Lymphocyte Antigen 75 Polymorphisms Are Associated with Disease Susceptibility and Phenotype in Japanese Patients with Inflammatory Bowel Disease

Abstract

Recent genome-wide association studies have rapidly improved our understanding of the molecular pathways leading to inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC). Although several reports have demonstrated that gene single nucleotide polymorphisms (SNPs) are associated with susceptibility to IBD, its precise genetic factors have not been fully clarified. Here, we performed an association analysis between lymphocyte antigen 75 (LY75) genetic variations and IBD susceptibility or phenotype. SNPs were genotyped in 51 CD patients, 94 UC patients, and 269 healthy controls of Japanese ethnicity. We detected a significant relationship with CD susceptibility for the rs16822581 LY75 SNP (P = 0.045). One haplotype (GT, P = 0.042) was also associated with CD susceptibility, while another carrying the opposite SNP (CA) was linked to an absence of surgical history for CD. Our findings confirm that LY75 is involved in CD susceptibility and may play a role in disease activity in the Japanese population.

Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor

“…The remaining two significant variants in this locus are less common and are located in the nearby gene LY75 encoding the protein lymphocyte antigen 75. rs114821641-T causes a stop-gain mutation and an increase in suPAR (effect = 0.400; P = 1.08 × 10 −13 , EAF = 0.003), and rs755902185 is a deletion which causes a frameshift mutation in LY75 and an increase in suPAR (effect = 0.445; P = 1.05 × 10 −9 , EAF = 0.0004). Variants in LY75 have previously been associated with Inflammatory Bowel Syndrome and Crohn’s disease 36 , 37 . GO terms biological processes associated with the gene include endocytosis, immune response, and inflammatory response.…”

Procaspase-1 patrolled to the nucleus of proatherogenic lipid LPC-activated human aortic endothelial cells induces ROS promoter CYP1B1 and strong inflammation

“…L1CAM regulates microRNAs associated with inflammation and progression of Alzheimer's disease and Parkinson's disease [ 111 ]. Lymphocyte antigen 75 (LY75) polymorphisms are associated with susceptibility and phenotype of inflammatory bowel disease [ 112 ]. MUC1 promotes chronic inflammation and cancer [ 113 ].…”

Comparison of splenocyte microRNA expression profiles of pigs during acute and chronic toxoplasmosis

“…Previous research has reported that the expression of CD209 on macrophages activates phagocytosis, mediates DC rolling interactions with endothelium, activates CD4 + T cells and initiates innate immunity by modulating TLRs [53, 54]. LY75 expressed on CD8 + DCs plays a role in antigen processing and presentation in the context of both MHC class I and class II molecules and generates T helper 1-mediated immune responses through an IL-12-independent and CD70-dependent mechanism [55]. The roles of those C-type lectins need to be confirmed in T. gondii infection.…”