<i>Lactobacillus acidophilus</i> LA85 ameliorates cyclophosphamide-induced immunosuppression by modulating Notch and TLR4/NF-κB signal pathways and remodeling the gut microbiota

Xue, Liangyu; Li, Zongqi; Xue, Jiabao; Wang, Huanting; Wu, Tao; Li, Rui; Sui, Wenjie; Zhang, Min

doi:10.1039/d1fo04331e

Cited by 16 publications

(13 citation statements)

References 45 publications

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“… 24 This is similar to the research results of Jia et al. 25 Of interest, Erysipelatoclostridium 26 and Butyricicoccus 27 have also been shown to promote intestinal mucosal repair. Norank_f__ Ruminococcaceae 27 , 28 and Roseburia 29 enhance intestinal barrier function by upregulating TJ protein expression, and have anti-inflammatory potential.…”

Section: Discussionsupporting

confidence: 85%

Alteration of gut microbiome and metabolome by Clostridium butyricum can repair the intestinal dysbiosis caused by antibiotics in mice

Liu¹,

Qiu²,

Yang³

et al. 2023

iScience

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Section: Discussionsupporting

confidence: 85%

Alteration of gut microbiome and metabolome by Clostridium butyricum can repair the intestinal dysbiosis caused by antibiotics in mice

Liu¹,

Qiu²,

Yang³

et al. 2023

iScience

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“…66 CP also acts on tissue protein and affects tissue barrier integrity. 13,67 Thus, CP is potentially toxic even at non-lethal concentrations; toxicity is concentration dependent. 51 Recently, alterations in the biochemicals of Nile tilapia exposed to CP were also reported.…”

Section: Discussionmentioning

confidence: 99%

“…In the body, aer medication, CP could induce oxidative stress. 67 It was reported that the CP exposure could decrease antioxidant ability in the tissues of sh (Oreochromis niloticus). 63 ) and defends cells from oxidative damage.…”

Section: Discussionmentioning

confidence: 99%

“…In the body, after medication, CP could induce oxidative stress. 67 It was reported that the CP exposure could decrease antioxidant ability in the tissues of fish (Oreochromis niloticus). 63 Superoxide dismutase (SOD) is a very important antioxidant enzyme that scavenges free radicals induced by drugs/pollutants through catalysing superoxide anion radicals to hydrogen peroxide (H 2 O 2 ) and molecular oxygen (O 2 ) and defends cells from oxidative damage.…”

Section: Discussionmentioning

confidence: 99%

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A study to assess the health effects of an anticancer drug (cyclophosphamide) in zebrafish (Danio rerio): eco-toxicity of emerging contaminants

Hema

Sundaram

Umamaheswari

et al. 2023

Environ. Sci.: Processes Impacts

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“…18 Another study used Lactobacillus acidophilus LA85 to increase the expression of MATH-1. 19 The high level of MATH-1 expression can be attributed to an increase in stem cell activity, which in turn can lead to an increase in the activity of the secretory precursor. 13…”

Section: Groupsmentioning

confidence: 99%

Effect of Lactobacillus Plantarum IS-10506 on Paneth cell regeneration in the ileum of Sprague dawley rats

Hutama¹,

Athiyyah²,

Ranuh³

et al. 2023

Pharmacogn J.

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Background: Escherichia coli (E. coli) is the most common infectious agent among children in developing countries. Local probiotics are not widely used to treat diarrhea and intestinal infections. This study aims to investigate the cell regeneration process of Paneth cells after administration of Lactobacillus Plantarum IS-10506 due to damage caused by Lipopolysaccharide (LPS) E. coli O55:B5, through the expression of MATH-1 and DEFA6. Methods: This study used 64 paraffin blocks from Rattus norvegicus strain Spraque-Dawley divided into four groups. The KN group were administered a placebo. The KL group received LPS E. coli O55:B5 on day one. The KP group received LPS E. coli O55:B5 on the first day and Lactobacillus plantarum IS-10506 on the second day until six day. The KPR group were given Lactobacillus plantarum IS-10506 six days prior to receiving LPS E. coli O55:B5. All groups, except KN, received LPS at a dose of 250 μg/kg body weight once, and Lactobacillus plantarum IS-10506 at a dose of 2.86x10 6 CFU/day. Evaluating Paneth cell regeneration, DEFA6, and MATH-1 expression immunohistochemistry was conducted on all tissues. Results: The expression of DEFA6 and MATH-1 in the KP and KPR groups on day three of observation was significantly different from the KL group. Even though the KL group achieved significant growth, the results of this expansion were significantly smaller than KP and KPR groups. Conclusion: After mucosal injury caused by LPS E. coli 055:B5, administration of probiotic Lactobacillus plantarum IS-10506 may increase Paneth cell regeneration through differentiation and cell number.

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Lactobacillus acidophilus LA85 ameliorates cyclophosphamide-induced immunosuppression by modulating Notch and TLR4/NF-κB signal pathways and remodeling the gut microbiota

Abstract: With the prevalence of coronavirus disease 2019 (COVID-19), we found that probiotics may be effective in organism immune recovery and remodeling of gut microbiota in their patients and recovered individuals....

Cited by 16 publications

References 45 publications

Alteration of gut microbiome and metabolome by Clostridium butyricum can repair the intestinal dysbiosis caused by antibiotics in mice

Alteration of gut microbiome and metabolome by Clostridium butyricum can repair the intestinal dysbiosis caused by antibiotics in mice

A study to assess the health effects of an anticancer drug (cyclophosphamide) in zebrafish (Danio rerio): eco-toxicity of emerging contaminants

Effect of Lactobacillus Plantarum IS-10506 on Paneth cell regeneration in the ileum of Sprague dawley rats

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