ICG-loaded gold nano-bipyramids with NIR activatable dual PTT-PDT therapeutic potential in melanoma cells

Campu, Andreea; Focșan, Monica; Lerouge, Frédéric; Borlan, Raluca; Tie, Leopold; Rugină, Dumitriţa; Aştilean, Simion

doi:10.1016/j.colsurfb.2020.111213

Cited by 64 publications

(45 citation statements)

References 54 publications

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“…The PS reacts with 3 O 2 through energy transfer as the PS returns to the ground level and 1 O 2 is produced (Equation (6)), a strong cytotoxic agent in the PDT of cancers [ 40 ]. Hence, PDT efficiency depends on the yield of 1 O 2 generation but also on the nano-system ability to target the endorsed biological layer (for example, cancer cells) [ 4 ].

…”

Section: Resultsmentioning

confidence: 99%

“…At present, researchers make use of nanotechnology in medical applications to develop nanoparticles (NPs) able to deliver contrast agents and other substances of interest to tumor sites and, at the same time, tailored to fight cancer through different types of therapy [ 2 , 3 ]. For example, gold NPs have been developed together with indocyanine green in order to achieve a hybrid nano-system to perform both photodynamic and photothermal therapy for an innovative targeted and efficient therapeutic strategy [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Anna Oniszczuk et al [ 13 ] claims that the most appropriate irradiation for the human body is with light that has a wavelength of 630 nm or above. However, despite the fact that the Food and Drug Administration has approved many fluorophores for medical use with emission properties in the ultraviolet and visible region of the electromagnetic spectrum, only two emit light in the NIR domain (650–900 nm), namely indocyanine green and methylene blue [ 4 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Fluorescent Phthalocyanine-Encapsulated Bovine Serum Albumin Nanoparticles: Their Deployment as Therapeutic Agents in the NIR Region

et al. 2021

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In recent times, researchers have aimed for new strategies to combat cancer by the implementation of nanotechnologies in biomedical applications. This work focuses on developing protein-based nanoparticles loaded with a newly synthesized NIR emitting and absorbing phthalocyanine dye, with photodynamic and photothermal properties. More precisely, we synthesized highly reproducible bovine serum albumin-based nanoparticles (75% particle yield) through a two-step protocol and successfully encapsulated the NIR active photosensitizer agent, achieving a good loading efficiency of 91%. Making use of molecular docking simulations, we confirm that the NIR photosensitizer is well protected within the nanoparticles, docked in site I of the albumin molecule. Encouraging results were obtained for our nanoparticles towards biomedical use, thanks to their negatively charged surface (−13.6 ± 0.5 mV) and hydrodynamic diameter (25.06 ± 0.62 nm), favorable for benefitting from the enhanced permeability and retention effect; moreover, the MTT viability assay upholds the good biocompatibility of our NIR active nanoparticles. Finally, upon irradiation with an NIR 785 nm laser, the dual phototherapeutic effect of our NIR fluorescent nanoparticles was highlighted by their excellent light-to-heat conversion performance (photothermal conversion efficiency 20%) and good photothermal and size stability, supporting their further implementation as fluorescent therapeutic agents in biomedical applications.

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…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fluorescent Phthalocyanine-Encapsulated Bovine Serum Albumin Nanoparticles: Their Deployment as Therapeutic Agents in the NIR Region

et al. 2021

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“…Inorganic–inorganic nanohybrids include metals, alloys, and composite-based nanohybrids for photo-therapy. 138,139 A main focus will be on recent developments within the last 5 years. Gold and iron metal-based nanohybrids have already been well explored in this field.…”

Section: Inorganic–inorganic Nanohybrids For Photothermal and Photodynamic Therapies With Imaging Propertiesmentioning

confidence: 99%

Inorganic–inorganic nanohybrids for drug delivery, imaging and photo-therapy: recent developments and future scope

et al. 2021

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“…5,12 Until today, while fluorophores with emission in a wide range of the electromagnetic spectrum have been approved by the Food and Drug Administration (FDA) for medical purpose, only two emit light in the NIR region 650-900 nm, namely Indocyanine Green (ICG) and Methylene Blue (MB). 13,14 Unlike classic small-molecule fluorophores, via the process of restriction of intramolecular motion, aggregation-induced emission luminogens can emit bright NIR light in aggregated states. 15,16 Thanks to their strong NIR fluorescence and good photobleaching resistance, aggregation-induced emission luminogens recently attained great interest in biomedical applications.…”

Section: Near-infrared Dyes Selected For Fluorescence Imagingmentioning

confidence: 99%

Interventional NIR Fluorescence Imaging of Cancer: Review on Next Generation of Dye-Loaded Protein-Based Nanoparticles for Real-Time Feedback During Cancer Surgery

Borlan

Focșan

Maniu

et al. 2021

IJN

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The use of fluorescence imaging technique for visualization, resection and treatment of cancerous tissue, attained plenty of interest once the promise of whole body and deep tissue near-infrared (NIR) imaging emerged. Why is NIR so desired? Contrast agents with optical properties in the NIR spectral range offer an upgrade for the diagnosis and treatment of cancer, by dint of the deep tissue penetration of light in the NIR region of the electromagnetic spectrum, also known as the optical window in biological tissue. Thus, the development of a new generation of NIR emitting and absorbing contrast agents able to overcome the shortcomings of the basic free dye administration is absolutely essential. Several examples of nanoparticles (NPs) have been successfully implemented as carriers for NIR dye molecules to the tumour site owing to their prolonged blood circulation time and enhanced accumulation within the tumour, as well as their increased fluorescence signal relative to free fluorophore emission and active targeting of cancerous cells. Due to their versatile structure, good biocompatibility and capability to efficiently load dyes and bioconjugate with diverse cancer-targeting ligands, the research area of developing protein-based NPs encapsulated or conjugated with NIR dyes is highly promising but still in its infancy. The current review aims to provide an up-to-date overview on the biocompatibility, specific targeting and versatility offered by protein-based NPs loaded with different classes of NIR dyes as next-generation fluorescent agents. Moreover, this study brings to light the newest and most relevant advances involving the state-of-the-art NIR fluorescent agents for the real-time interventional NIR fluorescence imaging of cancer in clinical trials.

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ICG-loaded gold nano-bipyramids with NIR activatable dual PTT-PDT therapeutic potential in melanoma cells

Cited by 64 publications

References 54 publications

Fluorescent Phthalocyanine-Encapsulated Bovine Serum Albumin Nanoparticles: Their Deployment as Therapeutic Agents in the NIR Region

Fluorescent Phthalocyanine-Encapsulated Bovine Serum Albumin Nanoparticles: Their Deployment as Therapeutic Agents in the NIR Region

Inorganic–inorganic nanohybrids for drug delivery, imaging and photo-therapy: recent developments and future scope

Interventional NIR Fluorescence Imaging of Cancer: Review on Next Generation of Dye-Loaded Protein-Based Nanoparticles for Real-Time Feedback During Cancer Surgery

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