2011
DOI: 10.1089/mdr.2010.0040
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Identification of a Novel Keyhole Phenotype in Double-Disk Diffusion Assays of Clindamycin-Resistant Erythromycin-Sensitive Strains of Streptococcus agalactiae

Abstract: Our objective was to characterize 46 unique, erythromycin-sensitive, and clindamycin-resistant Streptococcus agalactiae strains from S. Korea that displayed a novel phenotype in double-disk diffusion assay. We used polymerase chain reaction to determine presence of erythromycin and clindamycin resistance genes, disc diffusion assays to determine resistance phenotype, and microbroth dilution to determine minimal inhibitory concentration. We detected a novel phenotype in the double-disk diffusion assay for induc… Show more

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Cited by 8 publications
(14 citation statements)
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“…One of MSSA isolates was different from other LSa/b phenotypes by channel of sensitivity between clindamycin and erythromycin disc, and it looked like a "keyhole. " In South Korea, similar novel phenotype has been described in 46 of S. agalactiae isolates [5].…”
Section: Discussionsupporting
confidence: 70%
See 1 more Smart Citation
“…One of MSSA isolates was different from other LSa/b phenotypes by channel of sensitivity between clindamycin and erythromycin disc, and it looked like a "keyhole. " In South Korea, similar novel phenotype has been described in 46 of S. agalactiae isolates [5].…”
Section: Discussionsupporting
confidence: 70%
“…S. pneumoniae bacteria can cause serious invasive infections, such as meningitis, bacteremia, and pneumonia, as well as non-invasive infections such as sinusitis and acute middle ear infections [4]. S. agalactiae causes serious infections in newborns and pregnant women, acute and chronic respiratory infections, endocarditis, sepsis, meningitis, and pyelonephritis [5,6]. S. pyogenes causes uncomplicated upper respiratory tract and skin infections, but also severe life-threatening infections, which are very common in developing countries [7].…”
Section: Introductionmentioning
confidence: 99%
“…agalactiae was due to erm (B) or lnu (B) variants (Srinivasan et al . ). Nevertheless, susceptibility to clindamycin either alone or in combination with erythromycin observed among L, I and KH phenotypic isolates indicated their response to erythromycin treatment.…”
Section: Discussionmentioning
confidence: 97%
“…Depending on the regulatory region and expression of erm genes, resistance phenotypes can be either constitutive (cMLS B ) or inducible (iMLS B ) (Srinivasan et al . ). With an increased rate of mutations in erm genes and evolution of unknown resistance mechanisms, novel phenotypes have been detected among the clinical pathogen such as Streptococcus agalactiae , illustrating an increasing complexity of resistance to MLS antibiotics (Srinivasan et al .…”
Section: Introductionmentioning
confidence: 97%
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