<i>Prevotella intermedia</i> lipopolysaccharide stimulates release of nitric oxide by inducing expression of inducible nitric oxide synthase

Kim, Sung-Jo; Ha, Mi-Suk; Choi, Eun‐Young; Choi, Jaeho; Choi, In-soon

doi:10.1111/j.1600-0765.2004.00757.x

Cited by 56 publications

(53 citation statements)

References 43 publications

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“…These ROS are associated with the microvascular complications of diabetes. It is also known that severe periodontal disease can lead to endothelial dysfunction which is an early event in atherogenesis [15][16][17][18][19]. In this study, the compounding effect of coexisting diabetes and periodontitis on the levels of oxidative stress markers was assessed.…”

Section: Discussionmentioning

confidence: 99%

Effect of Non-Surgical Therapy on Salivary Nitric Oxide and Lipid Peroxidation Levels in Type Ii Diabetic and Non Diabetic Patients With Periodontal Disease

Latha

Uppoor

Nayak

et al. 2018

Asian J Pharm Clin Res

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Objective: Reactive oxygen species have been identified as potential factors causing periodontal tissue destruction. Elevated levels of these in patients with chronic periodontitis and diabetes may aggravate the oxidative stress burden thereby accelerating the tissue damage associated with diabetes. The present study aimed to assess the effect of diabetes and periodontal disease on the oxidative stress markers and the effect of non-surgical therapy on these markers.Methods: A total of 50 participants were divided into four groups based on the selection criteria. In addition to clinical parameters and biochemical parameters (salivary nitric oxide [NO] and malondialdehyde [MDA] levels) were assessed using spectrophotometric method at baseline and 3 months after non-surgical periodontal therapy.Result: There was a statistically significant difference in the clinical parameters as well as NO and MDA levels in patients with type 2 diabetes and chronic periodontitis than other three groups at baseline and at 3 months after non-surgical periodontal therapy. Conclusion:Diabetes mellitus and periodontitis have a compounding effect on the oxidative stress. Periodontal therapy is essential for diabetic patients as it can lower the levels of oxidative damage.

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Section: Discussionmentioning

confidence: 99%

Effect of Non-Surgical Therapy on Salivary Nitric Oxide and Lipid Peroxidation Levels in Type Ii Diabetic and Non Diabetic Patients With Periodontal Disease

Latha

Uppoor

Nayak

et al. 2018

Asian J Pharm Clin Res

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“…Cytokines and other bacterial products stimulate the expression of iNOS and interfere with periodontal disease progression (5,11,12). More specifically, bacterial lipopolysaccharide stimulates NO expression in bone, as well as in other tissues (13,14). The aim of the present study was to measure salivary NO levels in individuals with chronic generalized periodontal disease, in its moderate and advanced forms, and to compare these levels with those in a group of individuals without periodontitis.…”

Section: Introductionmentioning

confidence: 99%

Nitric oxide levels in saliva increase with severity of chronic periodontitis

et al. 2007

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The aims of this study were to compare nitric oxide (NO) levels in stimulated whole saliva from individuals with and without generalized chronic periodontitis (GCP), and to evaluate correlations between these levels with a clinical diagnostic parameter. According to specific criteria, 30 individuals were divided into three groups: one comprising individuals without periodontitis (GC), a second comprising individuals with moderate GCP (GM), and a third comprising individuals with advanced GCP (GA). Samples were collected and NO levels measured. NO in the GCP group (GM: 7.78 µM; GA: 15.79 µM) was higher than in the GC group (5.86 µM). NO levels in the GA group were significantly higher (P < 0.0001) than in the GC group, and could also differentiate (P < 0.0001) the moderate and advanced forms of the disease.

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“…Small amounts of NO induced by constitutive NOS are considered beneficial, whereas excess iNOS-induced NO can mediate cell and tissue injury. Periodontal diseases are chronic inflammatory infections associated with gram-negative bacteria, including Porphyromonas gingivalis, Prevotella intermedia, and Actinobacillus actinomycetemcomitans (26), which stimulate macrophages to generate NO (1,7,16). Moreover, NO is increased in inflamed gingival tissue (11,15), and mercaptoethylguanidine, a selective iNOS inhibitor, prevents bone destruction in ligature-induced rodent periodontitis (21).…”

mentioning

confidence: 99%

Proinflammatory and Antimicrobial Nitric Oxide in Gingival Fluid of Diabetic Patients with Periodontal Disease

et al. 2006

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Abnormal nitric oxide (NO) synthesis has been implicated in the pathogenesis of both periodontal disease and diabetes mellitus. In diabetic patients, increased inducible NO synthase in inflamed gingiva correlated with NO in gingival crevicular fluid. Although increased NO reflected more-severe inflammation, it was associated with reductions in CFU of Prevotella intermedia, a major periodontopathogen, highlighting dual roles for NO.

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Prevotella intermedia lipopolysaccharide stimulates release of nitric oxide by inducing expression of inducible nitric oxide synthase

Cited by 56 publications

References 43 publications

Effect of Non-Surgical Therapy on Salivary Nitric Oxide and Lipid Peroxidation Levels in Type Ii Diabetic and Non Diabetic Patients With Periodontal Disease

Effect of Non-Surgical Therapy on Salivary Nitric Oxide and Lipid Peroxidation Levels in Type Ii Diabetic and Non Diabetic Patients With Periodontal Disease

Nitric oxide levels in saliva increase with severity of chronic periodontitis

Proinflammatory and Antimicrobial Nitric Oxide in Gingival Fluid of Diabetic Patients with Periodontal Disease

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