In vivo evidence suggesting a role for purine‐catabolizing enzymes in the pathogenesis of cisplatin‐induced nephrotoxicity in rats and effect of erdosteine against this toxicity

Abstract

The aim of this experimental study was to investigate the possible role of adenosine deaminase (AD) and xanthine oxidase (XO) in the pathogenesis of cisplatin-induced nephrotoxicity and the effect of erdosteine in decreasing the toxicity. The intraperitoneal injection of cisplatin (7 mg kg(-1) body weight) induced a significant increase in plasma creatinine level and blood urea nitrogen (BUN), and plasma and damaged renal tissue activities of AD and XO in rats. Co-treatment with erdosteine (10 mg kg(-1)day(-1)) attenuated the increase in the plasma creatinine and BUN levels, and significantly prevented the increase in tissue and plasma AD and XO activities (P<0.05). The results of this study revealed that XO and AD may play an important role in the pathogenesis of cisplatin-induced nephrotoxicity. The potent free radical scavenger erdosteine may have protective potential in this process and it will become a promising drug in the prevention of this undesired side-effect of cisplatin, but further studies are needed to illuminate the exact protection mechanism of erdosteine against cisplatin-induced nephrotoxicity.

Hepatoprotective Potential of Lycopene in a Rat Model of Cisplatin-Induced Damage: Involvement of Oxidative Cell Damage and Glutathione Metabolism

“…These findings are especially important since XO is included in various pathophysiological processes [38,39] , but not in livers of rats treated with a 7 mg/kg of CP [40] . Interestingly enough the kidney XO was found to be increased by CP application [41] .…”

Protective Effect of Erdosteine against Cisplatin‐Induced Ototoxicity in a Guinea Pig Model

“…7 It has been observed that Met I is capable of reacting with reactive oxygen species, nitric oxide, and nitric oxide–derived peroxynitrite and furthermore has both antioxidant and scavenging activities. 18 Erdosteine has been shown to provide protection against cisplatin-induced nephrotoxicity 11,19-21 and cisplatin-induced hepatic oxidant injury 22 when given orally.…”

Biochemical and Histopathological Investigation of the Protective Effect of Lutein in Rat Kidney Exposed to Cisplatin

“…Studies have reported that Cis increases free radicals, causes damage to many tissues, and reduces protective activity against the effects of oxidative damage. Therefore, it is hypothesized that Cis-induced nephrotoxicity may result from increased oxidative stress from the increase of free oxygen radicals (9). As a result of various studies conducted in recent years, it has been shown that some side effects of Cis can be reduced without changing the effects of chemotherapy by applying antioxidants obtained by different methods (10,11).…”