Identification and functional analysis of risk‑related microRNAs for the prognosis of patients with bladder urothelial carcinoma

Gao, Ji; Li, Hongyan; Liu, Lei; Song, Lide; Lv, Yanting

doi:10.3892/ol.2017.7124

Cited by 5 publications

(6 citation statements)

References 35 publications

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“…MiR-6808 has been described as part of human splicing-derived miRNAs ("mirtrons") and was notably found to target the DVL1 gene, the dysregulation of which is associated with the progression of numerous cancers [20,21]. MiR-3622a-3p has been identified as significant- ly expressed in patients suffering from bladder urothelial carcinoma and associated with longer survival times [22]. In addition, miR-4441, the fourth miRNA whose seed region most frequently matched with viroids, targets the human histone deacetylase 4 (HDAC4) gene that affects transcriptional regulation, cell cycle progression, and developmental events by altering or repressing access to tar-get DNA promoters [23].…”

Section: Resultsmentioning

confidence: 99%

Sequence Similarities between Viroids and Human MicroRNAs

Bengone-Abogourin¹,

Chelkha²,

Verdin³

et al. 2019

Intervirology

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Viroids are minute unencapsidated non-coding circular RNAs known to be present and to cause diseases only in plants. Infections were associated with the occurrence of specific single-stranded RNAs similar in size to miRNAs and endogenous small interfering RNAs, and viroid pathogenicity is suspected to occur through RNA interference. We looked for sequence similarities between viroids and the seed region of human microRNAs (hsa-miRNAs). Viroid genomes were retrieved from GenBank and mature hsa-mi-RNAs were retrieved from miRBase. Two hundred 300-nucleotide-long sequences were randomly generated as controls. BLAST searches were performed using viroids as queries and hsa-miRNAs as subjects with relaxed parameters, and matches involving hsa-miRNA seed regions were considered. A total of 81,021 matches were found, and 1,501 that showed 100% identity with whole hsa-miRNA seed regions were selected. The most frequent matches involved Chrysanthemum stunt viroid or Hop stunt viroid species with hsa-miR-4286, in 365 and 207 cases, respectively. Three hsa-mi-RNAs (miR-4286, miR-6808-5p, and miR-3622a-3p) were involved in 47% of all matches between viroids and hsa-mi-RNAs. Taken together, these findings warrant further investigation on the potential of viroids and their derived small RNAs to cross kingdoms and interact with nucleic acids in humans.

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Section: Resultsmentioning

confidence: 99%

Sequence Similarities between Viroids and Human MicroRNAs

Bengone-Abogourin¹,

Chelkha²,

Verdin³

et al. 2019

Intervirology

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show abstract

“…Several earlier studies reported the prognostic performance of miRNAs for patients with bladder cancer. 12,[17][18][19][20] One of the studies evaluated the prognostic value of miRNAs in patients who underwent cystectomy and reported that miR-199a-3p and miR-214-3p are independent markers of OS. 20 It also reported that the predictive accuracy of prognostic models that are based on clinicopathological factors is improved by the inclusion of the two miRNAs (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…Several earlier studies reported the prognostic performance of miRNAs for patients with bladder cancer 12,17–20 . One of the studies evaluated the prognostic value of miRNAs in patients who underwent cystectomy and reported that miR‐199a‐3p and miR‐214‐3p are independent markers of OS 20 .…”

Section: Discussionmentioning

confidence: 99%

Serum microRNA as liquid biopsy biomarker for the prediction of oncological outcomes in patients with bladder cancer

et al. 2022

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Objectives Radical cystectomy is the gold‐standard treatment for muscle‐invasive bladder cancer and aggressive non‐muscle‐invasive bladder cancer. To enhance clinical decision‐making regarding patients with bladder cancer who underwent radical cystectomy, a recurrence prediction biomarker with high accuracy is urgently needed. In this study, we developed a model for the prediction of bladder cancer recurrence after radical cystectomy by combining serum microRNA and a pathological factor. Methods We retrospectively analyzed the clinical records of 81 patients with bladder cancer who underwent radical cystectomy between 2008 and 2016. The dataset was divided into two, and Fisher linear discriminant analysis was used to construct a prognostic model for future recurrence in the training set (n = 41). The performance of the model was evaluated in the validation set (n = 40). Results Thirty patients had recurrence after having undergone radical cystectomy. A prognostic model for recurrence was constructed by combining a pathological factor (i.e. positive pathological lymph node status) and three microRNAs (miR‐23a‐3p, miR‐3679‐3p, and miR‐3195). The model showed a sensitivity of 0.87, a specificity of 0.80, and an area under the receiver operating characteristic curve of 0.88 (0.77–0.98) in the validation set. Furthermore, Kaplan–Meier analysis revealed that patients with a low prediction index have significantly longer overall survival than patients with a high prediction index (P = 0.041). Conclusion A combination of serum microRNA profiles and lymph node statuses is useful for the prediction of oncological outcomes after radical cystectomy in patients with bladder cancer.

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“…miRNAs have been widely acknowledged as pivot regulators in all kinds of biological processes and are closely linked with the development and progression of cancers 17 . miRNAs have been shown to be promising biomarkers for tumor diagnosis or prognosis 18 . Thus, understanding the molecular mechanism of miRNAs in the process of cancer development will be of great importance.…”

Section: Discussionmentioning

confidence: 99%

miR-30c Impedes Glioblastoma Cell Proliferation and Migration by Targeting SOX9

Liu

Zhuang

2019

oncol res

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MiR-30c has been acknowledged as a tumor suppressor in various human cancers, such as ovarian cancer, gastric cancer and prostate cancer. However, the role of miR-30c in glioblastoma (GBM) needs to be investigated. In our study, we found that the expression of miR-30c was significantly downregulated in GBM tissues and cell lines. We found that overexpression of miR-30c inhibited cellular proliferation of GBM cells and. More GBM cells were arrested in G0 phase after miR-30c overexpression. Moreover, we showed that miR-30c overexpression suppressed the migration and invasion of GBM cells. In mechanism, we found that SOX9 was a direct target of miR-30c in GBM cells. Overexpression of miR-30c inhibited the mRNA and protein levels of SOX9 in GBM cells. Moreover, there was a negative correlation between the expression of miR-30c and SOX9 in GBM tissues. Finally, we showed that restoration of SOX9 in GBM cells reversed the proliferation, migration and invasion of GBM cells transfected with miR-30c mimics. Collectively, our results demonstrated that miR-30c suppressed the proliferation, migration and invasion of GBM cells via targeting SOX9.

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Identification and functional analysis of risk‑related microRNAs for the prognosis of patients with bladder urothelial carcinoma

Cited by 5 publications

References 35 publications

Sequence Similarities between Viroids and Human MicroRNAs

Sequence Similarities between Viroids and Human MicroRNAs

Serum microRNA as liquid biopsy biomarker for the prediction of oncological outcomes in patients with bladder cancer

miR-30c Impedes Glioblastoma Cell Proliferation and Migration by Targeting SOX9

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