Identification and quantification of bisphenol A and bisphenol B in polyvinylchloride and polycarbonate medical devices by gas chromatography with mass spectrometry

Abstract

A gas chromatography with mass spectrometry method has already been developed and published for the identification and quantification of 14 phthalates and five nonphthalate plasticizers in polyvinylchloride medical devices. In order to assay, in addition to plasticizers, bisphenols A and B possibly present in polyvinylchloride samples, this previous method was extended to the assay of these additional potential endocrine disruptors. Furthermore, as bisphenol A could also be present in polycarbonate samples, the method used for the polyvinylchloride sample was tested and validated for the assay of bisphenols A and B in polycarbonate medical devices. The separation of all compounds, including bisphenols A and B, is obtained on a cross-linked 5%-phenyl/95%-dimethylpolysiloxane capillary column using a temperature gradient. For both plastics, samples are dissolved in tetrahydrofuran followed by a precipitation of the plastic by addition of ethanol. Results obtained point out residual bisphenol A amounts for polycarbonate samples ranging from 0.6 to 0.8% and for polyvinylchloride samples less or equal to 5 ppm. No bisphenol B was detected in the samples tested. For bisphenols A and B, mean recoveries obtained on spiked polyvinylchloride or polycarbonate sample preparations ranged from 87 to 108% in accordance with in-house specification (80-110%).

Neurodevelopmental Disorders and Environmental Toxicants: Epigenetics as an Underlying Mechanism

“…Bisphenol A (BPA) is a chemical predominantly polymerized or modified and used in the plastic industry; thus, it is used in a wide range of consumer goods and commodities, especially in daily used food and beverage containers, dispensers, baby bottles, microwave cookware [73], or in healthcare-related products such as medical devices [74] or dental composite resins [75]. However, incomplete reaction or degradation of the polymer may release residual monomers of BPA.…”

Presence of Bisphenol A and Parabens in a Neonatal Intensive Care Unit: An Exploratory Study of Potential Sources of Exposure

“…Bisphenol A (BPA) is a high-production volume chemical commonly used in the manufacturing of epoxy resins and polycarbonate plastics and as an additive in many other plastics, for example, polyvinyl chloride (PVC) (Gimeno et al 2015). Parabens (PBs) are a family of alkyl esters of p-hydroxybenzoic acid [methylparaben (MeP), ethylparaben (EtP), propylparaben (PrP), and butylparaben (BuP) congeners].…”

“…LBW infants are also more likely to require medical appliances in intimate contact with them, including a) bags of intravenous (IV) fluids and total parenteral nutrition; b) nasogastric and enteral feeding tubes, respiratory masks/endotracheal tubes, and venous catheters; and c) cardiopulmonary bypass circuits, among others. Many of these medical devices are made of polycarbonate or PVC plastics, in which residual nonpolymerized BPA can remain after the polymerization process and may leach from the product (Gimeno et al 2015). BPA may also leach after hydrolysis of the polymer under certain conditions (EU 2010;Mercea 2009), and its release is greater with longer contact time, higher temperature, and elevated pH (as in hydroxide aqueous solutions) (Geens et al 2011(Geens et al , 2012.…”

Investigation of 1-Dodecylimidazolinm Modified Filter Papers as a Thin-Film Microextraction Phase for the Preconcentration of Bisphenol A from Plant Oil Samples

“…1,2 Due to its widespread use, residues of BPA have been often detected in water, soil, air, medical devices and foods. [3][4][5][6][7] BPA, which is one of the most representative compounds of environmental endocrine disrupting chemicals (EDCs), causes cardiovascular disease, diabetes, neuro-behavioral disorders, carcinogenic hypersensitivity, and reproductive impairment, even at low concentrations. [8][9][10] Plant oil is a usual commodity in human nutrition.…”