Identification and expression analysis of 19 CC chemokine genes in orange-spotted grouper (Epinephelus coioides)

Leu, Jiann-Horng; Tsai, Chi-Hang; Tsai, Jyh-Ming; Yang, Cheng-Hsiung; Hsueh, Chih-Yuan; Chou, Hsin-Yiu

doi:10.1016/j.dci.2019.03.006

Cited by 5 publications

(2 citation statements)

References 37 publications

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“…On the other hand, previous studies in model animals showed that the CC chemokine receptor family contains at least 17 members in zebrafish ( Danio rerio ) and 10 members in medaka ( Oryzias latipes ) [ 13 , 14 ]. In aquacultured fish, 23 CC and 8 CXC chemokine receptors have been identified in channel catfish ( Ictalurus punctatus ) and 19 CC and 8 CXC chemokine receptors in orange-spotted grouper ( Epinephelus coioides ) [ 15 , 16 ]. Considering that chemokine receptors also influence how chemokines regulate immune development, homeostasis, and competence, the identification of the complete repertoire of chemokine receptors in teleost and the assessment of their functions will provide insights into the functionality of chemokines from a comparative point of view, thus contributing to boosting the immune response of fish for a sustainable development of aquaculture.…”

Section: Introductionmentioning

confidence: 99%

Pleiotropic Role of Rainbow Trout CXCRs in Response to Disease and Environment: Insights from Transcriptional Signatures and Structure Analysis

Hou,

Zhao,

Perdiguero

et al. 2024

Biomolecules

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Chemokines are cytokines with chemoattractant capacities that exert their physiological functions through the binding of chemokine receptors. Thus, chemokine and receptor complexes exert important roles in regulating development and homeostasis during routine immune surveillance and inflammation. Compared to mammals, the physiology and structure of chemokine receptors in fish have not been systematically studied. Furthermore, the salmonid-specific whole genome duplication has significantly increased the number of functional paralogs of chemokine receptors. In this context, in the current study, trout exhibited 17 cxcr genes, including 12 newly identified and 5 previously identified receptors. Interestingly, gene expression of brain cxcr1 and cxcr4, kidney cxcr3 and cxcr4, and spleen cxcr3, cxcr4, and cxcr5 subtypes were altered by bacterial infection, whereas brain cxcr1, kidney cxcr1 and cxcr7, and liver cxcr2, cxcr3, and cxcr4 subtypes were changed in response to environmental changes. Based on protein structures predicted by ColabFold, the conserved amino acids in binding pockets between trout CXCR4.1 subtypes and human CXCR4 were also analyzed. Our study is valuable from a comparative point of view, providing new insights into the identification and physiology of salmonid chemokine receptors.

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Section: Introductionmentioning

confidence: 99%

Pleiotropic Role of Rainbow Trout CXCRs in Response to Disease and Environment: Insights from Transcriptional Signatures and Structure Analysis

Hou,

Zhao,

Perdiguero

et al. 2024

Biomolecules

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“…Although the amino acid sequences of fish CCL20 share poor identities with mammalian CCL20, their three-dimensional structure and tissue distribution are relatively well conserved (Lally et al, 2003;Fu et al, 2017;Mo et al, 2015;Leu et al, 2019). Despite the observation of an increased number of fish CCL20 genes, the contributions of lineage-specific whole genome duplications (WGD), e.g.…”

Section: Introductionmentioning

confidence: 99%

Expansion of fish CCL20_like chemokines by genome and local gene duplication: Characterisation and expression analysis of 10 CCL20_like chemokines in rainbow trout (Oncorhynchus mykiss)

Liu

Wang

et al. 2020

Developmental & Comparative Immunology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Advances in chemokines of teleost fish species

Liu

2024

Aquaculture and Fisheries

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Identification and expression analysis of 19 CC chemokine genes in orange-spotted grouper (Epinephelus coioides)

Cited by 5 publications

References 37 publications

Pleiotropic Role of Rainbow Trout CXCRs in Response to Disease and Environment: Insights from Transcriptional Signatures and Structure Analysis

Pleiotropic Role of Rainbow Trout CXCRs in Response to Disease and Environment: Insights from Transcriptional Signatures and Structure Analysis

Expansion of fish CCL20_like chemokines by genome and local gene duplication: Characterisation and expression analysis of 10 CCL20_like chemokines in rainbow trout (Oncorhynchus mykiss)

Advances in chemokines of teleost fish species

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