<i>Pediococcus pentosaceus</i> PP04 improves high-fat diet-induced liver injury by the modulation of gut inflammation and intestinal microbiota in C57BL/6N mice

Wang, Yu; Tian, Yuan; Zhang, Nan; Li, Xia; Wang, Xiujuan; Wang, Weili; Zhang, Jun; Piao, Chunhong; Liu, Jingsheng

doi:10.1039/d1fo00857a

Cited by 23 publications

(29 citation statements)

References 48 publications

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“…RNA extraction and gene expression were performed as described in a previous study with minor modifications. 35,36 Briefly, the total RNA of the pancreatic tissue was extracted using a trizol reagent and the reverse transcription was performed via a first strand cDNA synthesis kit. Real-time polymerase chain reaction (RT-PCR) was conducted using SYBR FAST qPCR kit master mix universal from Kapa Biosystems according to the manufacturer's instructions, and the primer sequences are listed in Table 2.…”

Section: Methodsmentioning

confidence: 99%

Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats

Liu

Huang

et al. 2022

Food Funct.

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Section: Methodsmentioning

confidence: 99%

Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats

Liu

Huang

et al. 2022

Food Funct.

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“…Many studies have confirmed that patients with liver disease have different degrees of gut microbiota disorder, and inflammatory factors and immune cells are involved in a variety of physiological and pathological processes in the liver, which are closely related to the occurrence and development of liver disease 9–11 . Lu et al 12 detected the main gut microbiota of healthy people, asymptomatic hepatitis B virus carriers, and patients with chronic hepatitis B by 16S ribosomal ribonucleic acid (rRNA) gene sequencing technology, and found that with disease progression, the ratio of Bifidobacteriaceae and Enterobacteriaceae in the intestine gradually decreased.…”

Section: Introductionmentioning

confidence: 99%

Gut microbiota dysbiosis associated with plasma levels of Interferon‐γ and viral load in patients with acute hepatitis E infection

Bortolanza

Zhai

et al. 2021

Journal of Medical Virology

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Few studies have focused on the effect of hepatitis E virus (HEV) infection on gut microbiota. To explore the relationship between changes in gut microbiota and inflammatory factors and viral load, we conducted a comparative study of 33 patients with acute hepatitis E (AHE) patients and 25 healthy controls (HCs) using highthroughput 16S ribosomal ribonucleic acid gene sequencing. Shannon and Simpson's indices showed no significant differences in bacterial diversity between the AHE and HCs groups. Proteobacteria, Gammaproteobacteria, and Enterobacteriaceae were most abundant in the AHE group, which contributed to the difference between the gut microbiota of the AHE and HCs groups, and the same difference between the HEV-RNA-positive and HEV-RNA-negative groups. Functional prediction analysis showed that ribosome, purine metabolism, and two-component system were the top three pathways. Compared with the AHE group with normal interferon (IFN)-γ, Proteobacteria, Gammaproteobacteria, Xanthomonadaceae, and Enterobacteriaceae were more abundant in the high-IFN-γ group. The abundance of Gammaproteobacteria was positively correlated with the level of serum alanine transaminase and total bilirubin. The abundance of Gammaproteobacteria could discriminate AHE patients from HCs, and could better predict the severity of AHE patients. We believe that our findings will contribute toward a novel treatment strategy for AHE.

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“…A low abundance of gut microbiota is associated with lower efficiency in improving the inflammatory response ( 23 ). Changes in gut microbiota, loss of bacterial diversity, and changes in microbial composition have been shown to be closely associated with inflammation and oxidative stress and can be remodelled through interactions between gut microbes and dietary components ( 55 ). Many studies have shown that an HFD can reduce the richness and diversity of microbial communities and change their structure.…”

Section: Discussionmentioning

confidence: 99%

Regulatory Effect of Mung Bean Peptide on Prediabetic Mice Induced by High-Fat Diet

Tian

Zhang

et al. 2022

Front. Nutr.

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Dietary supplementation with mung bean peptides (MBPs) has several health benefits. However, the effect of MBPs on prediabetes and gut microbiota imbalance caused by a high-fat diet (HFD) has not been thoroughly studied. In this study, dietary supplementation with MBPs for 5 weeks significantly reduced HFD-induced body weight gain, hyperglycaemia, hyperlipidaemia, insulin resistance, inflammation, and oxidative stress and alleviated liver and kidney damage in mice. In addition, it significantly reversed the HFD-induced gut microbiota imbalance, increased the gut microbial diversity, and decreased the abundance of Firmicutes and Bacteroidetes in prediabetic mice. Furthermore, we identified Lachnospiraceae_NK4A136 and Lactobacillus as important eubacteria with the potential to alleviate the clinical symptoms of prediabetes. According to PICRUSt2 analysis, the changes in intestinal microflora induced by MBPs diet intervention may be related to the downregulation of expression of genes such as rocR, lysX1, and grdA and regulation of seven pathways, including pyruvate, succinic acid, and butyric acid. Moreover, 17 genera with significantly altered levels in the intestine of HFD-fed mice, including Akkermansia, Roseburia, and Ruminiclostridium, were significantly correlated with 26 important differential metabolites, such as D-glutathione, anti-oleic acid, and cucurbitacin. Overall, these results show that MBPs diet intervention plays a key role in the management of HFD-induced prediabetes.

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Pediococcus pentosaceus PP04 improves high-fat diet-induced liver injury by the modulation of gut inflammation and intestinal microbiota in C57BL/6N mice

Abstract: In this study, Pediococcus pentococcus PP04 (PP04) isolated from the Northeast pickled cabbage was given to C57BL/6N mice for eight weeks, which aimed to investigate the ameliorative effects of...

Cited by 23 publications

References 48 publications

Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats

Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats

Gut microbiota dysbiosis associated with plasma levels of Interferon‐γ and viral load in patients with acute hepatitis E infection

Regulatory Effect of Mung Bean Peptide on Prediabetic Mice Induced by High-Fat Diet

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