Identification and ecdysteroid antagonist activity of three oligostilbenes from the seeds of Carex pendula (Cyperaceae)

Meng, Yanhui; Bourne, Pauline; Whiting, Pensri; Šik, Vladimír; Dinan, Laurence

doi:10.1016/s0031-9422(01)00061-9

Cited by 33 publications

(17 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oligostilbenes are bioactive natural products contained in the families Vitaceae, Cyperaceae, and Leguiminosae, as well as other medicinal plants [1,2]. However, the genus of Vitis contains a great diversity of oligostilbenes which are biogenetically synthesized by oxidative coupling of resveratrol or (+)--viniferin [3].…”

Section: Introductionmentioning

confidence: 99%

Preparative separation of oligostilbenes from Vitis thunbergii var. taiwaniana by centrifugal partition chromatography followed by Sephadex LH-20 column chromatography

Chen

Wang

2009

Separation and Purification Technology

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Preparative separation of oligostilbenes from Vitis thunbergii var. taiwaniana by centrifugal partition chromatography followed by Sephadex LH-20 column chromatography

Chen

Wang

2009

Separation and Purification Technology

View full text Add to dashboard Cite

“…Miyabenol C is a resveratrol trimer and has been found in plants including various Vitis species [ 39 , 40 ], Caragana species [ 41 – 44 ], Carex species [ 45 , 46 ], Parthenocissus quinquefolia [ 47 ], and Sophora davidii [ 48 ]. Previous studies have shown that miyabenol C possesses various functions, such as being anti-proliferative and pro-apoptotic in tumor cells [ 45 , 49 ], inhibiting the activity of protein kinas C [ 44 , 50 ], antagonizing human 5-hydroxytryptamine (5-HT) receptor [ 51 ], having estrogenic activity through binding to estrogen receptor [ 52 , 53 ], and having ecdysteroid antagonistic activity in Drosophila cell bioassays [ 46 ]. However, information on the role of miyabenol C in AD is scarce, with only one recent study showing that miyabenol C has marginal effect on inhibiting Aβ fibril formation [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

The Resveratrol Trimer Miyabenol C Inhibits β-Secretase Activity and β-Amyloid Generation

et al. 2015

View full text Add to dashboard Cite

Accumulation and deposition of amyloid-β peptide (Aβ) in the brain is a primary cause of the pathogenesis of Alzheimer’s disease (AD). Aβ is generated from amyloid-β precursor protein (APP) through sequential cleavages first by β-secretase and then by γ-secretase. Inhibiting β-secretase activity is believed to be one of the most promising strategies for AD treatment. In the present study, we found that a resveratrol trimer, miyabenol C, isolated from stems and leaves of the small-leaf grape (Vitisthunbergii var. taiwaniana), can markedly reduce Aβ and sAPPβ levels in both cell cultures and the brain of AD model mice. Mechanistic studies revealed that miyabenol C affects neither protein levels of APP, the two major α-secretases ADAM10 and TACE, and the γ-secretase component Presenilin 1, nor γ-secretase-mediated Notch processing and TACE activity. In contrast, although miyabenol C has no effect on altering protein levels of the β-secretase BACE1, it can inhibit both in vitro and in vivo β-secretase activity. Together, our results indicate that miyabenol C is a prominent β-secretase inhibitor and lead compound for AD drug development.

show abstract

“…Cyperus longus and Cyperus rotundus are also remarkable sources of stilbenes, from which 10 (1, 5, 31-37, 40) and 13 (2, 31, 32, 37, 48-56) compounds were isolated, respectively. The isolated stilbenes seem to be stable, only in cases of cis-miyabenol A (64) and cis-miyabenol C (43) was mentioned that if they are exposed to light, they isomerize to the trans-isomers [30]. Around 45% of stilbenes reported from sedges are monomers (Figure 1).…”

Section: Stilbenes Isolated From Cyperaceae Speciesmentioning

confidence: 99%

Chemistry and Pharmacology of Cyperaceae Stilbenoids: A Review

2021

View full text Add to dashboard Cite

Cyperaceae is a cosmopolitan plant family with approx. 5000 species distributed worldwide. Several members of this family are used in traditional medicines for the treatment of different diseases. In the last few decades, constituents with great chemical diversity were isolated from sedges, and a wide range of biological activities were detected either for crude extracts or for pure compounds. Among the isolated compounds, phenolic derivatives are the most important, especially stilbenoids, and flavonoids. To date, more than 60 stilbenoids were isolated from 28 Cyperaceae species. Pharmacological investigation of Cyperaceae stilbenoids revealed that several compounds possess promising activities; mainly antiproliferative, antibacterial, antioxidant and anthelmintic effects. Isolation, synthesis and pharmacological investigation of stilbenes are increasing constantly. As Cyperaceae species are very good sources of a wide variety of stilbenes, and several of them occur in large amount worldwide, they are worthy for phytochemical and pharmacological investigations. Moreover, stilbenes are important from chemotaxonomical point of view, and they play a key role in plant defense mechanisms as well. This review summarizes the stilbenoids isolated from sedges, and their biological activities.

show abstract

Identification and ecdysteroid antagonist activity of three oligostilbenes from the seeds of Carex pendula (Cyperaceae)

Cited by 33 publications

References 13 publications

Preparative separation of oligostilbenes from Vitis thunbergii var. taiwaniana by centrifugal partition chromatography followed by Sephadex LH-20 column chromatography

Preparative separation of oligostilbenes from Vitis thunbergii var. taiwaniana by centrifugal partition chromatography followed by Sephadex LH-20 column chromatography

The Resveratrol Trimer Miyabenol C Inhibits β-Secretase Activity and β-Amyloid Generation

Chemistry and Pharmacology of Cyperaceae Stilbenoids: A Review

Contact Info

Product

Resources

About