<i>JAHA</i>
            Spotlight on Pregnancy and Its Impact on Maternal and Offspring Cardiovascular Health

Russell, Mark W.

doi:10.1161/jaha.121.025167

Cited by 2 publications

(4 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alterations in the RAAS can potentially affect fetal cardiovascular health in the short and long term [92]. Studies in rodents have shown that only male offspring exposed to PE had hypertension during young adulthood [93].…”

Section: Alterations In the Raasmentioning

confidence: 99%

“…The significance of the prenatal environment on the future health of offspring is already known. Since cardiovascular risk factors during pregnancy can directly affect the long-term cardiovascular health of the offspring, enhancing maternal health and the maternal-fetal environment becomes crucial in order to minimize the non-genetic or environmental transmission of cardiovascular risk from one generation to another [92]. The aim is to improve maternal-fetal health and for this reason, studies are needed to examine the effects of the treatment used in preeclamptic women [14].…”

Section: Future Directionsmentioning

confidence: 99%

See 1 more Smart Citation

The Molecular Basis of the Augmented Cardiovascular Risk in Offspring of Mothers with Hypertensive Disorders of Pregnancy

Svigkou,

Katsi,

Kordalis

et al. 2024

IJMS

View full text Add to dashboard Cite

The review examines the impact of maternal preeclampsia (PE) on the cardiometabolic and cardiovascular health of offspring. PE, a hypertensive disorder of pregnancy, is responsible for 2 to 8% of pregnancy-related complications. It significantly contributes to adverse outcomes for their infants, affecting the time of birth, the birth weight, and cardiometabolic risk factors such as blood pressure, body mass index (BMI), abdominal obesity, lipid profiles, glucose, and insulin. Exposure to PE in utero predisposes offspring to an increased risk of cardiometabolic diseases (CMD) and cardiovascular diseases (CVD) through mechanisms that are not fully understood. The incidence of CMD and CVD is constantly increasing, whereas CVD is the main cause of morbidity and mortality globally. A complex interplay of genes, environment, and developmental programming is a plausible explanation for the development of endothelial dysfunction, which leads to atherosclerosis and CVD. The underlying molecular mechanisms are angiogenic imbalance, inflammation, alterations in the renin–angiotensin–aldosterone system (RAAS), endothelium-derived components, serotonin dysregulation, oxidative stress, and activation of both the hypothalamic–pituitary–adrenal axis and hypothalamic–pituitary–gonadal axis. Moreover, the potential role of epigenetic factors, such as DNA methylation and microRNAs as mediators of these effects is emphasized, suggesting avenues for future research and therapeutic interventions.

show abstract

Section: Alterations In the Raasmentioning

confidence: 99%

Section: Future Directionsmentioning

confidence: 99%

The Molecular Basis of the Augmented Cardiovascular Risk in Offspring of Mothers with Hypertensive Disorders of Pregnancy

Svigkou,

Katsi,

Kordalis

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Globally, >1 billion people have hypertension. 1 Its prevalence has doubled over the past 3 decades 1 , 2 due to population aging, higher obesity rates, and lower physical activity levels. 3 Chronic hypertension–induced vascular injury contributes to heart disease and stroke in the longer term, 4 as well as the development of renal disease, retinopathy, dementia, and peripheral vascular disease.…”

mentioning

confidence: 99%

“…We evaluated both GHTN and preeclampsia, combined and separately, in relationship to the development of chronic hypertension. In contrast to other studies, we concurrently accounted for patterns of gestational diabetes (GD), 17 , 18 , 19 along with other adverse pregnancy complications associated with hypertension development (preterm delivery 2 , 20 and small [SGA] or large [LGA] for gestational age offspring 21 , 22 ). Pregnancy is a time when younger adults are interested in addressing health issues, to optimize the short‐ and long‐term health of the family.…”

mentioning

confidence: 99%

Patterns of Gestational Hypertension or Preeclampsia Across 2 Pregnancies in Relationship to Chronic Hypertension Development: A Retrospective Cohort Study

Mussa,

Rahme,

Dahhou

et al. 2024

JAHA

View full text Add to dashboard Cite

Background Gestational hypertension (GHTN) and preeclampsia are established risk indicators for chronic hypertension. While recurrence is associated with a greater risk, it is unclear whether there are differences in risk when these gestational complications occur for the first time in an earlier pregnancy versus first occurrence in a subsequent one. We hypothesized that the absence of recurrence reflects a transition toward a lower hypertension risk trajectory, whereas a new occurrence in a later pregnancy indicates a transition toward elevated risk. Methods and Results We analyzed linked data in Quebec, Canada, from public health care insurance administrative databases and birth, stillbirth, and death registries. Our retrospective cohort study included mothers with 2 singleton deliveries between April 1990 and December 2012. The primary exposure was patterns of GHTN or preeclampsia across 2 pregnancies (GHTN/preeclampsia in neither, first only, second only, or both). The outcome was incident chronic hypertension. We performed an adjusted multivariable Cox regression analysis. Among 431 980 women with 2 singleton pregnancies, 27 755 developed hypertension during the follow‐up period. Compared with those without GHTN/preeclampsia, those with GHTN/preeclampsia only in the first pregnancy had a 2.7‐fold increase in hazards (95% CI, 2.6–2.8), those with GHTN/preeclampsia only in the second had a 4.9‐fold increase (95% CI, 4.6–5.1), and those with GHTN/preeclampsia in both pregnancies experienced a 7.3‐fold increase (95% CI, 6.9–7.6). Patterns and estimates were similar when we considered GHTN and preeclampsia separately. Conclusions The magnitude of hypertension risk is associated with the number and sequence of GHTN/preeclampsia‐affected pregnancies. Considering both allows more personalized risk estimates.

show abstract

JAHA Spotlight on Pregnancy and Its Impact on Maternal and Offspring Cardiovascular Health

Cited by 2 publications

References 19 publications

The Molecular Basis of the Augmented Cardiovascular Risk in Offspring of Mothers with Hypertensive Disorders of Pregnancy

The Molecular Basis of the Augmented Cardiovascular Risk in Offspring of Mothers with Hypertensive Disorders of Pregnancy

Patterns of Gestational Hypertension or Preeclampsia Across 2 Pregnancies in Relationship to Chronic Hypertension Development: A Retrospective Cohort Study

Contact Info

Product

Resources

About