<i>In utero</i> sensitization modulates IgG isotype, IFN‐γ and IL‐10 responses of neonates in bancroftian filariasis

Achary, K. Gopinath; Mandal, Nityananda; Mishra, Suchismita; Mishra, Rashmi; Sarangi, Siddharth; Satapathy, Alok; Kar, S. K.; Bal, Madhusmita

doi:10.1111/pim.12121

Cited by 11 publications

(14 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a consequence the neonates born to the infected mother become more susceptible to infection [2, 13, 14]. We have observed filarial antigen in 21.4% (6/28) of the cord blood of infected mothers but 42.8% of children born to them have acquired filarial infection which is double the figure of antigenemia of cord blood.…”

Section: Discussionmentioning

confidence: 81%

Maternal Filarial Infection Influences the Development of Regulatory T Cells in Children from Infancy to Early Childhood

et al. 2016

View full text Add to dashboard Cite

BackgroundChildren born from filarial infected mothers are comparatively more susceptible to filarial infection than the children born to uninfected mothers. But the mechanism of such increased susceptibility to infection in early childhood is not exactly known. Several studies have shown the association of active filarial infection with T cell hypo-responsiveness which is mediated by regulatory T cells (Tregs). Since the Tregs develop in the thymus from CD4+ CD25hi thymocytes at an early stage of the human fetus, it can be hypothesized that the maternal infection during pregnancy affects the development of Tregs in children at birth as well as early childhood. Hence the present study was designed to test the hypothesis by selecting a cohort of pregnant mothers and children born to them subsequently in a filarial endemic area of Odisha, India.Methodology and Principal findingA total number of 49 pregnant mothers and children born to them subsequently have been followed up (mean duration 4.4 years) in an area where the microfilariae (Mf) rate has come down to <1% after institution of 10 rounds of annual mass drug administration (MDA). The infection status of mother, cord and children were assessed through detection of microfilariae (Mf) and circulating filarial antigen (CFA). Expression of Tregs cells were measured by flow cytometry. The levels of IL-10 were evaluated by using commercially available ELISA kit. A significantly high level of IL-10 and Tregs have been observed in children born to infected mother compared to children of uninfected mother at the time of birth as well as during early childhood. Moreover a positive correlation between Tregs and IL-10 has been observed among the children born to infected mother.SignificanceFrom these observations we predict that early priming of the fetal immune system by filarial antigens modulate the development of Tregs, which ultimately scale up the production of IL-10 in neonates and creates a milieu for high rate of acquisition of infection in children born to infected mothers. The mechanism of susceptibility and implication of the results in global elimination programme of filariasis has been discussed.

show abstract

Section: Discussionmentioning

confidence: 81%

Maternal Filarial Infection Influences the Development of Regulatory T Cells in Children from Infancy to Early Childhood

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Likewise, transplacental transfer of circulating antigens has been also documented in other parasitic diseases such as lymphatic filariasis 43, 44 . However, in the present study high maternal parasite densities do not always correlated with high Pf HRP2 levels and positive RDT and/or ELISA results suggesting that transplacental passage of parasite antigens can be influenced by different conditions during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Diagnosing congenital malaria in a high-transmission setting: clinical relevance and usefulness of P. falciparum HRP2-based testing

Natama

Ouedraogo

Sorgho

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Congenital malaria diagnosis is challenging due to frequently observed low parasite density infections, while their clinical relevance during early infancy is not well characterized. In Nanoro health district (Burkina Faso), we determined the prevalence of congenital malaria by real-time quantitative PCR and we assessed the performance of rapid diagnosis test (RDT) and light microscopy (LM) to detect Plasmodium falciparum infections in cord-blood samples. In addition, we examined the usefulness of P. falciparum Histidine Rich Protein2 (PfHRP2) as surrogate biomarker of infection and explored association between congenital malaria and clinical outcomes. A prevalence of congenital malaria by qPCR of 4% (16/400) was found, which increased to 10% among newborns from mothers infected at delivery. RDT and LM showed poor performances indicating limited utility for congenital malaria screening in cord blood. Because PfHRP2 detection in cord blood could be affected by transplacental passage of parasite antigens, PfHRP2 might not be used as a surrogate biomarker of congenital malaria infections. There was no evidence of a significant clinical impact of congenital malaria on infant’s health from birth to 59 days of life. Case control studies including long-term follow up may provide additional understanding on the relevance of neonatal malaria infections.

show abstract

“…Although the reasons for this interesting IgG subclass pattern are not clear, it might be attributable to host genetic background, transmission intensity and other demographic and epidemiological factors. Of note, host cytokines such as IL-10 and IFN-γ could profoundly affect the malaria parasite-specific IgG3 and IgG4 [ 34 , 72 – 75 ].…”

Section: Discussionmentioning

confidence: 99%

Naturally Acquired Antibody Responses to Plasmodium vivax and Plasmodium falciparum Merozoite Surface Protein 1 (MSP1) C-Terminal 19 kDa Domains in an Area of Unstable Malaria Transmission in Southeast Asia

Wang

Zhao²,

Zhang

et al. 2016

PLoS ONE

View full text Add to dashboard Cite

Understanding naturally acquired immunity to infections caused by Plasmodia in different malaria endemicity settings is needed for better vaccine designs and for exploring antibody responses as a proxy marker of malaria transmission intensity. This study investigated the sero-epidemiology of malaria along the international border between China and Myanmar, where malaria elimination action plans are in place. This study recruited 233 P. vivax and 156 P. falciparum infected subjects with acute malaria at the malaria clinics and hospitals. In addition, 93 and 67 healthy individuals from the same endemic region or from non-endemic region, respectively, were used as controls. Acute malaria infections were identified by microscopy. Anti-recombinant PfMSP119 and PvMSP119 antibody levels were measured by ELISA. Antibody responses to respective MSP119 were detected in 50.9% and 78.2% patients with acute P. vivax and P. falciparum infections, respectively. There were cross-reacting antibodies in Plasmodium patients against these two recombinant proteins, though we could not exclude the possibility of submicroscopic mixed-species infections. IgG1, IgG3 and IgG4 were the major subclasses. Interestingly, 43.2% of the healthy endemic population also had antibodies against PfMSP119, whereas only 3.9% of this population had antibodies against PvMSP119. Higher antibody levels were correlated with age and parasite density, but not with season, gender or malaria history. Both total IgG and individual IgG subclasses underwent substantial declines during the convalescent period in three months. This study demonstrated that individuals in a hypoendemic area with coexistence of P. vivax and P. falciparum can mount rapid antibody responses against both PfMSP119 and PvMSP119. The significantly higher proportion of responders to PfMSP119 in the healthy endemic population indicates higher prevalence of P. falciparum in the recent past. Specific antibodies against PvMSP119 could serve as a marker of recent exposure to P. vivax in epidemiological studies.

show abstract

In utero sensitization modulates IgG isotype, IFN‐γ and IL‐10 responses of neonates in bancroftian filariasis

Cited by 11 publications

References 37 publications

Maternal Filarial Infection Influences the Development of Regulatory T Cells in Children from Infancy to Early Childhood

Maternal Filarial Infection Influences the Development of Regulatory T Cells in Children from Infancy to Early Childhood

Diagnosing congenital malaria in a high-transmission setting: clinical relevance and usefulness of P. falciparum HRP2-based testing

Naturally Acquired Antibody Responses to Plasmodium vivax and Plasmodium falciparum Merozoite Surface Protein 1 (MSP1) C-Terminal 19 kDa Domains in an Area of Unstable Malaria Transmission in Southeast Asia

Contact Info

Product

Resources

About