Identification and Functional Characterization of Plant Toxins

Adamski, Zbigniew; Bufo, Sabino Aurelio; Milella, Luigi; Scrano, Laura

doi:10.3390/toxins13030228

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…A prominent and evolutionarily stable strategy in plants is the production of toxic, repellent, or anti-nutritive metabolites [ 2 ]. These substances protect plants against herbivores, limit plant feeding, and decrease plant biomass loss [ 3 ]. Many such compounds are toxic to herbivores and vertebrates, including humans.…”

Section: Introductionmentioning

confidence: 99%

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New Analytical Approach to Quinolizidine Alkaloids and Their Assumed Biosynthesis Pathways in Lupin Seeds

Namdar,

Mulder,

Ben-Simchon

et al. 2024

Toxins

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Alkaloids play an essential role in protecting plants against herbivores. Humans can also benefit from the pharmacological effects of these compounds. Plants produce an immense variety of structurally different alkaloids, including quinolizidine alkaloids, a group of bi-, tri-, and tetracyclic compounds produced by Lupinus species. Various lupin species produce different alkaloid profiles. To study the composition of quinolizidine alkaloids in lupin seeds, we collected 31 populations of two wild species native to Israel, L. pilosus and L. palaestinus, and analyzed their quinolizidine alkaloid contents. Our goal was to study the alkaloid profiles of these two wild species to better understand the challenges and prospective uses of wild lupins. We compared their profiles with those of other commercial and wild lupin species. To this end, a straightforward method for extracting alkaloids from seeds and determining the quinolizidine alkaloid profile by LC–MS/MS was developed and validated in-house. For the quantification of quinolizidine alkaloids, 15 analytical reference standards were used. We used GC–MS to verify and cross-reference the identity of certain alkaloids for which no analytical standards were available. The results enabled further exploration of quinolizidine alkaloid biosynthesis. We reviewed and re-analyzed the suggested quinolizidine alkaloid biosynthesis pathway, including the relationship between the amino acid precursor l-lysine and the different quinolizidine alkaloids occurring in seeds of lupin species. Revealing alkaloid compositions and highlighting some aspects of their formation pathway are important steps in evaluating the use of wild lupins as a novel legume crop.

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Section: Introductionmentioning

confidence: 99%

“…Many such compounds are toxic to herbivores and vertebrates, including humans. They are also harmful to other microorganisms, such as viruses, bacteria, and fungi, and thus, could be natural biocides to help combat pathogens and treat diseases, including cancers [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

New Analytical Approach to Quinolizidine Alkaloids and Their Assumed Biosynthesis Pathways in Lupin Seeds

Namdar,

Mulder,

Ben-Simchon

et al. 2024

Toxins

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Exosomes as mediators of signal transmitters in biotoxins toxicity: a comprehensive review

Xu,

Huangfu,

et al. 2024

Cell Biol Toxicol

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Small membranes known as exosomes surround them and are released by several cell types both in vitro and in vivo. These membranes are packed with a variety of biomolecules, including proteins, lipids, deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and non-coding RNA (ncRNA). As a source of biological nanomaterials, exosomes play a role in information and substance transmission between cells and have been identified as a general method of facilitating communication during interactions between the body, target organs, and toxins.. In order to understand the changes and mechanism of the composition and level of exosomes after biotoxin infection, this review focuses on current findings on the exosomes and highlights their novel uses in the toxicity mechanism. Exosomes are mainly used as a delivery carrier or mediated by receptors, and play an immune role after the toxin enters the body. This review expounds on the importance of exosomes in the toxicological mechanism of biotoxins and provides new insights for further diagnosis of toxic biomarkers, detoxification, and treatment development. Graphical abstract

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A necessary considering factor for crop resistance: Precise regulation and effective utilization of beneficial microorganisms

Kou,

Song,

et al. 2024

New Crops

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Identification and Functional Characterization of Plant Toxins

Abstract: The evolutionary arms race between plants and herbivores has led, over millions of years, to the production of many substances that prevent plants from being over-eaten by plant-feeding animals [...]

Cited by 3 publications

References 9 publications

New Analytical Approach to Quinolizidine Alkaloids and Their Assumed Biosynthesis Pathways in Lupin Seeds

New Analytical Approach to Quinolizidine Alkaloids and Their Assumed Biosynthesis Pathways in Lupin Seeds

Exosomes as mediators of signal transmitters in biotoxins toxicity: a comprehensive review

A necessary considering factor for crop resistance: Precise regulation and effective utilization of beneficial microorganisms

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