IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs vol. 1 to 42. Supplement 7. 440 Seiten. International Agency for Research on Cancer, Lyon 1987. Preis: 65, – s.Fr

Bleyl, D. W. R.

doi:10.1002/food.19890330516

Cited by 255 publications

(4 citation statements)

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“…The International Agency for Research on Cancer (IARC) classified STC as a 2B carcinogen, which means it is possibly carcinogenic to humans, but a definitive link between human exposure and incidence of cancer has not been proven [21].…”

Section: Introductionmentioning

confidence: 99%

Effect of Sterigmatocystin or Aflatoxin Contaminated Feed on Lipid Peroxidation and Glutathione Redox System and Expression of Glutathione Redox System Regulatory Genes in Broiler Chicken

et al. 2019

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Authors studied the effect of sterigmatocystin from infected corn (STC), purified sterigmatocystin (PSTC), and aflatoxin B1 from infected corn (AFB1) on lipid peroxidation and glutathione redox parameters, including the expression of their encoding genes in a sub-chronic (14 days) trial. A total of 144 three-week-old cockerels was divided into four experimental groups (n = 36 in each). Control feed was contaminated with STC or PSTC (1590 µg STC/kg or 1570.5 µg STC/kg feed), or with AFB1 (149.1 µg AFB1/kg feed). Six birds from each group were sampled at day 1, 2, 3, 7 and 14 of mycotoxin exposure. As parameters of lipid peroxidation, conjugated dienes (CD) and trienes (CT) were measured in the liver, while malondialdehyde (MDA) concentration was determined in blood plasma, red blood cell hemolysate and liver. Reduced glutathione (GSH) concentration and glutathione peroxidase (GPx) activity were determined in the same samples, and expression of glutathione peroxidase 4 (GPX4), glutathione synthetase (GSS) and glutathione reductase (GSR) genes was measured by RT-PCR in the liver. STC, PSTC or AFB1 caused a slight, but not significant, increase in CD and CT levels; however, in the case of MDA, no increase was found in the liver. Glutathione redox system was activated in the liver by AFB1, but less markedly by STC/PSTC. PSTC and AFB1 resulted in a higher expression of GPX4, while GSS expression was down-regulated by AFB1 on day 1, but up-regulated by STC on day 2 and by both mycotoxins on day 7. However, on day 14, GSS expression was down-regulated by PSTC. Expression of GSR was low on day 1 in AFB1 and PSTC groups, but later it was up-regulated by AFB1. The observed changes regarding gene expression strengthen the hypothesis that the mild oxidative stress, caused by the applied STC doses, activates the glutathione redox system of broiler chickens.

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Section: Introductionmentioning

confidence: 99%

Effect of Sterigmatocystin or Aflatoxin Contaminated Feed on Lipid Peroxidation and Glutathione Redox System and Expression of Glutathione Redox System Regulatory Genes in Broiler Chicken

et al. 2019

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“…Similarly, the enhancement of cell survival through the HGFR/PI3K/Akt pathway could offer a mechanistic explanation for OTA's well-known effect in experimental animals, specifically kidney tumors in rats and mice in a sex-dependent manner. [16,100,101] It is important to note that this postulation is supported by evidence from human kidney cells rather than ani- 2015). [26] In this study, the effects of OTA on cell signaling pathways were investigated using HK-2 cell lines under different experimental conditions: i) OTA exposure increased cell death, as well as Akt and ERK activation.…”

Section: Hgfr and Ochratoxin Amentioning

confidence: 96%

Membrane Receptor‐Mediated Disruption of Cellular Homeostasis: Changes in Intracellular Signaling Pathways Increase the Toxicity of Ochratoxin A

Aydemir,

Yaman,

Kilic

2024

Molecular Nutrition Food Res

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Organisms maintain their cellular homeostatic balance by interacting with their environment through the use of their cell surface receptors. Membrane based receptors such as the transforming growth factor β receptor (TGFR), the prolactin receptor (PRLR), and hepatocyte growth factor receptor (HGFR), along with their associated signaling cascade, play significant roles in retaining cellular homeostasis. While these receptors and related signaling pathways are essential for health of cell and organism, their dysregulation can lead to imbalance in cell function with severe pathological conditions such as cell death or cancer. Ochratoxin A (OTA) can disrupt cellular homeostasis by altering expression levels of these receptors and/or receptor‐associated intracellular downstream signaling modulators and/or pattern and levels of their phosphorylation/dephosphorylation. Recent studies have shown that the activity of the TGFR, the PRLR, and HGFR and their associated signaling cascades change upon OTA exposure. A critical evaluation of these findings suggests that while increased activity of the HGFR and TGFR signaling pathways leads to an increase in cell survival and fibrosis, decreased activity of the PRLR signaling pathway leads to tissue damage. This review explores the roles of these receptors in OTA‐related pathologies and effects on cellular homeostasis.

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Section: ■ Introductionmentioning

confidence: 99%

“…Benzene is one of the ubiquitous environmental pollutants and has been classified as a group I carcinogen by International Agency for Research on Cancer (IARC) and U.S. Environmental Protection Agency (EPA). , Long-term environmental and occupational exposure to benzene could increase the risk of disease such as anemia, pancytopenia, aplasia, acute myeloid leukemia, and so on. − Once exposed, benzene undergoes a complex metabolism pathway in the human body, converting benzene to certain metabolites . The American Conference of Governmental Industrial Hygienists (ACGIH) suggests that trans , trans -muconic acid ( tt -MA) as a biological exposure index (BEI) is suitable urinary biomarker of benzene at high concentrations (above 1 ppm). − Various test facilities have been applied to the determination of urinary tt -MA including gas chromatography (GC), high-performance liquid chromatography (HPLC), ultraviolet and visible spectrophotometry (UV–vis), and mass spectrometry (MS) detection. − However, there are many difficulties in these techniques which are described with expensive instruments and raw stocks, complicated pretreatment, limited selectivity, and so on.…”

Section: Introductionmentioning

confidence: 99%

Ln(III)-Functionalized Metal–Organic Frameworks Hybrid System: Luminescence Properties and Sensor for trans,trans-Muconic Acid as a Biomarker of Benzene

Yan

2018

Inorg. Chem.

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By application of a straightforward postsynthetic modification strategy, a luminescent lanthanide-based MOFs hybrid material, Tb(III)@MOF-SO, is first fabricated by loading Tb(III) ions into the pores of Zn-based MOF-SO. This hybrid system is constructed on notable and specific luminous sensitization of MOF-SO to Tb(III) ions. The further study shows that bi-metal-loaded Eu(III)/Tb(III)@MOF-SO exhibits a Tb(III)-induced luminescence of Eu(III) ions, and the emissions of it all fall in the white region by altering the ratio of Eu(III)/Tb(III) ions and the excitation wavelengths. A kind of white-lighting thin film based on Eu(III)/Tb(III)@MOF-SO exhibits dazzling white light when excited at 295 nm ( X = 0.338, Y = 0.323). Furthermore, the Tb(III)@MOF-SO is first developed as a fluorescence sensor specifically toward biomarker of benzene, trans, trans-muconic acid ( tt-MA), based on fluorescence quenching. This reusable sensor with high water tolerance and photostability displays excellent selectivity and sensitivity with a detection limit as low as 0.1 ppm, while being provided with the high antijamming of other urinary chemicals. These results make the sensor has the potential for the practical detection of tt-MA in a urine system. The possible quenching mechanisms are also investigated in detail.

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IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs vol. 1 to 42. Supplement 7. 440 Seiten. International Agency for Research on Cancer, Lyon 1987. Preis: 65, – s.Fr

Cited by 255 publications

References 0 publications

Effect of Sterigmatocystin or Aflatoxin Contaminated Feed on Lipid Peroxidation and Glutathione Redox System and Expression of Glutathione Redox System Regulatory Genes in Broiler Chicken

Effect of Sterigmatocystin or Aflatoxin Contaminated Feed on Lipid Peroxidation and Glutathione Redox System and Expression of Glutathione Redox System Regulatory Genes in Broiler Chicken

Membrane Receptor‐Mediated Disruption of Cellular Homeostasis: Changes in Intracellular Signaling Pathways Increase the Toxicity of Ochratoxin A

Ln(III)-Functionalized Metal–Organic Frameworks Hybrid System: Luminescence Properties and Sensor for trans,trans-Muconic Acid as a Biomarker of Benzene

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