PECAM-1gene polymorphism (rs668) and subclinical markers of carotid atherosclerosis in patients with type 2 diabetes mellitus

Abstract

The platelet endothelial cell adhesion molecule 1 (PECAM-1) plays an important role in many inflammatory processes, including the development of atherosclerosis. Polymorphism rs668 of the PECAM-1 gene (373C/G) is functional, and it was reported to be associated with increased serum levels of PECAM-1. We investigated the association between the rs668 polymorphism of PECAM-1 and subclinical markers of carotid atherosclerosis in subjects with type 2 diabetes mellitus (T2DM). Five hundred and ninety-five T2DM subjects and 200 control subjects were enrolled. The carotid intima-media thickness (CIMT) and plaque characteristics (presence and structure) were assessed ultrasonographically. Biochemical analyses were performed using standard biochemical methods. Geno-typing of the PECAM-1 gene polymorphism (rs668) was performed using KASPar assays. The control examinations were performed 3.8 ± 0.5 years after the initial examination. Higher CIMT was found in patients with T2DM in comparison with subjects without T2DM. Statistically sig-nificantly faster progression of the atherosclerotic markers was shown in subjects with T2DM in comparison with the control group. When adjusted to other risk factors, the rs668 GG genotype was associated with an increased risk of carotid plaques in subjects with T2DM. We concluded that our study demonstrated a minor effect of the rs668 PECAM-1 on markers of carotid atherosclerosis in subjects with T2DM.

Association of PECAM-1 Gene Polymorphisms with Kawasaki Disease in Chinese Children

“…The PECAM-1 is an adhesion molecule that plays a vital role in vascular biology. Previous studies reported that PECAM-1 polymorphisms have been associated with coronary artery stenosis or atherosclerosis [ 23 – 25 ]. Three common polymorphisms (Leu125Val, Asn563Ser, and Gly670Arg) located on the PECAM-1 gene have been verified to be in association with these diseases [ 8 , 24 , 26 ].…”

The mitochondrial tRNAGly T10003C mutation may not be associated with diabetes mellitus

“…The etiology of T2DM is not well understood, but it is now generally believed that this disease may be related to the genetic, personal and environmental factors. Among these, genetic polymorphisms in nuclear genes have been reported to be associated with T2DM [ 2 ]. However, the maternally inherited pattern of T2DM may also be frequent [ 3 ], highlighting the importance of mitochondrial disfunction in T2DM.…”