ZNF208 polymorphisms associated with ischemic stroke in a southern Chinese Han population

Abstract

Some previous studies suggested telomere length was associated with the risk of ischemic stroke (IS). The aim of this study was to further confirm the association between relative telomere length (RTL) and risk of IS and to especially explore its correlation with the risk of high-risk stroke population in southern Chinese Han. RTL was determined by using real-time quantitative polymerase chain reaction from 400 ischemic stroke patients, 409 high-risk stroke populations and 399 healthy controls. The correlations between the controls and the risk of high-risk and ischemic stroke were evaluated by using an unconditional logistic regression. IS patients have shown longer RTL than controls (median1.52vs1.11, p<0.001), while the high-risk stroke populations have shorter RTL than controls (median 1.05vs1.11, p=0.027). As compared with the second tertile, the first and third tertile were associated with the elevated risks of ischemic stroke (OR=2.88, 95%CI 1.88-4.41, p<0.001; OR=6.62, 95%CI 4.32-10.15, p<0.001) after adjustment for age and gender, while no significant differences were observed in high-risk stroke populations. Further analysis stratified by age (age≤60 years and >60 years) and gender suggested that the first and second tertile of RTL were correlated with the risk of IS in each group when the second tertile was used as a reference. However, the increased risk for high-risk stroke populations were only presented in the first tertile of RTL in the age≤60 years and female groups. the RTL was associated with an increased risk of ischemic stroke, while it elevated the risk of high-risk stroke in some specific subpopulations.

Characteristics of genomic mutations and signaling pathway alterations in thymic epithelial tumors

“…Analysis further showed that the ZNF429 (36%) and ZNF208 (29%) genes had the highest frequency of mutations (Figure 2). The ZNF429 gene was reported to be significantly associated with acute postoperative pain in patients with breast cancer, while ZNF208 polymorphisms were found to be associated with ischemic stroke in a southern Chinese Han population (43,44). Research has found that PABPC1 [poly(A) binding protein cytoplasmic 1] is directly involved in the tumorigenesis of gastric cancer through its promotion of cell proliferation; consistent with this, downregulated PABPC1 expression is associated with tumor progression and a poor prognosis in colorectal cancer (45,46).…”

[Retracted] Disorder Genes Regulate the Progression of Ischemic Stroke through the NF‐κB Signaling Pathway

“…We clustered similarly expressed genes to obtain four related functional disorder modules, including the four core genes Astl, Zfp472, Fmr1, and Nap1l1. Also, other studies have shown that single-nucleotide polymorphisms (SNPs) are associated with ischemic stroke, mainly affected by ZNF208 and HNF1A [27,28]. ADAMTS-4 has an antiinflammatory effect mainly in the CNS.…”

Zinc Finger Proteins in Neuro-Related Diseases Progression

“…Studies have shown that MSUT2 knockout has anti-inflammatory and neuroprotective effects in a mouse model. The flowchart is Frankel et al, 1987;Wolfe et al, 2000;Schefe et al, 2006;Brayer et al, 2008;Town et al, 2009;Fan et al, 2012;Shi et al, 2013;Yuan et al, 2013;Xu et al, 2016;Yu et al, 2017;Brahmachari et al, 2019;Kruszka et al, 2019;Lorsch et al, 2019;Ohkubo et al, 2019;Zhang et al, 2019;Choi et al, 2020;Deshpande et al, 2020;Hu et al, 2020;Xiao et al, 2020;Dentici et shown in Figure 1. Loss of function of MSUT2 can reduce the formation of tau protein and protect the loss of neurons, but the molecular mechanism is still unclear.…”