Post mortem validation and mechanistic study of UCB‐J in progressive supranuclear palsy patients’ brains
Miriam Scarpa,
Elisavet Vallera,
Sira Ausellé‐Bosch
et al.
Abstract:INTRODUCTIONProgressive supranuclear palsy (PSP) is a devastating 4R tauopathy affecting motor functions and is often misdiagnosed/underdiagnosed due to a lack of specific biomarkers. Synaptic loss is an eminent feature of tauopathies including PSP. Novel synaptic positron emission tomography tracer UCB‐J holds great potential for early diagnosis; however, there is a substantial knowledge gap in terms of the mechanism and the extent and nature of synaptic loss in PSP.METHODSHere, we report an in‐depth post mor… Show more
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