Identification and functional characterization of mouse TPO1 as a myelin membrane protein

Fukazawa, Nobuna; Ayukawa, Katsuhiko; Nishikawa, Kaori; Ohashi, Hiroki; Ichihara, Nobutsune; Hikawa, Yuki; Abe, Toshiaki; Kudo, Yoshihisa; Kiyama, Hiroshi; Wada, Keiji; Aoki, Shunsuke

doi:10.1016/j.brainres.2005.11.069

Cited by 6 publications

(2 citation statements)

References 47 publications

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“…Among these myelination-related mRNAs, Olig2, Hexa, Myo5a, Serinc5, and Tgfb1 were significantly upregulated, whereas Pmp22 and Ugt8a were downregulated. The significant upregulation of Serinc5 at 14 days, which promotes myelination through activation of the kinase Fyn in development of the peripheral nervous system, 43 demonstrates the general mechanisms that are present in both myelination development and remyelination after injury. In addition, at 3 and 7 days postinjury, downregulation of Pmp22, which encodes a protein involved in formation and maintenance of myelin, 44 may be associated with demyelination by Schwann cells in the early stages after injury.…”

Section: Discussionmentioning

confidence: 97%

Gene expression analysis at multiple time-points identifies key genes for nerve regeneration

et al. 2016

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Section: Discussionmentioning

confidence: 97%

Gene expression analysis at multiple time-points identifies key genes for nerve regeneration

et al. 2016

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“…Interestingly, the myelin membrane protein TPO1, which has also been proposed to activate Fyn, is highly enriched both in the Golgi and in the Fyn-positive sheets of myelinating oligodendrocytes (Fukazawa et al, 2006;Jain and Ganesh, 2016). Thus, the fine regulation of myelin formation and maintenance appear to depend on trafficking through the Golgidependent secretory pathway and microtubule network and signaling pathways in both oligodendrocytes and the neurons, and on their functional interactions at specific sites.…”

Section: Role Of the Golgi Apparatus Inmentioning

confidence: 99%

Golgi trafficking defects in postnatal microcephaly: The evidence for “Golgipathies”

Passemard

Perez

Colin-Lemesre

et al. 2017

Progress in Neurobiology

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The Golgi apparatus plays a central role in cell homeostasis, not only in processing and maturing newly synthesized proteins and lipids but also in orchestrating their sorting, packing, routing and recycling on the way to their final destination. These multiple secretory pathways require a complex ballet of vesicular and tubular carriers that continuously bud off from donor membranes and fuse to acceptor membranes. Membrane trafficking is particularly prominent in axons, where cargo molecules have a long way to travel before they reach the synapse, and in oligodendrocytes, which require an immense increase in membrane surface in order to sheathe axons in myelin. Interestingly, in recent years, genes encoding Golgi-associated proteins with a role in membrane trafficking have been found to be defective in an increasing number of inherited disorders whose clinical manifestations include postnatal-onset microcephaly (POM), white matter defects and intellectual disability. Several of these genes encode RAB GTPases, RAB-effectors or RAB-regulating proteins, linking POM and intellectual disability to RAB-dependent Golgi trafficking pathways and suggesting that their regulation is critical to postnatal brain maturation and function. Here, we review the key roles of the Golgi apparatus in post-mitotic neurons and the oligodendrocytes that myelinate them, and provide an overview of these Golgi-associated POM-causing genes, their function in Golgi organization and trafficking and the likely mechanisms that may link dysfunctions in RAB-dependent regulatory pathways with POM.

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Characterization of Fyn signaling on the age-dependent immuno-modulation on traumatic rats

et al. 2009

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Identification and functional characterization of mouse TPO1 as a myelin membrane protein

Cited by 6 publications

References 47 publications

Gene expression analysis at multiple time-points identifies key genes for nerve regeneration

Gene expression analysis at multiple time-points identifies key genes for nerve regeneration

Golgi trafficking defects in postnatal microcephaly: The evidence for “Golgipathies”

Characterization of Fyn signaling on the age-dependent immuno-modulation on traumatic rats

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