Ibuprofen sorption and release by modified natural zeolites as prospective drug carriers

Abstract

The sorption of ibuprofen by modified natural zeolite composites at three concentration levels (10, 20 and 30 mmol/100 g) of cationic surfactants – benzalkonium chloride and cetylpyridinium chloride, in a buffer solution (pH 7.4), was studied. Characterization of the composites before and after ibuprofen sorption was performed by drug sorption and isotherm studies, zeta potential and Fourier Transform infrared spectroscopic analysis. The biopharmaceutical performance of cationic surfactant-modified zeolites as drug formulation excipients was evaluated by in vitro dissolution experiments from the composites with medium surfactant contents. The drug sorption was influenced by the surfactant type and amount used for the zeolite modification. Prolonged drug release over a period of 8 h (up to ~40%) was achieved with both groups of samples. The kinetic analysis showed that the drug release profiles were best fitted with the Higuchi and the Bhaskar models, indicating a combination of drug diffusion and ion exchange as the predominant release mechanisms.

Natural zeolite for adsorbing and release of functional materials

“…Particularly, CZ was used as hosts for aspirin, doxorubicin, and paraquat molecules, [22][23][24] as transporter for controlled ibuprofen and anthelminthics delivery and release. 25 A distinctive feature for drug delivery is the CZ mesoporosity 9 that allows to adsorb and transport simultaneously several types of molecules, nanoparticles, and large biomolecules for different biomedical applications. In addition, simple modification of CZ allows a controlled change of micropore sizes and specific surface area without deformation of the CZ skeleton.…”

Photodynamic dye adsorption and release performance of natural zeolite

“…Numerous examples of ZLs application in drug delivery and wound treatment have been reported in the literature 32 33 34 35 36 37 38 39 . Very important feature of zeolites for drug delivery is their mesoporosity 40 that allows to combine diffusional pathways on different size scales and adsorb different molecules, nanoparticles and large biomolecules.…”

“…Specifically, natural and sensitized ZLs have been used as hosts for small drug compounds, such as aspirin, doxorubicin, and paraquat molecules 32 33 34 35 36 . Furthermore, the loading, controlled delivery and release of anthelminthics and ibuprofen have been successfully demonstrated 37 . Clinoptilolite type of natural zeolite is safe for human.…”

Functionalization of halloysite nanotubes by enlargement and hydrophobicity for sustained release of analgesic

“…Tubular nanomaterials, which own good biocompatibility, high specific surface areas, and unique nanoscale matrix for the assembly of organic components, are considered as ideal excipients and substances [8,9]. Carbon nanotubes (CNTs) were also investigated as potential delivery vehicles of nucleic acids, proteins and drug molecules, as well as ceramic nanotubes, including SiO 2 , TiO 2 , ZrO 2 , CeO 2 , and ZnCr 2 O 4 [10][11][12]. However, toxicity concerns and high cost make these materials less attractive for large-scale applications [13,14].…”