Identification and localization of multiple classic cadherins in developing rat limbic system

Bekirov, Iddil H.; Needleman, Leigh A.; Zhang, W; Benson, Deanna L.

doi:10.1016/s0306-4522(02)00375-5

Cited by 78 publications

(87 citation statements)

References 67 publications

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“…For example, cadherin 10, which we found to be 25-fold enriched in Merkel cells, is an adhesion molecule that is thought to regulate the formation of specific neuronal connections (35).…”

Section: Isolating Merkel Cellsmentioning

confidence: 85%

Molecular profiling reveals synaptic release machinery in Merkel cells

Haeberle

Fujiwara

Chuang

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

160

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“…For example, cadherin 10, which we found to be 25-fold enriched in Merkel cells, is an adhesion molecule that is thought to regulate the formation of specific neuronal connections (35).…”

Section: Isolating Merkel Cellsmentioning

confidence: 85%

Molecular profiling reveals synaptic release machinery in Merkel cells

Haeberle

Fujiwara

Chuang

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

160

200

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“…Classic cadherins are synaptic adhesion proteins that have been implicated in initial stages of synapse formation based on brief periods of overexpression of dominant-negative mutants in young neurons (Togashi et al, 2002). Differential localization of cadherins implicates them in synapse targeting as well (Arndt and Redies, 1996, Fannon and Colman, 1996, Suzuki et al, 1997, Bekirov et al, 2002, Gil et al, 2002. It is an open question whether the actions of classic cadherins are required initially for synapse assembly in neurons of any age, whether their actions on assembly are exerted presynaptically, postsynaptically, or trans-synaptically and whether cadherins coordinate the subcellular localization of excitatory and inhibitory synapses.…”

Section: Introductionmentioning

confidence: 99%

“…While individual neurons express several cadherins simultaneously, particular cadherins tend to predominate within interconnected groups of neurons (Arndt and Redies, 1996, Suzuki et al, 1997, Bekirov et al, 2002, Gil et al, 2002 leading to the widely touted notion that adhesion between likecadherins may be important for synapse recognition (Fannon and Colman, 1996, Serafini, 1999, Shapiro and Colman, 1999. In support of this idea, N-cadherin is important for generating layer specific connections Sanes, 1997, Poskanzer et al, 2003), Nand E-cadherin parse to different dendritic domains in hippocampus (Fannon and Colman, 1996), and N-cadherin becomes concentrated solely at excitatory synapses in several brain areas (Benson and Tanaka, 1998).…”

Section: Introductionmentioning

confidence: 99%

Temporally distinct demands for classic cadherins in synapse formation and maturation

Bozdagi

Valcin

Poskanzer

et al. 2004

Molecular and Cellular Neuroscience

115

113

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Classic cadherins are synaptic adhesion proteins that have been implicated in synapse formation and targeting. Brief inactivation of classic cadherin function in young neurons appears to abrogate synapse formation when examined acutely. It remains unknown whether such abrogation is unique to young neurons, whether it occurs by stalling neuronal maturation or by directly interfering with the process of synapse assembly, and whether synapse targeting is altered. Here we asked whether sustained pan-cadherin blockade would prevent or alter the progression of axonal and dendritic outgrowth, synaptogenesis and the stereotypic distribution of excitatory and inhibitory synapses on cultured hippocampal neurons. While pre-and postsynaptic cadherins are required for synapse assembly in young neurons, we find that in neurons older than 10 days, classic cadherins are entirely dispensable for joining and aligning presynaptic vesicle clusters with molecular markers of the postsynaptic density. Further, we find the proportion and relative distributions of excitatory and inhibitory terminals on single neurons is not altered. However, synapse formation on neurons in which cadherin function is blocked are smaller; such synapses exhibit decreased synaptic vesicle recycling and a decreased frequency of spontaneous EPSCs. Moreover, such synapses fail to acquire resistance to F-actin depolymerization, a hallmark of mature, stable contacts. These data provide new evidence that cadherins are required to promote synapse stabilization and structural and functional maturation, but dispensable for the correct subcellular distribution of excitatory and inhibitory synapses.

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“…the retinal ganglion cells and their major projecting target the optic tectum) (Fushimi et al, 1997;Kools et al, 1999). Moreover, similar to the chicken (Fushimi et al, 1997) and rat (Bekirov et al, 2002) cdh10 expression in the zebrafish CNS is distinct from expression patterns of other classic cadherins such as cdh1 (Babb et al, 2001), cdh2 (Bitzur et al, 1994), cdh4 (Liu et al, 1999) and cdh6 (Liu et al, 2006).…”

Section: Cdh10 Expression In the Central Nervous Systemmentioning

confidence: 97%

“…Information on Cdh10/cdh10 expression in the vertebrate is relatively scarce compared to most other classic cadherins. So far Cdh10/cdh10 distribution pattern has been examined in chicken central nervous system (Fushimi et al, 1997), in rat limbic system (Bekirov et al, 2002) and in human total RNA from various tissue samples (Kools et al, 1999). To the best of our knowledge, there is no information on Cdh10/cdh10 expression in the vertebrate peripheral system.…”

mentioning

confidence: 99%

Expression of cadherin10, a type II classic cadherin gene, in the nervous system of the embryonic zebrafish

Liu

Duff

Liu

et al. 2006

Gene Expression Patterns

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Cadherins are cell surface adhesion molecules that play important roles in development of tissues and organs. In this study we analyzed expression pattern of cadherin10, a member of the type II classic cadherin subfamily, in the embryonic zebrafish using in situ hybridization methods. cadherin10 message (cdh10) is first and transiently expressed by the notochord. In the developing nervous system, cdh10 was first detected in a subset of the cranial ganglia, then in restricted brain regions and neural retina. As development proceeds, cdh10 expression domain and/or expression levels increased in the embryonic nervous system. Our results show that cdh10 expression in the zebrafish developing nervous system is both spatially and temporally regulated.

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Identification and localization of multiple classic cadherins in developing rat limbic system

Cited by 78 publications

References 67 publications

Molecular profiling reveals synaptic release machinery in Merkel cells

Molecular profiling reveals synaptic release machinery in Merkel cells

Temporally distinct demands for classic cadherins in synapse formation and maturation

Expression of cadherin10, a type II classic cadherin gene, in the nervous system of the embryonic zebrafish

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