2019
DOI: 10.1016/j.ijpara.2019.01.006
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Identification of a new panel of reference genes to study pairing-dependent gene expression in Schistosoma mansoni

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Cited by 15 publications
(31 citation statements)
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“…In this context, a S. mansoni ortholog of follistatin ( Sm Fst; Smp_123300) was found to be differentially transcribed with an interesting bias toward sM. The latter was independently confirmed by a subsequent RNA-seq approach including paired and unpaired adults and their gonads (Lu et al, 2016; Lu et al, 2017) as well as by independent quantitative polymerase chain reaction (qPCR) analyses (Leutner et al, 2013; Haeberlein et al, 2019). Based on the corresponding results from microarray, SuperSAGE, RNA-seq, and qPCRs, all exhibiting higher transcript occurrence in sM, Sm Fst is probably the most intensively studied gene with respect to expression profiling.…”
Section: Transcriptomic Performance Of Male Schistosomesmentioning
confidence: 83%
See 1 more Smart Citation
“…In this context, a S. mansoni ortholog of follistatin ( Sm Fst; Smp_123300) was found to be differentially transcribed with an interesting bias toward sM. The latter was independently confirmed by a subsequent RNA-seq approach including paired and unpaired adults and their gonads (Lu et al, 2016; Lu et al, 2017) as well as by independent quantitative polymerase chain reaction (qPCR) analyses (Leutner et al, 2013; Haeberlein et al, 2019). Based on the corresponding results from microarray, SuperSAGE, RNA-seq, and qPCRs, all exhibiting higher transcript occurrence in sM, Sm Fst is probably the most intensively studied gene with respect to expression profiling.…”
Section: Transcriptomic Performance Of Male Schistosomesmentioning
confidence: 83%
“…Based on the corresponding results from microarray, SuperSAGE, RNA-seq, and qPCRs, all exhibiting higher transcript occurrence in sM, Sm Fst is probably the most intensively studied gene with respect to expression profiling. Thus, it can be used in future studies as a marker for differential transcription in bM versus sM (Haeberlein et al, 2019). Follistatins are known antagonists in TGFβ signaling pathways and block ligands of the TGFβ family such as TGFβ, activin, and bone morphogenetic protein (BMP) (Massagué and Chen, 2000; Moustakas and Heldin, 2009; Heldin and Moustakas, 2016).…”
Section: Transcriptomic Performance Of Male Schistosomesmentioning
confidence: 99%
“…The large number of eggs produced by mature females plays a central role in the pathology of infection with this parasite and in disease spread. Previous research suggested that the sexual development of the female schistosome depends on appropriate signals provided directly or indirectly by the male during pairing [4][5][6][7][8][9][10][11][12][13]. Thus, understanding the mechanism of female development as a consequence of pairing may lead to novel concepts for impeding egg production to lessen the spread of schistosomiasis.…”
Section: Introductionmentioning
confidence: 99%
“…Male schistosomes undergo normal morphological development, whether isolated from single-sex or bisexual infections, although some differences between males from single, as opposed to bisexual, infections have been reported (Aronstein and Strand, 1984). Very recently, several genes have been found to be up-regulated in males derived from single-sex male worm infections compared with males from bisexual infections (Haeberlein et al, 2019). Reproductive development in the male seems not significantly influenced by the presence of the female.…”
Section: Schistosome Sexual Biologymentioning
confidence: 99%
“…In light of the observation of extensive apoptotic vitelline cell death in reproductively impaired female worms (Galanti et al, 2012), it is noteworthy that TGF-β has an anti-apoptotic effect (Schuster and Krieglstein, 2002). It is of interest that Smfst is one of the genes up-regulated in S. mansoni males from single sex infections when compared with males from worm pairs (Haeberlein et al, 2019). Smfst is a follistatin orthologue and follistatins are known to be negative regulators of TGF-beta signalling pathways and thus negatively influence TGF-induced signal transduction.…”
Section: Tgf-β and Schistosomesmentioning
confidence: 99%