<i>In vivo</i>analysis of the effects of CoCrMo and Ti particles on inflammatory responses and osteolysis

Li, Juehong; Li, Yamin; Peng, Xiaochun; Li, Bin; Qin, Hui; Chen, Yunsu

doi:10.1039/c7ra12325f

Cited by 5 publications

(17 citation statements)

References 43 publications

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“…The main biological factor is the biological response of cells to a variety of wear particles (21), for example, wear particles can promote macrophage polarization to M1, and release proinflammatory cytokines and chemokines (23,24). These cellular responses and subsequent activities are determined by many factors, such as the physical and chemical properties of the material, including the size, morphology, and composition of the material (23,(25)(26)(27)(28)(29). Moreover, the presence of endotoxin can also affect these cellular responses and activities (30)(31)(32).…”

Section: Pathogenesismentioning

confidence: 99%

Macrophages in aseptic loosening: Characteristics, functions, and mechanisms

et al. 2023

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Aseptic loosening (AL) is the most common complication of total joint arthroplasty (TJA). Both local inflammatory response and subsequent osteolysis around the prosthesis are the fundamental causes of disease pathology. As the earliest change of cell behavior, polarizations of macrophages play an essential role in the pathogenesis of AL, including regulating inflammatory responses and related pathological bone remodeling. The direction of macrophage polarization is closely dependent on the microenvironment of the periprosthetic tissue. When the classically activated macrophages (M1) are characterized by the augmented ability to produce proinflammatory cytokines, the primary functions of alternatively activated macrophages (M2) are related to inflammatory relief and tissue repair. Yet, both M1 macrophages and M2 macrophages are involved in the occurrence and development of AL, and a comprehensive understanding of polarized behaviors and inducing factors would help in identifying specific therapies. In recent years, studies have witnessed novel discoveries regarding the role of macrophages in AL pathology, the shifts between polarized phenotype during disease progression, as well as local mediators and signaling pathways responsible for regulations in macrophages and subsequent osteoclasts (OCs). In this review, we summarize recent progress on macrophage polarization and related mechanisms during the development of AL and discuss new findings and concepts in the context of existing work.

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Section: Pathogenesismentioning

confidence: 99%

Macrophages in aseptic loosening: Characteristics, functions, and mechanisms

et al. 2023

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“…80 Cr-Co-Mo, Ti alloy, and zirconium induce an inflammatory reaction in human osteoblasts, fibroblasts, and macrophages with the release of interleukin IL-1β, IL-6, tumor necrosis factor (TNF), and IL-8, which have all been shown to produce bone loss around orthopedic implants. 81,82 In summary, while all metal particles promote the high release of macrophage inflammatory mediators, Cr-Co-Mo, and titanium alloys lead to a higher inflammatory status. Macrophages in contact with Cr-Co-Mo release 100 times more IL-8 than controls, and fibroblasts and osteoblasts secrete 30 times more IL-6 and 15 times more TNFα than controls.…”

Section: Toxicityoftitaniumandpresenceof Metal Particlesmentioning

confidence: 99%

“…While RANKL is an activator of NF-kB signaling and can increase the inflammatory response, OPG is a competitive ligand of the RANKL receptor. 82 Titanium particles increases the RANKL/OPG balance in a dose-dependent manner by increasing the expression of RANKL and diminishing the expression of OPG. [89][90][91] CoCrMo particles have an even stronger effect on the RANKL/OPG ratio than Ti particles.…”

Section: Toxicityoftitaniumandpresenceof Metal Particlesmentioning

confidence: 99%

“…82 The larger intensity of proinflammatory mediators caused by Co-Cr-Mo particles can be explained by their more intense cellular response, whereas titanium particles induce a chronic inflammatory reaction with macrophage activation, proinflammatory cytokine release, and osteoclast differentiation and activation. 82 These Co-Cr-Mo particles can induce monocyte/macrophage activation and secretion of proinflammatory cytokines via upregulation of the transcription factor NF-κB; however, these particles not only activate macrophages but also stimulate T cells of the immune system and activate the inflammasome danger signaling pathway in human macrophages. 82,83,92,93 This local and systemic inflammation may lead to both a reduction in osteoblast function and higher osteoclast metabolism.…”

Section: Toxicityoftitaniumandpresenceof Metal Particlesmentioning

confidence: 99%

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Emerging factors affecting peri‐implant bone metabolism

Insua,

Galindo‐Moreno,

Miron

et al. 2023

Periodontology 2000

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Implant dentistry has evolved to the point that standard implant osseointegration is predictable. This is attributed in part to the advancements in material sciences that have led toward improvements in implant surface technology and characteristics. Nonetheless, there remain several cases where implant therapy fails (specifically at early time points), most commonly attributed to factors affecting bone metabolism. Among these patients, smokers are known to have impaired bone metabolism and thus be subject to higher risks of early implant failure and/or late complications related to the stability of the peri‐implant bone and mucosal tissues. Notably, however, emerging data have unveiled other critical factors affecting osseointegration, namely, those related to the metabolism of bone tissues. The aim of this review is to shed light on the effects of implant‐related factors, like implant surface or titanium particle release; surgical‐related factors, like osseodensification or implanted biomaterials; various drugs, like selective serotonin reuptake inhibitors, proton pump inhibitors, anti‐hypertensives, nonsteroidal anti‐inflammatory medication, and statins, and host‐related factors, like smoking, diet, and metabolic syndrome on bone metabolism, and aseptic peri‐implant bone loss. Despite the infectious nature of peri‐implant biological complications, these factors must be surveyed for the effective prevention and management of peri‐implantitis.

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“… 12 During osteoclast activation, titanium particles strongly trigger three major transcription factors, NFATc1, c-Fos and TRAP, which play key roles in the differentiation of osteoclast. 13 , 14 Osteoclasts (OC) inhibit the formation and activation of OC by competing with RANK and binding to RANKL. Both TNF-α and IL-1α can affect the expression of RANKL in osteoblasts, and regulate the formation and activation of OC.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-151a-3p Functions in the Regulation of Osteoclast Differentiation: Significance to Postmenopausal Osteoporosis

He¹,

Chen²,

Guo³

et al. 2021

CIA

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Background: Studies have found the pivotal role of miRNAs in the progression of postmenopausal osteoporosis (OP). However, the function of miRNAs in OP is unclear. This study aimed to explore the biological functions of microRNA-151a-3p in OP. Methods: RT-qPCR was employed to assess the expression of microRNA-151a-3p in serum isolated from OP patients and healthy controls. Dual-energy X-ray absorptiometry (DXA) was used to measure the bone mineral density (BMD) of the lumbar spine. The expression levels of c-Fos, NFATc1, and TRAP were tested by Western blot. Ovariectomized (OVX) rats were treated with antago microRNA-151a-3p or antago NC, and then serum and lumbar vertebrae were collected for ELISA and bone histomorphology analysis. Results: The expression of microRNA-151a-3p in postmenopausal women with osteoporosis was significantly up-regulated, and microRNA-151a-3p level was negatively correlated with BMD. During osteoclastogenesis, microRNA-151a-3p level was obviously increased. Overexpression of microRNA-151a-3p promoted the differentiation of RANKL-induced THP-1 and RAW264.7 cells into osteoclasts, whereas silencing of microRNA-151a-3p resulted in the opposite results. Silencing of microRNA-151a-3p in OVX rats altered osteoclastogenesis-related factors and raised BMD. Conclusion:MicroRNA-151a-3p could partly regulate osteoporosis by promoting osteoclast differentiation, and miRNA-151a-3p could be a potential therapeutic target for postmenopausal osteoporosis.

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In vivoanalysis of the effects of CoCrMo and Ti particles on inflammatory responses and osteolysis

Abstract: CoCrMo particles induced a more severe inflammatory response and greater osteolysis than Ti particles in vivo in mice.

Cited by 5 publications

References 43 publications

Macrophages in aseptic loosening: Characteristics, functions, and mechanisms

Macrophages in aseptic loosening: Characteristics, functions, and mechanisms

Emerging factors affecting peri‐implant bone metabolism

MicroRNA-151a-3p Functions in the Regulation of Osteoclast Differentiation: Significance to Postmenopausal Osteoporosis

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