Hypericum spp.: An Update on the Biological Activities and Metabolic Profiles

Abstract

: Plants from the genus Hypericum, one genus of the Hypericaceae family, have attracted a lot of attention for their potential pharmaceutical applications. Most of the studies in the literature focus on H. perforatum L. (common St. John's wort), whose complex spectrum of bioactive compounds makes this species one of the top herbal remedies and supplements in the world. It is also important to compare the studies on other Hypericum species, both from the phytochemical and biological point of view. The aim of this review was to provide an update of most recent studies about biological investigations of plants belonging to Hypericum genus. The metabolic profiles of Hypericum spp. were also discussed in order to present a spectrum of secondary metabolites not previously identified in this genus.

Hypericum genus cosmeceutical application – A decade comprehensive review on its multifunctional biological properties

“…Hence, it is essential to find alternative ingredients with fewer side effects and active wound healing properties. Natural biomolecules have demonstrated wound healing properties mainly due to their potential to target multiple signalling pathways and effectively enhance fibroblast proliferation and migration, angiogenesis promotion, and suppression of inflammatory mediators overproduction (Beißner et al, 2018;Marrelli et al, 2019;Montoya et al, 2015). Extracts from .…”

Drug- and toxin-induced pulmonary arterial hypertension: Current state of the literature

“…St. John's wort is a plant from the genus Hypericum, with a complex spectrum of bioactive compounds, and is one of the most commonly used herbal remedies and supplements in the world (120). St. John's wort is an over-the-counter supplement that has been used as an adjuvant for the treatment of major depression (121), as well as an aid for weight loss and treatment of obesity (122).…”

Norprzewalsone A, a Rearranged Polycyclic Polyprenylated Acylphloroglucinol with a Spiro[cyclopentane-1,3′-tricyclo[7.4.0.01,6]tridecane] Core from Hypericum przewalskii

“…1−3 With striking structural diversity, PPAPs were reported to possess a wide variety of bioactivities, such as anti-inflammatory, antioxidant, anticancer, acetylcholinesterase inhibitory, and HIV preventive activities. 1,2,4 Because the typical PPAP, hyperforin, has been deemed to be a "star molecule" with outstanding antidepressant activity and neuroprotective effects against Alzheimer's disease, 1,5,6 PPAPs have attracted increasing attention from organic synthetic, pharmacological, and phytochemical fields. [1][2][3]7,8 Hypericum przewalskii is a traditional Chinese medicine applied to treat irregular menstruation, wounds, and bruises, and rheumatic pain in China.…”