2023
DOI: 10.18632/aging.205099
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Identification and validation of a cancer-associated fibroblasts-related scoring system to predict prognosis and immune landscape in hepatocellular carcinoma through integrated analysis of single-cell and bulk RNA-sequencing

Lingling Bao,
Xuede Zhang,
Wenjuan Wang
et al.

Abstract: Background: Cancer-associated fibroblasts (CAFs) regulate the malignant biological behaviour of hepatocellular carcinoma (HCC) as a significant component of the tumour immune microenvironment (TIME). This study aimed to develop a CAFs-based scoring system to predict the prognosis and TIME of patients with HCC. Methods: Data for the TCGA-LIHC and GSE14520 cohorts were downloaded from The Cancer Genome Atlas and the Gene Expression Omnibus databases. Single-cell RNA-sequencing data for HCC samples wer… Show more

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“…The Human Protein Atlas (HPA) was performed to obtain immunohistochemical staining images [ 20 ] (V.22.0, https://www.proteinatlas.org ) ( Supplementary Table 1 ). Tregs-related genes (TRGs) were downloaded from the Genecards ( https://www.genecards.org/ ) ( Supplementary Table 2 ) [ 21 ].…”
Section: Methodsmentioning
confidence: 99%
“…The Human Protein Atlas (HPA) was performed to obtain immunohistochemical staining images [ 20 ] (V.22.0, https://www.proteinatlas.org ) ( Supplementary Table 1 ). Tregs-related genes (TRGs) were downloaded from the Genecards ( https://www.genecards.org/ ) ( Supplementary Table 2 ) [ 21 ].…”
Section: Methodsmentioning
confidence: 99%