2022
DOI: 10.3389/fendo.2022.1001634
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Identification and validation of a signature involving voltage-gated chloride ion channel genes for prediction of prostate cancer recurrence

Abstract: Voltage-gated chloride ion channels (CLCs) are transmembrane proteins that maintain chloride ion homeostasis in various cells. Accumulating studies indicated CLCs were related to cell growth, proliferation, and cell cycle. Nevertheless, the role of CLCs in prostate cancer (PCa) has not been systematically profiled. The purpose of this study was to investigate the expression profiles and biofunctions of CLCs genes, and construct a novel risk signature to predict biochemical recurrence (BCR) of PCa patients. We … Show more

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Cited by 5 publications
(3 citation statements)
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“…The VGCLC family has nine different members which respond depolarization with an Cl − inward flow at positive potentials, such as CIC-1 used in skeletal muscle, to maintain resting transmembrane potential. VGCLC plays a significant role in cellular survival, proliferation, colony formation, migration and malignancy [ 90 , 91 ]. Within organelles, VGCLC also participates volume regulation, transport of anionic substrates, and electroneutrality remaining [ 92 ].…”
Section: Endogenous Electrical Signalsmentioning
confidence: 99%
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“…The VGCLC family has nine different members which respond depolarization with an Cl − inward flow at positive potentials, such as CIC-1 used in skeletal muscle, to maintain resting transmembrane potential. VGCLC plays a significant role in cellular survival, proliferation, colony formation, migration and malignancy [ 90 , 91 ]. Within organelles, VGCLC also participates volume regulation, transport of anionic substrates, and electroneutrality remaining [ 92 ].…”
Section: Endogenous Electrical Signalsmentioning
confidence: 99%
“…Thus, it is crucial to decide the site of electrodes and current direction according to the target cell/tissue type and purpose. Considering injured skin as an example, a short-circuiting of the transepithelial potential results in a more negatively charged wound compared to the surrounding tissue [ 91 ]. When a fracture occurs, fracture site also turns negatively charged [ 47 , 186 ].…”
Section: Exogenous Electric Stimulationmentioning
confidence: 99%
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