ICAM1 promotes bone metastasis via integrin‐mediated TGF‐β/EMT signaling in triple‐negative breast cancer

Chen, Mingcang; Wu, Chun-Yu; Fu, Zhengwei; Liu, Sheng

doi:10.1111/cas.15532

Cited by 25 publications

(9 citation statements)

References 60 publications

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“…In triple negative breast cancer (TNBC), the ICAM1 antibody significantly reduced cell migration and ICAM1 could act as a molecular target for TNBC [ 23 ]. A recent study reported that ICAM1 bound with integrins to activate the epithelial-to-mesenchymal transition process through TGF-β/SMAD signaling, ultimately enhancing breast cancer cell invasion [ 65 ]. Consistent with previous studies, our study found that ICAM1 could promote breast cancer cells local invasion.…”

Section: Discussionmentioning

confidence: 99%

Water channel protein AQP1 in cytoplasm is a critical factor in breast cancer local invasion

Guo

Zhang

Liu

et al. 2023

J Exp Clin Cancer Res

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Background Metastasis of breast cancer grows from the local invasion to the distant colonization. Blocking the local invasion step would be promising for breast cancer treatment. Our present study demonstrated AQP1 was a crucial target in breast cancer local invasion. Methods Mass spectrometry combined with bioinformatics analysis was used to identify AQP1 associated proteins ANXA2 and Rab1b. Co-immunoprecipitation, immunofluorescence assays and cell functional experiments were carried out to define the relationship among AQP1, ANXA2 and Rab1b and their re-localization in breast cancer cells. The Cox proportional hazards regression model was performed toward the identification of relevant prognostic factors. Survival curves were plotted by the Kaplan–Meier method and compared by the log-rank test. Results Here, we show that the cytoplasmic water channel protein AQP1, a crucial target in breast cancer local invasion, recruited ANXA2 from the cellular membrane to the Golgi apparatus, promoted Golgi apparatus extension, and induced breast cancer cell migration and invasion. In addition, cytoplasmic AQP1 recruited cytosolic free Rab1b to the Golgi apparatus to form a ternary complex containing AQP1, ANXA2, and Rab1b, which induced cellular secretion of the pro-metastatic proteins ICAM1 and CTSS. Cellular secretion of ICAM1 and CTSS led to the migration and invasion of breast cancer cells. Both in vivo assay and clinical analysis data confirmed above results. Conclusions Our findings suggested a novel mechanism for AQP1-induced breast cancer local invasion. Therefore, targeting AQP1 offers promises in breast cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Water channel protein AQP1 in cytoplasm is a critical factor in breast cancer local invasion

Guo

Zhang

Liu

et al. 2023

J Exp Clin Cancer Res

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show abstract

“…Reprogramming processes, such as EMT, also play an important role. For example, Chen et al found that after interacting with integrins, intercellular adhesion molecule 1 caused tumor cells to undergo EMT via TGF-β/SMAD signaling, after which the cells’ mesenchymal properties facilitated tumor cell metastasis through blood circulation [85] . Furthermore, because BC cells’ exosomes disrupt bone remodeling in the BM process, they may effectively serve as drug carriers for treating MBCB [86] , [87] .…”

Section: Discussionmentioning

confidence: 99%

How has the field of metastatic breast cancer in bones evolved over the past 22 years?

Chen¹,

Guo²,

He³

et al. 2023

Journal of Bone Oncology

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“…Intercellular adhesion molecule 1 (ICAM1) is an important regulator of tumorigenesis and metastasis. Multiple integrin receptors (integrin α 2 , α L , α M , α V , β 2 , β 6 ) were shown to mediate the process by which ICAM1 promotes bone metastasis in breast cancer through TGF-β/SMAD/epithelial-to-mesenchymal transition signaling [ 131 ].…”

Section: Integrins Are Participants and Therapeutic Targets In Bone M...mentioning

confidence: 99%

The role of integrin family in bone metabolism and tumor bone metastasis

Mao

Wang

et al. 2023

Cell Death Discov.

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Integrins have been the research focus of cell-extracellular matrix adhesion (ECM) and cytokine receptor signal transduction. They are involved in the regulation of bone metabolism of bone precursor cells, mesenchymal stem cells (MSCs), osteoblasts (OBs), osteoclasts (OCs), and osteocytes. Recent studies expanded and updated the role of integrin in bone metabolism, and a large number of novel cytokines were found to activate bone metabolism pathways through interaction with integrin receptors. Integrins act as transducers that mediate the regulation of bone-related cells by mechanical stress, fluid shear stress (FSS), microgravity, hypergravity, extracellular pressure, and a variety of physical factors. Integrins mediate bone metastasis of breast, prostate, and lung cancer by promoting cancer cell adhesion, migration, and survival. Integrin-mediated targeted therapy showed promising prospects in bone metabolic diseases. This review emphasizes the latest research results of integrins in bone metabolism and bone metastasis and provides a vision for treatment strategies.

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ICAM1 promotes bone metastasis via integrin‐mediated TGF‐β/EMT signaling in triple‐negative breast cancer

Cited by 25 publications

References 60 publications

Water channel protein AQP1 in cytoplasm is a critical factor in breast cancer local invasion

Water channel protein AQP1 in cytoplasm is a critical factor in breast cancer local invasion

How has the field of metastatic breast cancer in bones evolved over the past 22 years?

The role of integrin family in bone metabolism and tumor bone metastasis

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