2024
DOI: 10.1021/acs.molpharmaceut.3c00806
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In Vitro Release from Polymeric Core/Shell Nanoparticles through the Lens of Multiscale Modeling

Tommaso Casalini,
Kevin Treacher,
Iain Grant
et al.

Abstract: The large number of studies involving nanoparticles for cancer therapy is due to their peculiar features: they protect loaded active molecules while extending circulation time and can extravasate from the blood flow to the tumor to deliver drugs directly in the target area. Mathematical modeling can provide a preliminary in silico exploration of design space to optimize an experimental activity that often relies on a trial-and-error approach. However, because of the characteristic size of these vectors (10− 10… Show more

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