2020
DOI: 10.1016/j.lfs.2020.117847
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Icariin protects neurons from endoplasmic reticulum stress-induced apoptosis after OGD/R injury via suppressing IRE1α-XBP1 signaling pathway

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Cited by 41 publications
(30 citation statements)
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“…Recently, it has been reported that IRE1, which is the most conserved ER stress sensor, and the expression of X-box binding protein-1 (XBP1) and GRP78/Bip markedly increased in the striatum and cortex of injured brain regions after ischemic stroke [9,10]. In addition, research shows that a avonol glycoside, icariin, suppresses IRE1-XBP1 signaling to protect neurons from ER stress-induced apoptosis after oxygen-glucose deprivation/re-oxygenation injury [11].…”
Section: Introductionmentioning
confidence: 99%
“…Recently, it has been reported that IRE1, which is the most conserved ER stress sensor, and the expression of X-box binding protein-1 (XBP1) and GRP78/Bip markedly increased in the striatum and cortex of injured brain regions after ischemic stroke [9,10]. In addition, research shows that a avonol glycoside, icariin, suppresses IRE1-XBP1 signaling to protect neurons from ER stress-induced apoptosis after oxygen-glucose deprivation/re-oxygenation injury [11].…”
Section: Introductionmentioning
confidence: 99%
“…IL-1 β, IL-6, TNF-α, TGF-β1, NF-κB p65, PPARα, PPARγ, IκB-α, IRE1α, XBP1u, XBP1s, caspase-3, Bcl-2, bax (Deng et al, 2016;Xiong et al, 2016;Mo et al, 2020;Yang et al, 2020) Quercetin 5-25 mg/kg (in vivo), 10 μM (in vitro)…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, Icariin suppressed inhibitory κB (IκB)-α degradation and NF-κB activation and up-regulated peroxisome proliferator-activated receptor α (PPARα) and peroxisome proliferator activated receptor γ (PPARγ) levels in I/R model (Deng et al, 2016;Xiong et al, 2016). Moreover, a study by Mo et al found that Icariin can inhibit apoptosis and inflammatory in neurons after OGD/R through inositol requiring enzyme 1 (IRE1)-X-Box Binding Protein 1 (XBP1) signaling pathway (Mo et al, 2020).…”
Section: Icariinmentioning
confidence: 99%
“…Elevated proinflammatory cytokines aggregate a large number of inflammatory cells which secrete excessive inflammatory cytokines and aggravate brain damage [ 39 ]. Mo et al found that OGD/R induced the expression of IL-1 β , IL-6, and TNF- α in the supernatant of microglia [ 40 ]. In the results of Zhang et al, inflammatory factors, such as TNF- α , IL-1 β , IL-6, iNOS, CD32, and CD68, were markedly upregulated in the ischemic striatum at 24 h after reperfusion in mice following MCAO [ 41 ].…”
Section: Discussionmentioning
confidence: 99%