In situ assembled titanium carbide-based heterojunctions for the synergistic enhancement of NIR-II photothermal/photodynamic therapy against breast cancer

Abstract

The combined use of photothermal therapy (PTT) and photodynamic therapy (PDT) could circumvent the drawbacks of each individual therapeutic strategy, resulting in an enhanced anti-tumor effect. However, the lack of...

A Ti3C2 MXene-integrated near-infrared-responsive multifunctional porous scaffold for infected bone defect repair

“…For instance, many previous studies have confirmed that MXenes can promote osteogenesis in mesenchymal stem cells. 24 Besides, the role of MXenes in antibacterial, 25–27 anti-tumor, 28,29 and ROS scavenging 30–32 has also been confirmed by previous studies.…”

Efficient photothermal conversion of MXenes and their application in biomedicine

“…MnO x /Ti 3 C 2 MXenes are used as multifunctional theranostic materials for MRI and PA dual-modality imaging to guide PTT of cancer. Zhu et al 155 prepared a composite of Ti 3 C 2 and TiO 2 by in situ assembly, and the heterojunction of Ti 3 C 2 and TiO 2 was used to synergistically enhance NIR-II PTT and photodynamic therapy (PDT) for breast cancer. The Ti 3 C 2 /TiO 2 heterojunction showed a PCE of up to 44.98% under NIR-II irradiation.…”

MXene‐Based Functional Platforms for Tumor Therapy

“…[105] Based on this, He et al constructed the Ti 3 C 2 /TiO 2 heterojunction and confirmed its better ROS production and photothermal effects under the illumination of 660 and 1064 nm laser when compared with TiO 2 nanomaterial or MXene alone (Figure 7B). [106] This phenomenon was attributed to the reduced bandgap of Ti 3 C 2 /TiO 2 heterojunction, which was able to promote the separation of e − -h + and prevent them from recombination, as well as enhanced absorption of Ti 3 C 2 /TiO 2 in the range of visible to NIR-II window. The research on exploring the application potentials of MXene in antitumor PDT is far from enough, and it is urgently needed to develop more MXene-based PDT sensitization strategies to further extend the biomedical applications of MXenes.…”

“…Reproduced with permission. [106] Copyright 2022, The Royal Society of Chemistry. [109] Copyright 2022, Wiley-VCH GmbH.…”