Minocycline attenuates testicular damages in a rat model of ischaemia/reperfusion (I/R) injury

Abstract

Testicular torsion is one of the most significant urological disorders in which the spermatic cord is twisted along the longitudinal axis and affects the male gender at any age; however, newborns, children and adolescent boys are the main target of the disease (Fehér & Bajory, 2016). Epidemiological studies indicated that testicular torsion occurs between the ages of 13 and 16 years and/or during the first year of life (Pogorelic, Mrklic, Juric, Biocic, & Furlan, 2013). The incidence of the spermatic cord torsion, in males with the age range of 1-25 years old, is estimated at 4.5 per 100,000 (Pogorelic et al., 2013). In this pathological condition, the blood flow to testes is considerably decreased, causing severe scrotal pain and tissue ischaemia. As widely accepted, both the duration and degree of twisting are the two most essential factors involved in testicular tissue damage. Therefore, early diagnosis and surgical interventions (i.e. testicular detorsion to retrieve the normal blood flow to the organ) are effective strategies to prevent (a) testicular injury, (b) loss of testicular germ cells and (c) finally infertility (Mellick, Sinex, Gibson, & Mears, 2019). In this regard, if the surgical procedure is carried out within 6 hr of pain onset, it would be feasible to save testicles by 90%-100%, while 12 and 24 hr after torsion, the survival rate of testicles would be reduced by 50% and 0%-10% respectively (

Minocycline can reduce testicular apoptosis related to varicocele in male rats

“…Prior investigations documented that the antioxidant enzymes can compensate for the destructive effect of free radical molecules by inhibiting mechanisms, and protect the testicular tissue from the ROS damages (Lanzafame et al, 2009). In correspondent with our study, Mahdi Azarabadi et al demonstrated that the administration of Minocycline could decrease the testicular apoptosis, ischaemia and reperfusion damage through decreasing the level of MDA as well as increasing the level of SOD (Azarabadi et al, 2020). Also Khaled Radad et al reported in a study that Minocycline improved neuronal degeneration and seminiferous tubular damage and reduced malondialdehyde levels.…”

“…In correspondent with our study, Mahdi Azarabadi et al demonstrated that the administration of Minocycline could decrease the testicular apoptosis, ischaemia and reperfusion damage through decreasing the level of MDA as well as increasing the level of SOD (Azarabadi et al, 2020). Also Khaled Radad et al reported in a study that Minocycline improved neuronal degeneration and seminiferous tubular damage and reduced malondialdehyde levels.…”

“…Mahdi Azarabadi et al show in their study that Minocycline administration could also decrease the rate of apoptosis in germ cells (TUNEL staining). Therefore, minocycline was beneficial in the management of testicular ischaemia/reperfusion (Azarabadi et al, 2020).…”

“…Therefore, minocycline was beneficial in the management of testicular ischaemia/reperfusion (Azarabadi et al, 2020).…”

DeepR2cov: deep representation learning on heterogeneous drug networks to discover anti-inflammatory agents for COVID-19

“…Based on PubMed publications, we also explore the potential mechanism of these drugs for the treatment of MERS. Minocycline suppresses the release of IL-1β by reducing the mRNA expression [ 69 ]. Azithromycin significantly inhibits IL-1β secretion by destabilizing mRNA levels and a dose-dependent manner [ 70–71 ].…”