<i>Tabellarii</i>

Meyers, Rachel

doi:10.1002/9781444338386.wbeah06313

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Table 1 Preparation Of the Pre-oxazolines1

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2023

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“…Multiple ways have been developed for the efficient construction of 2-oxazolines over the last few decades. Typical synthetic approaches for 2-oxazolines involved the cyclodehydration of β-hydroxy 23 24 or unsaturated amides 25,26 and the reaction of carboxylic acids and their esters with β-amino alcohols 27,28 followed by cyclization. Recently, microwave-assisted synthesis of chiral 2-oxazolines has been reported by treating chiral β-amino alcohols with aryl nitriles or cyano-containing compounds.…”

Section: Table 1 Preparation Of the Pre-oxazolinesmentioning

confidence: 99%

Solvent Effect on Base-Free Synthesis 4-Substituted 2-Oxazolines via Intramolecular Cyclodemesylation

Dalkılıç,

Güneş

2023

Synlett

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In this present study, the solvent effect was examined for the synthesis of 2-oxazolines via intramolecular cyclodemesylation. To determine the solvent effect, aprotic/protic polar and nonpolar solvents were screened and polar protic solvents met the best result. The remarkable feature of this synthesis is that cyclization takes place in the absence of any base or reagent, in high yields (89–96%). As a result, a series of 4-substituted chiral 2-oxazolines were successfully synthesized through a four-step process, with overall yields reaching between 79% and 88% in a greener approach.

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