<i>N</i>-(2-Nitrooxyethyl)picolinamide

Paixão, Drielly A.; Guilardi, Silvana; A, de Fátima; Dp, Araujo; Fc, Oliveira

doi:10.1107/s1600536811039572

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“…Following the treatments, animal mortality was assessed every 24 hours. After 96 hours, the number of dead sh in each group was recorded [17].…”

Section: Acute Toxicity (96 H)mentioning

confidence: 99%

Nicorandil repurposing in orofacial pain: preclinical findings in adult zebrafish

de Araújo,

Leite,

Vieira-Neto

et al. 2024

Preprint

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This study investigated the orofacial antinociceptive activity of nicorandil in adult zebrafish and explored the involvement of TRP channels in this effect. Nicorandil, a known antianginal drug, reduced nociceptive behaviors induced by capsaicin (TRPV1 agonist), cinnamaldehyde (TRPA1 agonist), and menthol (TRPM8 agonist) without altering the locomotor activity of the zebrafish. Pre-treatment with specific TRPA1 and TRPV1 antagonists prevented the antinociceptive effects of nicorandil, indicating its action on these channels. Molecular docking studies supported these findings, demonstrating high chemical affinity and specific binding of nicorandil to the TRPV1 and TRPA1 channels, leading to stabilization and reduced biological activity of these channels. In contrast, the antinociceptive effect of nicorandil on menthol-induced nociception was not affected by a TRPM8 antagonist, suggesting that TRPM8 modulation is not involved in nicorandil’s mechanism of action. The study highlights the potential of nicorandil as an analgesic through its interaction with TRPV1 and TRPA1 channels, providing a molecular basis for repositioning nicorandil as an effective analgesic drug.

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“…Following the treatments, animal mortality was assessed every 24 hours. After 96 hours, the number of dead sh in each group was recorded [17].…”

Section: Acute Toxicity (96 H)mentioning

confidence: 99%

Nicorandil repurposing in orofacial pain: preclinical findings in adult zebrafish

de Araújo,

Leite,

Vieira-Neto

et al. 2024

Preprint

View full text Add to dashboard Cite

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N-(2-Nitrooxyethyl)picolinamide

Abstract: In the title molecule, C8H9N3O4, the amide group is involved in the formation of an intramolecular N—H⋯N hydrogen bond. In the crystal, molecules related by translation along the a axis are linked into chains via weak intermolecular C—H⋯O interactions.

Cited by 1 publication

References 5 publications

Nicorandil repurposing in orofacial pain: preclinical findings in adult zebrafish

Nicorandil repurposing in orofacial pain: preclinical findings in adult zebrafish

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N-(2-Nitrooxyethyl)picolinamide

Abstract: In the title mol­ecule, C8H9N3O4, the amide group is involved in the formation of an intra­molecular N—H⋯N hydrogen bond. In the crystal, mol­ecules related by translation along the a axis are linked into chains via weak inter­molecular C—H⋯O inter­actions.

Cited by 1 publication

References 5 publications

Nicorandil repurposing in orofacial pain: preclinical findings in adult zebrafish

Nicorandil repurposing in orofacial pain: preclinical findings in adult zebrafish

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Product

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Abstract: In the title molecule, C8H9N3O4, the amide group is involved in the formation of an intramolecular N—H⋯N hydrogen bond. In the crystal, molecules related by translation along the a axis are linked into chains via weak intermolecular C—H⋯O interactions.