<i>Latilactobacillus sakei</i> QC9 alleviates hyperglycaemia in high-fat diet and streptozotocin-induced type 2 diabetes mellitus mice <i>via</i> the microbiota–gut–liver axis

Chen, Mengling; Pan, Pengyuan; Zhang, Hongyan; Li, Rao; Ren, Dayong; Jiang, Bin

doi:10.1039/d4fo02316a

Food Funct.

2024

DOI: 10.1039/d4fo02316a

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Latilactobacillus sakei QC9 alleviates hyperglycaemia in high-fat diet and streptozotocin-induced type 2 diabetes mellitus mice via the microbiota–gut–liver axis

Mengling Chen,

Pengyuan Pan,

Hongyan Zhang

et al.

Abstract: Probiotics have been considered a promising option for mitigating the progression of type 2 diabetes mellitus (T2DM). Here, Latilactobacillus sakei QC9 (L. sakei QC9) with a hypoglycemic effect was screened...

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Editorial on amylase and the acini–islet–acinar reflex: A new frontier in metabolic health research

Deji-Oloruntoba,

Okpete,

Byeon

2025

World J Exp Med

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This editorial comments on the study by Pierzynowska et al investigating the acini-islet-acinar (AIA) reflex, which integrates the exocrine and endocrine functions of the pancreas. The study investigates whether exogenous amylase introduced to the interstitial fluid surrounding pancreatic islets can inhibit insulin release. Historically, high serum amylase levels were associated with pancreatitis, but recent findings suggest that low amylase levels are more linked to metabolic diseases like diabetes and obesity. In their experiment, six pigs were used to examine the effects of amylase infusion on insulin release during an intravenous glucose tolerance test. The pigs received different treatments (amylase, saline, or bovine serum albumin), and blood samples were taken over two hours to measure insulin and glucose levels. The results showed amylase delayed glucose-stimulated insulin release, whereas bovine serum albumin increased insulin levels supporting the existence of the AIA reflex and suggesting amylase as a key metabolic regulator. Enzyme supplementation, particularly with α-amylases, may offer therapeutic benefits in preventing and managing metabolic disorders, including diabetes and obesity. Further research is warranted to explore the full scope of amylase’s role in metabolic health and its therapeutic potential.

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Editorial on amylase and the acini–islet–acinar reflex: A new frontier in metabolic health research

Deji-Oloruntoba,

Okpete,

Byeon

2025

World J Exp Med

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show abstract

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Latilactobacillus sakei QC9 alleviates hyperglycaemia in high-fat diet and streptozotocin-induced type 2 diabetes mellitus mice via the microbiota–gut–liver axis

Abstract: Probiotics have been considered a promising option for mitigating the progression of type 2 diabetes mellitus (T2DM). Here, Latilactobacillus sakei QC9 (L. sakei QC9) with a hypoglycemic effect was screened...

Cited by 1 publication

References 90 publications

Editorial on amylase and the acini–islet–acinar reflex: A new frontier in metabolic health research

Editorial on amylase and the acini–islet–acinar reflex: A new frontier in metabolic health research

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