D) may alter the composition of gut microbiota. Here, we investigated gut microbiota changes related to these diseases and their coexistence. This study involved 239 Japanese subjects, including healthy controls (HC). The fecal microbiota was analyzed through the isolation of bacterial genomic DNA obtained from fecal samples. Although there were no significant differences in the microbial structure between groups, there was a significant difference in the α-diversity between HC and the patients in whom two diseases coexisted. Moreover, Actinobacteria levels were significantly increased, whereas Bacteroidetes levels were significantly decreased in all disease groups. At the genus level, Bifidobacterium levels were significantly increased in the HL and T2D groups, as were those of Collinsella in all disease groups. In contrast, Alistipes levels were significantly lower in the HL group. Furthermore, metabolic enzyme families were significantly increased in all disease groups. Interestingly, the structure and function of the gut microbiota showed similar profiles in all the studied diseases. In conclusion, several changes in the structure of the gut microbiota are associated with T2D, HT, and HL in Japanese subjects.

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“…Contrariwise, Bacteroidetes species such as Bacteroides and Prevotella possess strong peptidase activity and are associated with isovalerate and isobutyrate production [88]. At genus level, chitosan was found to increase Prevotella [81], decrease Lactobacillus [79,81] and increase Bifidobacterium [74,79], as well as increasing Ruminococcus, Oscillibacter, Bifidobacterium, Prevotella, Alloprevotella and Paraprevotella [80]. All the variations at genus level, with the exception of the decrease in Lactobacillus, are considered beneficial to health because they include SCFA producers, such as Prevotellaceae and Oscillibacter, that produce anti-inflammatory metabolites, which subsequently regulate proinflammatory immune cells [89][90][91].…”

Section: Lactobacillus Rhamnosusmentioning

confidence: 99%

“…With respect to chitin derivatives, the results obtained can be found in Table 2. It includes works carried out in non-diabetic humans [73], in vitro trials [2,22,56,74,75], and in vivo trials using mice [46,57,76], rats [56,77,78], pigs [49,79], Syrian golden hamsters [80] and zebrafish [48]. Various types of chitin derivatives were included, such as chitosan [23,74,79], GC [56,73,76], NACOS [57], COS [2,23,46,50,75,77,78] and various different derivatives obtained from chitosan [48,49,80,81].…”

Section: Effect Of Chitin and Its Derivatives On Gut Microbiotamentioning

confidence: 99%

Animal-Origin Prebiotics Based on Chitin: An Alternative for the Future? A Critical Review

López-Santamarina

Mondragón

Lamas

et al. 2020

Foods

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The human gut microbiota has been revealed in recent years as a factor that plays a decisive role in the maintenance of human health, as well as in the development of many non-communicable diseases. This microbiota can be modulated by various dietary factors, among which complex carbohydrates have a great influence. Although most complex carbohydrates included in the human diet come from vegetables, there are also options to include complex carbohydrates from non-vegetable sources, such as chitin and its derivatives. Chitin, and its derivatives such as chitosan can be obtained from non-vegetable sources, the best being insects, crustacean exoskeletons and fungi. The present review offers a broad perspective of the current knowledge surrounding the impacts of chitin and its derived polysaccharides on the human gut microbiota and the profound need for more in-depth investigations into this topic. Overall, the effects of whole insects or meal on the gut microbiota have contradictory results, possibly due to their high protein content. Better results are obtained for the case of chitin derivatives, regarding both metabolic effects and effects on the gut microbiota composition.

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Ganoderma polysaccharide and chitosan synergistically ameliorate lipid metabolic disorders and modulate gut microbiota composition in high fat diet‐fed golden hamsters

Cited by 51 publications

References 42 publications

Unraveling Host-Gut Microbiota Dialogue and Its Impact on Cholesterol Levels

Unraveling Host-Gut Microbiota Dialogue and Its Impact on Cholesterol Levels

Changes in the Gut Microbiota are Associated with Hypertension, Hyperlipidemia, and Type 2 Diabetes Mellitus in Japanese Subjects

Animal-Origin Prebiotics Based on Chitin: An Alternative for the Future? A Critical Review

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