<i>Mycobacterium haemophilum</i>as the Initial Presentation of a B-Cell Lymphoma in a Liver Transplant Patient

Doherty, Thomas J; Lynn, Merissa Sherrill; Cavazza, Alberto; Sames, E.; Hughes, Rod

doi:10.1155/2014/742978

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…However, it is clear that there are differences in virulence and immune response to different species, evidenced by species variations in the predominant site of infection and the fact that several species, including M. haemophilum and M. genavense , cause infection almost exclusively in immunocompromised patients. 18-20 The various settings of immunosuppression that are related to NTM infection are summarized in Table 1 and described in more detail in their respective sections.…”

Section: Disease Descriptionmentioning

confidence: 99%

Nontuberculous Mycobacteria Infections in Immunosuppressed Hosts

Henkle

Winthrop

2015

Clinics in Chest Medicine

258

205

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Synopsis Diseases and therapies that reduce cell-mediated immunity increase the risk of nontuberculous mycobacterial (NTM) disease. Historically acquired immunodeficiency virus (AIDS), cancer, and hematologic and solid organ transplants have been associated with NTM disease. More recently, immunosuppressive drugs including anti-tumor necrosis factor (anti-TNF) biologics have been associated with NTM disease in population-based studies. Extrapulmonary NTM disease, including disseminated and skin and catheter-related disease, is more common in immunosuppressed compared to immunocompetent patients. Mycobacterium avium complex remains the most common cause of NTM infection of all sites, but rapid growers including M. abscessus, M. chelonae, and M. fortuitum play an important role in skin and catheter-related infections. With the exception of prophylaxis for AIDS patients with very low CD4+ counts, the prevention of NTM remains difficult. Management is complicated and involves restoring immune function and removing catheters in addition to treatment with species-specific antibiotic treatment per current ATS/IDSA guidelines.

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Section: Disease Descriptionmentioning

confidence: 99%

Nontuberculous Mycobacteria Infections in Immunosuppressed Hosts

Henkle

Winthrop

2015

Clinics in Chest Medicine

258

205

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“…To date, there are only 21 cases of NTM reported among liver transplant recipients [3], [53], [76], [96], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], despite the increasing volume of liver transplantations. The underlying reason for the rarity of NTM cases among liver transplant cases is not known.…”

Section: Clinical Presentationmentioning

confidence: 99%

Non-tuberculous mycobacterial infections in solid organ transplant recipients: An update

Abad

Razonable

2016

Journal of Clinical Tuberculosis and Other Mycobacterial Diseas

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Non-tuberculous mycobacteria are ubiquitous environmental organisms that are now increasingly recognized as important causes of clinical disease in solid organ transplant recipients. Risk factors of non-tuberculous mycobacteria infection are severe immunologic defects and structural abnormalities. Lung transplant recipients are at higher risk for non-tuberculous mycobacterial disease compared to recipients of other solid organs. The clinical presentation could be skin and soft tissue infection, osteoarticular disease, pleuropulmonary infection, bloodstream (including catheter-associated) infection, lymphadenitis, and disseminated or multi-organ disease. Management of non-tuberculous mycobacteria infection is complex due to the prolonged treatment course with multi-drug regimens that are anticipated to interact with immunosuppressive medications. This review article provides an update on infections due to non-tuberculous mycobacteria after solid organ transplantation, and discusses the epidemiology, risk factors, clinical presentation, and management.

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Mycobacterium haemophilum infection with cutaneous involvement: two case reports and an updated literature review

Yasen,

Liu,

Mei

et al. 2023

J Deutsche Derma Gesell

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SummaryMycobacterium haemophilum (MH) is a slow‐growing, non‐tuberculous Mycobacterium that most commonly causes infections in immunocompromised patients. The skin is the most prevalent site of infection and can be an isolated presentation or part of a disseminated disease. Herein, we reported a case of isolated MH infection of the hand and a case of disseminated MH infection with multiple skin lesions. In addition, other MH cases with cutaneous involvement over the last 10 years, from 2011–2022, were reviewed and analyzed. Among the 79 included cases, the common skin findings in MH infections included nodules, ulcers, abscesses, swelling, and pustules. Middle‐aged patients with iatrogenic immunosuppression from glucocorticoids, mycophenolate mofetil, cyclosporine, and cyclophosphamide are the most susceptible to MH infection, with a higher risk of dissemination to internal organs. Disseminated MH infections commonly present as tenosynovitis, arthritis/arthralgia, or osteomyelitis. There is a lack of strong evidence for treatment; however, triple therapy of quinolone, macrolides, and rifampicin is most often used in clinical practice. The overall prognosis is good. The presence of iatrogenic immunocompromised diseases, lesions involving the proximal limbs, and dissemination of MH infections are associated with worse clinical outcomes.

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Mycobacterium haemophilumas the Initial Presentation of a B-Cell Lymphoma in a Liver Transplant Patient

Cited by 5 publications

References 24 publications

Nontuberculous Mycobacteria Infections in Immunosuppressed Hosts

Nontuberculous Mycobacteria Infections in Immunosuppressed Hosts

Non-tuberculous mycobacterial infections in solid organ transplant recipients: An update

Mycobacterium haemophilum infection with cutaneous involvement: two case reports and an updated literature review

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