2009
DOI: 10.1016/j.bpj.2008.12.1110
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Identification And Characterization Of Cardiac Troponin I From The Trout Heart

Abstract: Skeletal tropomyosin, (Tm), is an a-helical coiled-coil which binds to actin, and with troponin, regulates muscle contraction. We previously demonstrated that a conserved Asp 137 in the hydrophobic interface produces a dynamic region in the middle of Tm, and that this region is involved in the myosin dependent activation of the thin filament at high Ca 2þ , (Sumida et. al. JBC 283 2008). The current work characterizes a long-range interaction between positions 137 and 190. The thermodynamic properties of wild … Show more

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