Identification of a Novel Uncultured Rickettsia Species Strain (Rickettsia Species Strain Tselenti) in Cyprus

Sandalakis, Vassilios; Chochlakis, Dimosthenis; Ioannou, Ioannis; Psaroulaki, Anna

doi:10.4269/ajtmh.11-0508

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…Further recent analysis of this rickettsial DNA revealed a match with a newly described Rickettsia species strain Tselentii in Cyprus [13]. A further patient was diagnosed, by a four-fold increase in antibodies, as a R. felis infection (unpublished data).…”

Section: Resultsmentioning

confidence: 99%

Skin Lesions and Inoculation Eschars at the Tick Bite Site in Spotted Fever Group Rickettsioses: Experience from a Patient Series in Eastern Crete, Greece

et al. 2014

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The main clinical signs and symptoms caused by a rickettsial infection typically begin 6-10 days after the bite and are accompanied by nonspecific findings such as fever, headache and muscle pain. The diagnosis is mainly based on serological tests, however antibody presentation may be delayed, at least at the early stages of the disease, while seroconversion is usually detected 10-15 days after disease onset. Culture is difficult, requires optimized facilities and often proves negative. Under this scope, the presence of a characteristic inoculation eschar at the bite site may prove a useful clinical tool towards the early suspicion and diagnosis/differential diagnosis of tick-borne rickettsioses, even before the onset of rash and fever or serological confirmation. We describe herein the presence of skin lesions and/or an inoculation eschar at the tick bite site in 17 patients diagnosed, by molecular means, as suffering from spotted fever group rickettsioses. The detection of the pathogen's DNA in biopsy samples proved to be a useful means for early rickettsiae detection and identification. Moreover, the presence of an infiltrated erythema always seemed to precede the appearance of an eschar by 2-5 days and the initiation of fever by 1-10 days; these two signs might also prove useful in the context of the final diagnosis.

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Section: Resultsmentioning

confidence: 99%

Skin Lesions and Inoculation Eschars at the Tick Bite Site in Spotted Fever Group Rickettsioses: Experience from a Patient Series in Eastern Crete, Greece

et al. 2014

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“…(Rhipicephalus) turanicus , a species previously reported as infected with R. aeschlimannii in Spain [ 114 ]. More human infections with R. conorii, R. aeschlimannii, R. sibirica mongolotimonae, as well as a new Rickettsia species (originally described in Cyprus by Sandalakis et al [ 115 ]) were diagnosed in patients in Crete [ 32 ], with three ticks (two Rh. turanicus and one Hy.…”

Section: Tick-transmitted Bacteria and Diseases And Associated Tick Speciesmentioning

confidence: 99%

Tick-Borne Pathogens and Diseases in Greece

Efstratiou

Karanis

2021

Microorganisms

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Tick-borne diseases (TBDs) are recognized as a serious and growing public health epidemic in Europe, and are a cause of major losses in livestock production worldwide. This review is an attempt to present a summary of results from studies conducted over the last century until the end of the year 2020 regarding ticks, tick-borne pathogens, and tick-borne diseases in Greece. We provide an overview of the tick species found in Greece, as well as the most important tick-borne pathogens (viruses, bacteria, protozoa) and corresponding diseases in circulation. We also consider prevalence data, as well as geographic and climatic conditions. Knowledge of past and current situations of TBDs, as well as an awareness of (risk) factors affecting future developments will help to find approaches to integrated tick management as part of the ‘One Health Concept’; it will assist in avoiding the possibility of hotspot disease emergencies and intra- and intercontinental transmission. Increased surveillance in Greece is required to ensure clear and effective policies for TBD control.

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“…strain colombianensi Amblyomma dissimile Colombia [ 159 ] – – Rickettsia sp.- novel isolate Ixodes ricinus Czech Republic [ 160 ] – – Rickettsia sp. strain Tselenti Hyalomma anatolicum excavatum Rhipicephalus turanicus Cyprus [ 161 ] – – Rickettsia sp. strain IbR/CRC Ixodes boliviensis Costa Rica [ 162 ] – – …”

Section: New Rickettsiaementioning

confidence: 99%

Neglected aspects of tick-borne rickettsioses

et al. 2018

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Rickettsioses are among the oldest known infectious diseases. In spite of this, and of the extensive research carried out, many aspects of the biology and epidemiology of tick-borne rickettsiae are far from being completely understood. Their association with arthropod vectors, the importance of vertebrates as reservoirs, the rarity of clinical signs in animals, or the interactions of pathogenic species with rickettsial endosymbionts and with the host intracellular environment, are only some examples. Moreover, new rickettsiae are continuously being discovered. In this review, we focus on the ‘neglected’ aspects of tick-borne rickettsioses and on the gaps in knowledge, which could help to explain why these infections are still emerging and re-emerging threats worldwide.

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Identification of a Novel Uncultured Rickettsia Species Strain (Rickettsia Species Strain Tselenti) in Cyprus

Cited by 3 publications

References 23 publications

Skin Lesions and Inoculation Eschars at the Tick Bite Site in Spotted Fever Group Rickettsioses: Experience from a Patient Series in Eastern Crete, Greece

Skin Lesions and Inoculation Eschars at the Tick Bite Site in Spotted Fever Group Rickettsioses: Experience from a Patient Series in Eastern Crete, Greece

Tick-Borne Pathogens and Diseases in Greece

Neglected aspects of tick-borne rickettsioses

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