Abstract:Skeletal tropomyosin, (Tm), is an a-helical coiled-coil which binds to actin, and with troponin, regulates muscle contraction. We previously demonstrated that a conserved Asp 137 in the hydrophobic interface produces a dynamic region in the middle of Tm, and that this region is involved in the myosin dependent activation of the thin filament at high Ca 2þ , (Sumida et. al. JBC 283 2008). The current work characterizes a long-range interaction between positions 137 and 190. The thermodynamic properties of wild … Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.