Identification and pathogenicity of a novel genotype avian hepatitis E virus from silkie fowl (gallus gallus)

Liu, Baoyuan; Chen, Yiyang; Zhao, Liang; Zhang, Meimei; Ren, Xiaolei; Yuan, Zihao; Zhang, Beibei; Fan, Mengnan; Zhao, Qin; Zhou, En‐Min

doi:10.1016/j.vetmic.2020.108688

Cited by 19 publications

(23 citation statements)

References 37 publications

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“…The first cluster contained two sequences and was related to the prototype aHEV NC023425 in genotype 2 (81.4–83.3% nucleotide identity). The remaining seven sequences built one cluster (95.4%–100% nucleotide sequence identity) which showed a nucleotide sequence identity to all other known aHEV strains between 74.4% and 84.2% with the highest sequence identity (82.8–84.2%) to a potential novel genotype (MN652265), isolated from a Silkie fowl in China [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

“…Genotype 3 is prevalent in chickens in Europe [ 23 ], China, and North America [ 24 ], while genotype 4 has been reported from chickens in Hungary and apparently healthy chickens in Taiwan [ 17 , 18 , 21 , 25 , 26 , 27 ]. Recently, aHEV strains isolated from China and Pakistan have been proposed to belong to novel genotypes [ 7 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

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Identification of a Putative Novel Genotype of Avian Hepatitis E Virus from Apparently Healthy Chickens in Southwestern Nigeria

Osamudiamen

Akanbi

Zander

et al. 2021

Viruses

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Avian hepatitis E virus (aHEV) is the major etiological agent of hepatitis-splenomegaly syndrome (HSS), big liver and spleen disease (BLSD), and hepatic rupture hemorrhage syndrome (HRHS) in chickens. Infections with aHEV cause a significant decrease in egg production and increased mortality in chickens worldwide. However, studies on the prevalence of aHEV in Nigeria are scarce. In this study, serum (n = 88) and fecal samples (n = 110) obtained from apparently healthy layer chickens from three states in southwestern Nigeria were analyzed by nested reverse transcription-polymerase chain reaction (nRT-PCR) targeting the helicase and capsid gene for the presence of aHEV. Avian HEV was detected in 12.5% (n = 11/88) of serum samples and 9.1% (n = 10/110) of fecal samples tested. Phylogenetic analysis showed that five of the twelve identified aHEV sequences belonged to genotype 2. The remaining seven sequences were only distantly related to other known aHEV isolates. After amplification of the near-complete ORF2 fragment (1618 bp) and part of the ORF1 (582 bp) of isolate YF40_aHEV_NG phylogenetic analysis revealed a nucleotide sequence identity between 79.0 and 82.6% and 80.1 and 83.5%, respectively, to other known aHEV strains, indicating that the Nigerian isolate YF40_aHEV_NG belongs to a novel aHEV genotype. This is the first report of co-circulation of aHEV genotypes in chickens in Nigeria.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Identification of a Putative Novel Genotype of Avian Hepatitis E Virus from Apparently Healthy Chickens in Southwestern Nigeria

Osamudiamen

Akanbi

Zander

et al. 2021

Viruses

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“…Finally, HEV-8 has been detected in Bactrian camels [ 50 , 51 ]. In addition, there are many as-yet unclassified HEV strains identified from moose [ 52 , 53 ], tree shrew (GenBank accession number KR905549), sparrow [ 54 ], silkie fowl [ 55 ], little egret [ 56 ], hamster [ 57 ], voles [ 58 , 59 ], and various bats [ 60 ].…”

Section: Genome and Classificationmentioning

confidence: 99%

Mechanism of Cross-Species Transmission, Adaptive Evolution and Pathogenesis of Hepatitis E Virus

Primadharsini

Nagashima

Okamoto

2021

Viruses

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Hepatitis E virus (HEV) is the leading cause of acute hepatitis worldwide. While the transmission in developing countries is dominated by fecal-oral route via drinking contaminated water, the zoonotic transmission is the major route of HEV infection in industrialized countries. The discovery of new HEV strains in a growing number of animal species poses a risk to zoonotic infection. However, the exact mechanism and the determinant factors of zoonotic infection are not completely understood. This review will discuss the current knowledge on the mechanism of cross-species transmission of HEV infection, including viral determinants, such as the open reading frames (ORFs), codon usage and adaptive evolution, as well as host determinants, such as host cellular factors and the host immune status, which possibly play pivotal roles during this event. The pathogenesis of hepatitis E infection will be briefly discussed, including the special forms of this disease, including extrahepatic manifestations, chronic infection, and fulminant hepatitis in pregnant women.

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“…The mitochondrial damage triggered the apoptosis signaling pathway, leading to the necrosis and cell death of renal epithelial cells in the acute phase of HEV infection [ 91 ]. In addition, loss in mitochondrial cristae and swollen mitochondria were observed in HEV-infected hepatocytes via transmission electron microscopy [ 92 ]. These results suggest that mitochondrial lesions may be biomarkers of HEV infection.…”

Section: Cellular Organelles and Proteins Involved In Hev Translation And Replicationmentioning

confidence: 99%

Cellular Organelles Involved in Hepatitis E Virus Infection

2021

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Hepatitis E virus (HEV), a major cause of acute hepatitis worldwide, infects approximately 20 million individuals annually. HEV can infect a wide range of mammalian and avian species, and cause frequent zoonotic spillover, increasingly raising public health concerns. To establish a successful infection, HEV needs to usurp host machineries to accomplish its life cycle from initial attachment to egress. However, relatively little is known about the HEV life cycle, especially the functional role(s) of cellular organelles and their associated proteins at different stages of HEV infection. Here, we summarize current knowledge regarding the relation of HEV with the different cell organelles during HEV infection. Furthermore, we discuss the underlying mechanisms by which HEV infection is precisely regulated in infected cells and the modification of host cell organelles and their associated proteins upon HEV infection.

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Identification and pathogenicity of a novel genotype avian hepatitis E virus from silkie fowl (gallus gallus)

Cited by 19 publications

References 37 publications

Identification of a Putative Novel Genotype of Avian Hepatitis E Virus from Apparently Healthy Chickens in Southwestern Nigeria

Identification of a Putative Novel Genotype of Avian Hepatitis E Virus from Apparently Healthy Chickens in Southwestern Nigeria

Mechanism of Cross-Species Transmission, Adaptive Evolution and Pathogenesis of Hepatitis E Virus

Cellular Organelles Involved in Hepatitis E Virus Infection

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