1990
DOI: 10.1128/mcb.10.10.5486
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Identification and functional characterization of the human T-cell receptor beta gene transcriptional enhancer: common nuclear proteins interact with the transcriptional regulatory elements of the T-cell receptor alpha and beta genes.

Abstract: A transcriptional enhancer has been mapped to a region 5.5 kilobases 3' of the C(2 gene in the human T-cell receptor (TCR) 1-chain locus. Transient

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Cited by 111 publications
(139 citation statements)
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“…(29,30). Although these sites were identified earlier, a consensus opinion on their function in the TCR␤ enhancer had proven hard to establish (20,21) until the recent studies of the human TCR␤ enhancer (23). Our observations conclusively demonstrate that individual elements of both composite motifs are essential for activity of the murine TCR␤ enhancer.…”
Section: Figuresupporting
confidence: 64%
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“…(29,30). Although these sites were identified earlier, a consensus opinion on their function in the TCR␤ enhancer had proven hard to establish (20,21) until the recent studies of the human TCR␤ enhancer (23). Our observations conclusively demonstrate that individual elements of both composite motifs are essential for activity of the murine TCR␤ enhancer.…”
Section: Figuresupporting
confidence: 64%
“…Alignment of the murine and human ␤ enhancer sequences show that the murine ␤E1 and ␤E2 motifs (including a GATA site) fall within T␤2, ␤E4 falls within T␤3, ␤E5 and ␤E6 fall within T␤4, and ␤E7 falls within T␤5. Mutations or deletion of T␤2 and T␤3 reduced enhancer 30 -50% (20). Deletions of T␤4 gave more variable results, reducing activity to 10% (20) or 40% (21) in two different studies.…”
Section: Functional Analysis Of the Murine Tcr␤-chain Gene Enhancer 1mentioning
confidence: 99%
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