Ibuprofen analysis in blood samples by palladium particles-impregnated sodium montmorillonite electrodes: Validation using high performance liquid chromatography

Loudiki, A.; Boumya, W.; Hammani, H.; Nasrellah, Hamid; Bouabi, Y. El; Zeroual, M.; Farahi, A.; Lahrich, S.; Hnini, Khadija; Achak, M.; Bakasse, M.; Mhammedi, M.A. El

doi:10.1016/j.msec.2016.07.024

Cited by 15 publications

(7 citation statements)

References 36 publications

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“…The electrochemical behavior of drugs has been studied using cyclic voltammetry, chronocoulometry, electrochemical impedance spectroscopy and differential pulse voltammetry. [33][34][35][36] Electrochemical measurements are generally carried out in a medium consisting of an electrolyte support, the choice of which is mainly dictated by the solubility of the analyte and its redox activity, such as electrical conductivity, electrochemical activity and chemical reactivity. For this purpose, the carrier electrolyte must not react with the analyte (or products) and must not undergo electrochemical reactions.…”

Section: Electrochemical Determination Of Hydroxychloroquinementioning

confidence: 99%

“…The application of electrochemical techniques in the analysis of drugs and pharmaceutical products either in biological medium has increased considerably in recent years (Table 1). [33–68] The renewed interest in electrochemical techniques can be attributed in part to more sophisticated instrumentation and increased understanding of the technique themselves. The application of different electrochemical modes in the analysis of drugs and pharmaceuticals are available for the quantification of drugs.…”

Section: Introductionmentioning

confidence: 99%

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Current Trends in Analytical Methods for the Determination of Hydroxychloroquine and Its Application as Treatment for COVID‐19

et al. 2020

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Hydroxychloroquine (HCQ) is a drug indicated in rheumatology for the treatment of rheumatoid arthritis and systemic lupus erythematosus for its anti‐inflammatory and immunomodulatory properties. Many countries such as Morocco have recommended the use of HCQ for the treatment of COVID‐19 infection. This medication is responsible for severe acute poisoning. Therefore, Hospital laboratories have a fundamental role in affirming the diagnosis and assessing the severity of intoxication by measuring HCQ, carried out in the urine and preferably in whole blood. The analytical techniques used are essentially chromatographic. Unfortunately, these reference methods for forensic analyzes are difficult to adapt to emergency due to their delay in reporting results.

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Section: Electrochemical Determination Of Hydroxychloroquinementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Current Trends in Analytical Methods for the Determination of Hydroxychloroquine and Its Application as Treatment for COVID‐19

et al. 2020

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“…There are many published methods regarding ibuprofen chiral resolution, mainly made by chromatographic methods [3][4][5][6][7][8][9][10][11] and few by capillary electrophoresis [12][13][14][15][16]. In general, the methods are designed to analyze enantiomers in biological environment for different purposes such as enantiomers conversion, differences regarding their biological behavior etc.…”

Section: Introductionmentioning

confidence: 99%

Research Article. The Influence of Some Parameters on Chiral Separation of Ibuprofen by High-Performance Liquid Chromatography and Capillary Electrophoresis

Balint

Cârje

Muntean

et al. 2017

Acta Medica Marisiensis

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Objective: The aim of the study was to compare the influence of mobile phase composition and temperature on chiral separation of racemic ibuprofen by capillary electrophoresis and high performance liquid chromatography with UV detection. Materials and methods: Racemic ibuprofen was analysed on a chiral OVM column with an HPLC system 1100 Agilent Technologies, under isocratic elution, by using potassium dihydrogen phosphate 20 mM and ethanol in mobile phase. The flow rate was set at 1 mL/min, UV detector at 220 nm and different column temperatures were tested. For electrophoresis separation an Agilent CE G1600AX Capillary Electrophoresis System system, with UV detection, was used. The electrophoresis analysis was performed at different pH values and temperatures, with phosphate buffer 25 mM and methyl-β-cyclodextrin as chiral selector. Results: The chromatograhic analysis reveals a high influence of mobile phase pH on ibuprofen enantiomers separation. An elution with a mixture of potassium dihydrogen phosphate 20 mM pH=3 and ethanol, at 25ºC, allowed enantiomers separation with good resolution in less than 8 min. Conclusions: The proposed HPLC method proved suitable for the separation of ibuprofen enantiomers with a good resolution, but the capillary electrophoresis tested parameters did not allow chiral discrimination.

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“…These different characteristics have attracted attention in the electrochemistry and electroanalytical fields, and show a growth in these fields. Employment of modified electrodes, specifically clays, as proposed in the present study, is a field in constant development, and increasingly new methods of preparation are reported in literature for various matrices [21,[27][28][29][30][31][32][33]. Several studies showed the application of modified electrodes for metal ion determination in aqueous solutions, some of them employing a modification process with clays and organoclays [34][35][36][37][38][39][40][41].…”

Section: Introductionmentioning

confidence: 99%

Thermal and electrochemical studies of Cu(II) 8-hydroxyquinoline organophilic montmorillonite

Lupi

Franzin

Pereira

et al. 2017

J Therm Anal Calorim

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The thermal and electrochemical behavior of montmorillonite clay-8-hydroxyquinoline (8-HQ) film was studied in the absence and presence of aqueous Cu(II) ions. The suggested formation of the ternary complex type: {Pt/ [[ Si-O] n [Cu(II)(OH 2) n (8-HQ) k ]} 3-n-k , with thermal stability up to 350°C, was studied, based on UV-spectroscopy, thermal (DTG-DSC, molecular fluorescence and XRD. The Pt/binary composite film (SWy-1:8-HQ) interphase composed of montmorillonite (SWy-1) with 8-hydroxyquinoline (8-HQ) was investigated by electrochemical techniques analyzing the cyclic voltammograms (CVs) obtained at different scan rates (v) and copper(II) ion concentrations. The mechanical stability of the thin films was demonstrated by performing 80 successive voltammetric cycles. Two pairs of redox peaks, indicated by peaks A/D and C/B were observed. For Cu(II) ions in solution, the log i p 9 log v relationships showed processes controlled by adsorption, peaks A/D, and by diffusion, peaks C/B. The analysis of i p / v 1/2 and i pa /i pc versus v suggested two homogeneous coupled reactions, being both reversible and fast kinetic chemical reactions, associated to the mechanisms chemical-electrochemical (CE) and electrochemical-chemical (EC), respectively. The modified electrode showed a good sensitivity to low concentrations of Cu(II) ions, which opens the possibility of being used in chemical analysis. Keywords Organic montmorillonite composites Á TG-DTA simultaneous, Cu(II) ions Á Reversible coupled reactions Á Cu(I)/Cu(II) redox species Electronic supplementary material The online version of this article (

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Ibuprofen analysis in blood samples by palladium particles-impregnated sodium montmorillonite electrodes: Validation using high performance liquid chromatography

Cited by 15 publications

References 36 publications

Current Trends in Analytical Methods for the Determination of Hydroxychloroquine and Its Application as Treatment for COVID‐19

Current Trends in Analytical Methods for the Determination of Hydroxychloroquine and Its Application as Treatment for COVID‐19

Research Article. The Influence of Some Parameters on Chiral Separation of Ibuprofen by High-Performance Liquid Chromatography and Capillary Electrophoresis

Thermal and electrochemical studies of Cu(II) 8-hydroxyquinoline organophilic montmorillonite

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