2019
DOI: 10.3389/fgene.2019.01252
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Identification and Validation of an Immune-Related RNA Signature to Predict Survival of Patients With Head and Neck Squamous Cell Carcinoma

Abstract: Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease characterized by different molecular subgroups and clinical features. Therefore, it is important to uncover reliable molecular biomarkers for distinguishing different risk patient subgroup. Here, we conducted a multi-omics analysis to examine the joint predictive power of a multi-type RNA signature in the prognosis of HNSCC patients through integration analysis of mRNA, miRNA, and lncRNA expression profiles and clinical data in a large nu… Show more

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Cited by 16 publications
(14 citation statements)
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“…14 On the one hand, Mantovani et al confirmed that TAMs produce growth factors and cytokines promoting cancer cell proliferation but, on the other hand, preclinical evaluations showed that a reduction in TAMs did not affect tumor cell proliferation. 15,16 TAMs in the TME cooperate with cancer stem cells (CSCs) to maintain stemness. In HNSCC, the activation of PI3K-4EBP1-SOX2 regulates some CSC properties and it may increase fibrosis/stroma/ECM escape.…”
Section: Tme Cells: Tamsmentioning
confidence: 99%
See 1 more Smart Citation
“…14 On the one hand, Mantovani et al confirmed that TAMs produce growth factors and cytokines promoting cancer cell proliferation but, on the other hand, preclinical evaluations showed that a reduction in TAMs did not affect tumor cell proliferation. 15,16 TAMs in the TME cooperate with cancer stem cells (CSCs) to maintain stemness. In HNSCC, the activation of PI3K-4EBP1-SOX2 regulates some CSC properties and it may increase fibrosis/stroma/ECM escape.…”
Section: Tme Cells: Tamsmentioning
confidence: 99%
“…On the one hand, Mantovani et al confirmed that TAMs produce growth factors and cytokines promoting cancer cell proliferation but, on the other hand, preclinical evaluations showed that a reduction in TAMs did not affect tumor cell proliferation. 15 , 16 …”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, our model has a better ability of predicting prognosis for HNSCC than that of TNM staging, with increased AUC (Area Under Curve) values being obtained with ROC analysis. In addition, our model shows a better prognostic capacity based on AUC values as compared with previously published models based on TCGA HNSCC database analysis [41][42][43]. The enhanced ability of our model in evaluating the prognosis of HNSCC should substantially improve the clinical treatment of this condition.…”
Section: Discussionmentioning
confidence: 69%
“…However, the role of immune-related lnRNAs (irlncRNAs) in OSs has not yet been well classified. Several studies of other types of cancer have shown that several irlncRNAs could be biomarkers for pancreatic cancer, head and neck squamous cell carcinoma, and clear cell renal cell carcinoma (11)(12)(13). Notably, Yang et al investigated the relationship between the TME and OSs metastasis (14).…”
Section: Introductionmentioning
confidence: 99%