I₂–DMSO mediated multicomponent convergent synthesis of imidazo[2,1-a]isoquinoline derivatives via a triple in situ cross-trapping strategy

Abstract

An I2-DMSO mediated one-pot approach to imidazo[2,1-a]isoquinoline derivatives from readily available aryl methyl ketones and isoquinolin-1-amine has been demonstrated. This triple in situ cross-trapping strategy realizes the convergent integration of...

Review of application of the I2 and dimethyl sulfoxide combined reagent system to aryl methyl ketones for diverse transformations

“…Recently, based on the self-sorting reaction network model, our group developed a novel in situ triple cross-capture strategy of intermediates, realized the efficient synthesis of the imidazo[2,1- a ]isoquinoline skeleton, and constructed a new high-order reaction network model (Scheme 4A). 13 The reaction process is the convergence and integration of a self-sorting domino reaction sequence and two linear domino reaction sequences, and the construction of multiple chemical bonds is realized in one pot. At the same time, an iodine atom and a methylthio group are introduced into the target skeleton, which provide many possibilities for further modification.…”